Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Gastroenterologist Jobs in South Dakota

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$72K - $90K *

Join a team that's dedicated to delivering high-quality MRI examinations, utilizing advanced imaging techniques while ensuring patient comfort and safety. Collaborate in a professional environment foc...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Unlock potential by managing and optimizing project-level agreements, ensuring compliance and efficiency in contracting processes while supporting global operations and client needs in a dynamic legal...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$128K - $192K *

The Workday Financials Integrations Senior Principal Consultant - Global AMS is a seasoned professional responsible for leading integration efforts and managing Workday financial services for clients...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Champion the clinical supply chain for late-stage oncology trials, ensuring seamless operations and communication between sites, suppliers, and stakeholders. Drive continuous improvement and complianc...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $176K *

Elevate medical information operations by managing inquiries, developing responses, and ensuring compliance. Collaborate with healthcare professionals to deliver high-quality communication and support...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join us to oversee pharmacy services, ensuring quality care through effective planning, execution, and evaluation. Collaborate with healthcare teams to enhance patient outcomes while supervising staff...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$125K *

Engage with clients by leveraging data analysis and technical expertise to drive revenue growth. Collaborate with sales teams to ensure data accuracy and create tailored solutions, enhancing customer...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$100K - $120K *

Elevate operational efficiency by managing account priorities and delivering proactive business solutions. Collaborate with teams to ensure high-quality service and maintain strong relationships with...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$94K - $151K *

Join a team that's shaping the future of insurance products by leading strategic initiatives, ensuring compliance, and driving market analysis. Collaborate with product managers to define vision and e...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by designing and optimizing enterprise data solutions in a Databricks Lakehouse environment, supporting critical missions with a focus on scalability and best practices...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$139K - $220K *

Empower revenue teams by developing impactful sales enablement programs, tailored for Public Sector customers, enhancing their skills and tools to effectively deliver GitLab solutions across various g...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Advance client relationships and team performance as a strategic leader, overseeing captive insurance operations, driving excellence, and enhancing service delivery while managing complex engagements...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$160K - $200K *

Drive enterprise sales by creating pipeline, closing complex contracts, and building strategic relationships. Collaborate with leadership to scale revenue and develop a repeatable sales motion in the...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$69K - $125K *

Transform regulatory insights into actionable strategies by analyzing national and state legislative activities. Collaborate with legal and business teams to ensure compliance and support effective de...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead compliance efforts in marketing by ensuring all materials meet legal standards. Collaborate with cross-functional teams to apply guidelines effectively while maintaining a keen attention to detai...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Advance clinical documentation accuracy by collaborating with healthcare teams to ensure comprehensive patient records, reflecting severity of illness and risk of mortality, while maintaining complian...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $195K *

Engage in strategic account acquisition for our Legal Technologies sector, focusing on sourcing, qualifying, and closing new enterprise accounts. Drive revenue growth through complex sales cycles whil...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Legal & Accounting

$156K - $212K *

Shape the future of training by leading impactful learning solutions for obesity and related conditions. Collaborate with cross-functional teams to design and deliver engaging curricula that enhance f...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$160K - $190K *

Engage with a dynamic team to represent technical positions in standards communities, author specifications, and build credibility through implementation. This role offers growth opportunities, aiming...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Information Technology

$300K *

Oversee wound management practices, providing expert care in post-acute settings. Enjoy a flexible schedule with no nights or weekends, while delivering modern treatment to patients across multiple fa...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$105K - $120K *

Tackle the challenges of IT modernization by providing remote and on-site support for the Air National Guard's infrastructure, ensuring seamless deployment and maintenance across numerous installation...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$214K - $308K *

Empower security excellence by leading high-performing teams, driving strategic initiatives, and collaborating across functions. Own major security programs and represent the organization to executive...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$162K - $195K *

Lead the launch of a novel cardiac myosin inhibitor in your territory, driving sales and building strategic relationships with healthcare providers. Collaborate with internal teams to meet patient nee...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$118K - $144K *

Unlock your potential by driving marketing performance through data analysis, reporting, and strategic insights. Collaborate with cross-functional teams to enhance decision-making and optimize growth...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$85K - $95K *

Unlock potential by leading business analysis to transform processes into actionable requirements for a major financial management system. Collaborate with stakeholders to enhance workflows and ensure...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.