Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Director, Global People Operations & Compliance
$152K - $259K *
Shape the future of global People Operations by leading a dynamic team to innovate and streamline processes, enhancing the employee experience through technology and strategic partnerships across func...
3 weeks ago
Sr. Advisory Consultant, Data Governance
$110K - $130K *
Take ownership of data governance by facilitating alignment among stakeholders, executing metadata management, and coaching teams on sustainable stewardship practices. Drive data quality and complianc...
Reposted 3 weeks ago
Regional Sales Director - Upstate NY
$180K - $215K *
Join us to lead regional sales efforts, driving product launch success and team performance. You'll build strong customer relationships, execute strategic plans, and foster a high-performing culture i...
1 week ago
$96K - $131K *
Explore a key role in enhancing corporate audits across financial and operational processes, collaborating with leaders to ensure compliance and optimize risk management initiatives while contributing...
1 month ago
Senior Director, Global People Operations
$232K - $290K *
Shape the future of global People Operations by leading innovative HR service delivery, enhancing employee experiences, and driving operational excellence in a rapidly scaling biopharmaceutical enviro...
3 weeks ago
21GRAMS- Group Copy Supervisor
$135K - $145K *
Partner with us to elevate healthcare communications by crafting compelling copy for HCP campaigns. Lead creative initiatives, collaborate with cross-functional teams, and ensure brand consistency acr...
3 days ago
Senior Budget and Financial Analyst (Remote)
$95K - $110K *
Lead financial management and analysis efforts to support strategic planning and budget execution for DHS initiatives, ensuring alignment with mission priorities and stakeholder requirements while dri...
Yesterday
Senior Director, Order-to-Cash (O2C)
$155K - $160K *
Drive the Order-to-Cash strategy, overseeing cash application, collections, and AR performance. Collaborate cross-functionally to optimize cash flow and enhance financial reporting, ensuring timely re...
Today
$95K - $115K *
Unlock the potential of implementation science as a Senior Program Analyst, driving quality improvement and program evaluation initiatives. Manage processes, databases, and reporting to enhance projec...
1 week ago
$160K - $200K *
Join a team that's dedicated to establishing a robust Quality Management System, ensuring compliance and excellence in global clinical development and commercialization. Lead quality initiatives and f...
3 weeks ago
$150K - $180K *
Accelerate growth by leading global partnerships with PwC and GSIs. Drive revenue through strategic relationship management, co-selling initiatives, and market expansion while collaborating with cross...
3 days ago
Technical Program Manager (TPM)
$115K - $145K *
Engineer innovative systems and processes to enhance product delivery, ensuring cross-functional teams operate efficiently and effectively. Drive execution, manage stakeholder alignment, and facilitat...
2 weeks ago
Associate Director, Field Reimbursement
$211K - $235K *
Drive patient access initiatives by leveraging oncology expertise to navigate reimbursement landscapes, educate stakeholders, and resolve complex access issues, ensuring timely therapy access for pati...
3 days ago
Principal Enterprise Architect
$160K - $190K *
Join a team that's driving architectural excellence and AI adoption. You'll optimize cloud systems, enhance data processing, and lead engineering teams to innovate and scale efficiently, ensuring robu...
3 weeks ago
Director, Supply Chain Operations
$125K - $150K *
Join a dynamic team to optimize supply chain operations, ensuring efficient medication delivery from pharmacy partners to patients. Oversee systems, processes, and a team to scale operations amidst ra...
Reposted 1 week ago
Senior Oncology Account Manager, Denver
$150K - $230K *
Drive impactful oncology solutions by building strong relationships with key stakeholders, promoting innovative products, and exceeding performance goals in a dynamic biopharma environment. Your exper...
1 week ago
$177K - $243K *
Advance your career by leading a global compensation function, shaping strategies, and building a high-performing team. Collaborate with key stakeholders to drive compensation programs that align with...
4 weeks ago
Senior Medical Science Liaison, Southeast (Multiple Territories)
$190K - $220K *
Engage with key stakeholders to drive prelaunch and launch strategies, translating clinical data into actionable insights. Build trusted relationships and ensure readiness for successful product adopt...
1 week ago
Senior Manager, Patient Services Promotions
$138K - $183K *
Lead the development and execution of patient support strategies to enhance access and engagement for oncology therapies, collaborating cross-functionally to optimize promotional initiatives and drive...
1 week ago
Sr. / Principal Medical Writer (Regulatory focus) - Sponsor-dedicated; NA/CAN/UK
$110K - $130K *
Advance your career by leading medical writing projects in a regulatory environment. Collaborate with cross-functional teams to produce high-quality documents, ensuring compliance with industry standa...
6 days ago
Sr. / Principal Medical Writer (Regulatory focus) - Sponsor-dedicated; NA/CAN/UK
$80K - $175K *
Champion the creation of high-quality regulatory documents, managing writing tasks and leading reviews. Collaborate across teams to ensure clarity and compliance, mentoring junior writers while delive...
Reposted 2 weeks ago
$80K - $95K *
Empower clients by managing energy procurement operations, leading RFP processes, and delivering market insights. Collaborate with suppliers and customers to optimize strategies in deregulated electri...
2 weeks ago
$120K - $150K *
Champion demand generation by executing integrated campaigns to drive pipeline growth and revenue, collaborating cross-functionally with Sales and Product teams for fuel growth through strategic marke...
Reposted 4 weeks ago
21GRAMS- Director, Product Design
$140K - $155K *
Empower teams to elevate product design through strategic vision, fostering collaboration across disciplines to create impactful digital experiences that meet user needs and business goals while ensur...
6 days ago
Director, Enterprise Portfolio Enablement
$110K - $130K *
Drive your career with a strategic role focused on enhancing project management standards and integrating enterprise initiatives. Collaborate with leaders to improve clarity, prioritization, and execu...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.