Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Gastroenterologist Jobs in South Dakota

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$126K - $173K *

Develop and enhance a data-driven decisioning platform, collaborating with cross-functional teams to optimize personalized member experiences while balancing immediate needs with long-term strategic g...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$164K - $246K *

Unlock potential by driving customer transformation and success in strategic accounts. Leverage your leadership skills to enhance value across deployments, ensuring satisfaction and optimizing the ado...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$85K - $90K *

Elevate community engagement by building trusted relationships with senior living staff and residents. Act as a vital connector, ensuring seamless access to on-site care services while fostering colla...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$191K - $305K *

Champion innovative healthcare solutions by leveraging clinical expertise to enhance value-based strategies, drive operational excellence, and foster strategic partnerships for improved member care an...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$229K - $458K *

Champion strategic growth initiatives in advanced manufacturing, driving business development and forging key partnerships. Collaborate with cross-functional teams to enhance service offerings and mee...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a team that's transforming software sales by driving technical solutions and creative outreach. Lead the full sales cycle and collaborate cross-functionally to deliver unique insights and busines...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $187K *

Innovate the future of AI security by designing and implementing robust defenses against adversarial threats, ensuring the integrity of AI systems while fostering innovation and collaboration across c...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$275K - $325K *

Drive the growth of healthcare practices by owning strategy, partnerships, and P&L. Collaborate with teams to deliver tailored financial solutions, while leveraging your network to establish Flex as t...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Shape strategic growth by identifying and pursuing federal contracting opportunities. Leverage industry relationships and market insights to drive business development initiatives and enhance corporat...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$78K - $128K *

Lead the product lifecycle for health plans, driving strategy, development, and market alignment. Collaborate with cross-functional teams to enhance offerings and ensure compliance, while identifying...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$175K - $185K *

Elevate executive and client experiences by designing luxury hospitality programs across a national portfolio, ensuring exceptional service standards and memorable interactions in corporate environmen...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Business Services

$119K - $186K *

Transform the future of supply chain technology by leading innovation initiatives, managing a structured evaluation process, and engaging stakeholders to drive measurable value and strategic alignment...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$104K - $143K *

Shape the future of enterprise data capabilities by leading product strategy and agile teams to enhance personalized decision-making across channels. Collaborate with stakeholders to translate busines...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join a team that's redefining healthcare recruiting by building and scaling a high-impact Direct Employer business through innovative sales strategies and cutting-edge technology, driving growth direc...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Staffing

$150K - $200K *

Lead the charge in optimizing clinical documentation processes, enhancing provider education, and fostering collaboration with service line leaders to improve documentation integrity and reduce admini...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$120K *

Transform mental health care by building strategic partnerships with providers to enhance access to specialized OCD treatment. Drive growth through relationship-building, education, and effective refe...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Empower your career by leading and scaling a multidisciplinary engineering team in full-stack and data engineering. Drive impact through collaboration and technical excellence, ensuring quality and in...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$223K - $317K *

Drive the evolution of a robust Fulfillment platform, shaping architecture and strategy while mentoring teams. Lead modernization efforts to enhance scalability, reliability, and performance, ensuring...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$200K - $225K *

Transform marketing strategies to drive growth and engagement across public and private sectors. Lead integrated marketing efforts, brand positioning, and customer marketing services while leveraging...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Education, Government & Non-Profit

$162K - $292K *

Join a team that's redefining identity operations by leading a 24/7 team to enhance access management strategies. You'll shape the vision, drive process innovation, and foster talent in a collaborativ...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $100K *

Take ownership of complex desktop and mobile device support, ensuring high customer satisfaction. Administer enterprise management platforms and collaborate with teams to deliver effective technology...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $100K *

Transform endpoint management by leading complex support initiatives, ensuring seamless service delivery across diverse environments. Collaborate with teams to enhance user experience and optimize tec...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$250K - $280K *

Shape the future of our enterprise sales segment by driving growth and account success. Take ownership of new logo acquisitions, deepen existing client relationships, and establish best practices for...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $230K *

Empower your career by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and enhance patient access while col...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $115K *

Elevate your career by driving growth and operations in health plan partnerships. This role combines sales enablement and partner operations, directly impacting revenue through strategic collaboration...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.