Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Principal Consultant - Senior SAP Account Manager
$150K - $180K *
Unlock potential by managing and expanding relationships with large enterprise clients. Drive strategic account growth and new business development in the SAP ecosystem, ensuring client satisfaction a...
3 weeks ago
Professional Services Manager (HEDIS & Risk)
$95K - $115K *
Lead the charge in managing client engagements within healthcare, translating complex data and workflows into actionable solutions. Drive customer success by fostering relationships and guiding client...
Yesterday
$69K - $107K *
Champion client success by leveraging technical expertise to enhance platform value, optimize workflows, and drive measurable outcomes. Collaborate with cross-functional teams to deliver innovative so...
4 weeks ago
Writer, Marketing and Communications
$89K - $105K *
Deliver compelling marketing and policy content that enhances brand voice and reputation. Collaborate with teams to translate complex topics into clear narratives, ensuring high-quality, timely materi...
1 week ago
Director, 211 Manufacturing Quality and Regulatory Affairs
$190K - $228K *
Drive enterprise Quality and Regulatory governance for U.S. operations, ensuring compliance with FDA regulations and overseeing manufacturing quality in the therapeutic radiopharmaceutical sector whil...
Reposted 2 weeks ago
$80K - $95K *
Drive plant-level sales strategies and cultivate customer relationships to enhance beverage production. Collaborate with teams to identify opportunities and deliver solutions, ensuring consistent prod...
3 weeks ago
Senior Director Product Management
$172K - $287K *
Join us to shape the future of pharmacy by leading product strategy and innovation. Drive growth and commercialization for a diverse portfolio of healthcare technology solutions, influencing enterpris...
Reposted 1 week ago
National Accounts Director; Payor Accounts
$220K - $255K *
Shape the future of healthcare by leading strategic payor relationships and driving reimbursement strategies. Collaborate cross-functionally to enhance patient access and optimize coverage for innovat...
3 weeks ago
APP - Certified Nurse Midwife | Women's Health OBGYN
$95K - $115K *
Shape the future of women's health by providing comprehensive midwifery care across inpatient and outpatient settings. Collaborate with a multidisciplinary team to support mothers and newborns through...
Today
$80K - $95K *
Lead and advance the Operations Quality Assurance program, establishing standards and leveraging analytics and AI to drive performance improvements across teams while fostering talent development and...
1 week ago
Sr. Staff Engineer (Fullstack/Frontend)
$150K - $180K *
Lead the charge in architectural innovation and technical strategy across systems. Shape long-term solutions, drive frontend performance, and foster cross-functional collaboration to enhance user expe...
Reposted 4 weeks ago
Quality Analyst IV - Clinical Validation Auditor (CVA), Healthcare
$85K - $110K *
Empower quality assurance by overseeing clinical audits, ensuring accuracy and consistency. Collaborate with auditors to enhance performance, mentor teams, and drive process improvements in a remote e...
2 weeks ago
Manager, Clinical Stewardship Operations (RN)
$150K - $165K *
Build and manage clinical stewardship operations, driving client success through effective program implementation and cross-functional collaboration. Leverage clinical expertise to enhance client rela...
3 days ago
Global Account Executive - Life Sciences | Luma
$150K - $180K *
Unlock potential by driving digital transformation in Life Sciences. Engage with CxOs and R&D teams to deliver innovative SaaS solutions, navigate complex sales cycles, and build lasting partnerships...
2 weeks ago
$135K - $160K *
Lead the charge in offensive security research, tackling software supply chain vulnerabilities and zero-day threats. Collaborate with teams to innovate security capabilities and publish impactful find...
2 days ago
$110K - $130K *
Join a team that's shaping federal policy and advocacy. As a Government Affairs Manager, you'll engage with Congress and the Executive Branch, driving strategic initiatives across key domestic issues...
1 week ago
Sr. Manager, Enterprise Customer Success - Select
$125K - $169K *
Transform customer outcomes by leading a high-performing team dedicated to leveraging Samsara's solutions. Drive strategic growth while ensuring enterprise clients realize sustained value from their i...
Reposted 1 week ago
$110K - $130K *
Engage your expertise to lead complex HL7 integrations across healthcare systems, enhancing interoperability and data-sharing capabilities. Collaborate with stakeholders to ensure successful implement...
4 weeks ago
Director of Data Governance (Remote Work Option)
$165K - $175K *
Drive the strategic execution of an enterprise data governance program, shaping policies and fostering collaboration among stakeholders to enhance data quality and compliance across the organization...
2 weeks ago
Staff Application & Product Security Engineer
$160K - $180K *
Unlock potential by leading application security initiatives, enhancing product security, and driving secure development practices. Collaborate with engineering teams to establish standards, manage vu...
3 weeks ago
$110K - $130K *
Join us in shaping the future of maternal and newborn health by leading innovative strategies in commodity financing and procurement. Drive impactful change at global and country levels to ensure esse...
1 week ago
Therapy Development Specialist - Northeast Region
$110K - $175K *
Accelerate patient care by optimizing therapy pathways and engaging key stakeholders. Collaborate with healthcare teams to enhance VTE awareness and program development, driving clinical initiatives a...
1 week ago
Senior Oncology Account Manager, Jacksonville
$150K - $230K *
Transform the oncology landscape by driving product success and building strong relationships with healthcare professionals. Leverage your expertise to enhance patient access and deliver innovative so...
1 week ago
Lead Advisor, Commissioning & Assurance
$131K - $196K *
Architect and lead the commissioning process for cutting-edge liquid-cooled and AI factory deployments. Ensure rigorous testing and validation, providing independent assurance on performance and desig...
4 weeks ago
Implementation Consultant, Audit
$100K - $120K *
Build customer relationships by delivering seamless onboarding and maximizing platform adoption, driving value realization through proactive guidance and cross-team collaboration...
Reposted yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.