Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Senior Implementation Project Manager
$110K - $130K *
Manage implementation projects, ensuring clear ownership and accountability across complex customer engagements while maintaining rigorous oversight of critical paths and deliverables for timely launc...
Reposted 4 weeks ago
$100K - $120K *
Unlock potential by delivering comprehensive health assessments in patients' homes. This role requires extensive travel within a region, ensuring quality care and education while collaborating with he...
2 weeks ago
$100K - $120K *
Drive comprehensive health assessments by traveling to patients' homes, ensuring accurate documentation and patient education. Collaborate with healthcare teams to enhance care continuity while managi...
2 weeks ago
Senior AI & Cyber Defense Specialist
$120K - $145K *
Join a team that's redefining cybersecurity by leveraging AI to enhance defense strategies. Engage with customers across the Americas, translating complex concepts into actionable insights while drivi...
Yesterday
Senior Program Manager, Maternal Health
$100K - $120K *
Unlock potential by leading innovative strategies for AI-enabled maternal care. Drive program implementation, manage complex projects, and engage stakeholders to enhance health outcomes in low- and mi...
Today
Senior Manager, Commercial Training (Rare Disease)
$134K - $219K *
Join a team that's dedicated to enhancing commercial training for rare diseases. Lead innovative learning experiences, collaborate with cross-functional teams, and drive impactful training programs th...
1 week ago
Director, Client Strategy and Growth
$185K - $210K *
Engage with clients to drive retention and growth strategies, fostering deep relationships and collaboration across teams. Leverage market insights to enhance product offerings and ensure client succe...
3 weeks ago
Territory Manager | Eastern WA & Montana
$90K - $180K *
Drive market expansion and adoption of innovative medical devices by developing strategic relationships and sales initiatives to increase market share within healthcare systems, focusing on cardiologi...
Reposted 6 days ago
$150K - $180K *
Transform the future of revenue accounting by leading the integration of consumer revenue streams into a unified, automated process. Drive accuracy and efficiency while building a high-performing team...
4 weeks ago
$125K - $150K *
Grow your career by owning enterprise sales processes, building relationships, and closing deals in home décor, beauty/wellness, and online retail. Drive significant revenue growth by leveraging consu...
Reposted today
Manager, Client Strategy & Operations
$100K - $120K *
Join a team that's focused on enhancing client delivery and relationship growth. Drive data-driven strategies and cross-functional collaboration to optimize post-sale operations, ensuring exceptional...
Reposted 2 weeks ago
Senior Manager, Regulatory Affairs
$120K - $145K *
Transform regulatory strategies for rare disease and cardio-pulmonary drug-device programs. Collaborate with cross-functional teams to ensure compliance and drive successful submissions globally, supp...
2 weeks ago
Sr. Program Manager - Implementation
$115K - $140K *
Engage as an experienced implementation leader managing complex client onboarding and execution of digital banking solutions. Collaborate across teams to drive project success, enhance operational eff...
4 weeks ago
$80K - $95K *
Transform energy solutions by leading diverse projects, conducting analyses, and collaborating with clients. Utilize engineering expertise to drive efficiency and sustainability in various sectors, en...
3 weeks ago
$79K - $127K *
Drive your career forward by overseeing tax compliance and accounting functions. You'll conduct research, manage filings, and identify opportunities while ensuring adherence to evolving tax laws. Join...
3 weeks ago
Director of Engineering, Cyber GRC Data, AI & Automation
$160K - $210K *
Lead the charge in transforming Cyber Governance, Risk & Compliance through innovative data, AI, and automation strategies. Drive measurable outcomes and modernize technology platforms while building...
Yesterday
$100K - $125K *
Accelerate progress at our financial reporting function by leading compliance, ensuring accurate statements, and mentoring a skilled team. Drive technical accounting excellence and support executive d...
1 week ago
Senior Employee Relations Partner
$110K - $135K *
Collaborate with leaders to manage employee relations and complex investigations, providing expert guidance and risk assessments in a dynamic, regulated environment. Drive best practices and support w...
1 week ago
Director, PB Coding Operations & Education
$122K - $177K *
Lead coding operations and education initiatives to ensure compliance, accuracy, and optimal reimbursement across the organization. Manage staff training and oversee coding standards while collaborati...
1 week ago
Remote Telehealth Registered Dietitian | FT W2
$65K - $105K *
Contribute to transformative care for underserved women by analyzing assessments, providing counseling, and collaborating with healthcare professionals in a fully remote setting. Your expertise will e...
1 week ago
Sr. Architect, Professional Services (Alteryx Experience Preferred)
$121K - $132K *
Lead the charge in architecting and implementing scalable analytics solutions for enterprise customers, while collaborating with cross-functional teams to ensure successful platform adoption and opera...
4 weeks ago
$112K - $140K *
Transform your career by leading claims advocacy efforts, managing complex coverage issues, and providing expert guidance to brokers and clients. Collaborate with teams to ensure positive outcomes and...
3 weeks ago
$164K - $305K *
Lead the charge in developing strategic relationships with C-suite executives to drive growth, retention, and value realization across complex health systems, ensuring integrated solutions and measura...
1 week ago
Certified Registered Nurse Anesthetist | Rapid City Hospital
$160K - $190K *
Shape the future of anesthetic care by collaborating with a dedicated team to provide safe, patient-focused services. Your expertise will drive quality outcomes in a supportive environment that champi...
Reposted today
Executive Director, Total Rewards
$168K - $240K *
Lead total rewards strategy for a complex global healthcare tech firm. Drive compensation and benefits governance, align workforce investment with business goals, and ensure compliance while fostering...
Reposted 4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.