Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Project Lead, Client Onboarding (Remote)
$88K - $105K *
Manage the end-to-end onboarding of healthcare clients, leading cross-functional teams to ensure smooth transitions into coding and billing services while driving operational improvements and maintain...
1 week ago
Mid-Market Account Executive - MOLAT
$80K - $95K *
Drive new business growth by owning the full sales cycle in the mid-market segment. Leverage your expertise in cybersecurity solutions to maximize revenue and collaborate cross-functionally to achieve...
Reposted 1 week ago
Bioanalytical Technical Proposal Manager
$100K - $120K *
Shape the future of technical proposals by collaborating with cross-functional teams to create compelling, scientifically accurate documents that meet client needs and drive business success in the li...
1 week ago
Senior Network Development Contractor
$100K - $120K *
Drive network expansion by engaging providers and negotiating contracts to enhance Medicare services. Collaborate with a remote team to ensure network adequacy and build strong relationships with heal...
2 weeks ago
Director, Engineering (AI Patient Engagement Platform)
$180K - $230K *
Join a dynamic team as you lead engineering efforts to develop an AI Patient Engagement Agent, transforming clinical trials by automating patient interactions and enhancing operational efficiency for...
2 weeks ago
$160K - $180K *
Join a team that's driving growth in Life Sciences by managing key client relationships and delivering innovative solutions. You'll oversee the entire sales process, collaborating with experts to achi...
4 weeks ago
Executive Director, Account Management
$255K - $310K *
Lead a high-performing team to execute market access strategies, optimize payer engagement, and enhance product positioning. Drive collaboration across stakeholders to ensure effective reimbursement a...
1 week ago
Sr. Manager, Strategy - Oncology & Multispecialty
$120K - $145K *
Join a dynamic strategy team to analyze oncology and specialty care initiatives, building models and providing insights that guide leadership decisions across various commercial segments...
Reposted 1 month ago
$100K - $130K *
Elevate your career by leading innovative geochemical projects in mining. Collaborate with multidisciplinary teams to deliver impactful solutions, mentor emerging professionals, and drive business dev...
3 weeks ago
Senior Group Manager, Customer Success
$134K - $184K *
Shape the future of customer success by leading a high-performing team, optimizing operations, and driving engagement and retention strategies to achieve key performance indicators and enhance client...
2 weeks ago
Senior Principal, Business Management
$135K - $160K *
Drive strategic initiatives by developing KPI frameworks and operational dashboards, analyzing performance data, and collaborating across teams to enhance business outcomes and support informed decisi...
Today
$130K - $200K *
Lead the charge in driving sales performance through strategic account management, collaboration, and innovative program execution within the C&S hospital sector, while fostering relationships and del...
1 week ago
Regional Sales Director - Oklahoma City
$180K - $215K *
Elevate regional sales performance by leading a high-impact team, executing strategic launches, and fostering key customer relationships in a dynamic, fast-paced environment. Drive accountability and...
1 week ago
Associate Director, US Pricing, Contracting and Channel Strategy
$157K - $256K *
Shape strategic pricing and channel strategies for innovative therapies, ensuring patient access and affordability. Lead cross-functional initiatives, optimize distribution models, and drive market in...
3 days ago
$85K - $110K *
Develop engaging, platform-native content that connects healthcare insights with audiences. Collaborate with teams to create innovative social media strategies, transforming complex information into r...
Reposted 1 week ago
Producst Sales Specialist-General Imaging - St. Louis
$90K - $110K *
Champion sales growth by developing strategic relationships and driving GI Ultrasound product sales. Leverage market insights to enhance customer engagement and achieve revenue targets while maintaini...
6 days ago
$150K - $180K *
Champion a transformative product vision, leading cross-functional teams to drive strategic outcomes in a dynamic digital health environment. Shape the future of patient care and client experience whi...
1 week ago
Senior Oncology Account Manager, Kansas City
$150K - $230K *
Grow your career with a dynamic team focused on oncology solutions, driving product promotion and building relationships with key stakeholders to enhance patient access and care in a competitive bioph...
1 week ago
$110K - $130K *
Join a team that's dedicated to enhancing enterprise IAM governance. You'll oversee access reviews, ensure compliance, and collaborate with cross-functional teams to strengthen security controls and d...
Yesterday
Staff Security Governance Engineer, Policies & Standards
$168K - $238K *
Optimize security governance and policy management by leveraging automation and AI. Collaborate with cross-functional teams to ensure compliance with emerging regulations and enhance policy effectiven...
Reposted 3 weeks ago
Senior Sales Engineer, Data Products
$125K - $160K *
Join a team that's redefining data solutions by leading technical sales efforts, collaborating with Account Managers, and driving customer success through innovative data architecture and tailored dem...
3 days ago
Director, Consumer Digital Product Operations
$168K - $231K *
Drive transformation by partnering with cross-functional teams to design and implement effective product operations, ensuring alignment with strategic goals and enhancing organizational effectiveness...
1 week ago
Drinking Water Treatment Practice Leader
$120K - $200K *
Lead national strategy and innovation in drinking water treatment, driving technical excellence and growth across multiple states. Collaborate with teams to enhance capabilities and deliver impactful...
4 weeks ago
$95K - $115K *
Contribute to impactful SaaS implementations, guiding clients through setup, data migration, and training while leading complex projects to success across municipal government sectors...
1 month ago
$110K - $130K *
Elevate your career by designing and automating GRC systems that enhance compliance visibility and efficiency. Collaborate with cross-functional teams to implement AI-powered solutions, ensuring strea...
Reposted yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.