Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Gastroenterologist Jobs in South Dakota

Sort By: Relevance

$180K - $215K *

Join us to lead regional sales efforts, driving product launch success and team performance. You'll build strong customer relationships, execute strategic plans, and foster a high-performing culture i...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$96K - $131K *

Explore a key role in enhancing corporate audits across financial and operational processes, collaborating with leaders to ensure compliance and optimize risk management initiatives while contributing...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$232K - $290K *

Shape the future of global People Operations by leading innovative HR service delivery, enhancing employee experiences, and driving operational excellence in a rapidly scaling biopharmaceutical enviro...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$135K - $145K *

Partner with us to elevate healthcare communications by crafting compelling copy for HCP campaigns. Lead creative initiatives, collaborate with cross-functional teams, and ensure brand consistency acr...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $110K *

Lead financial management and analysis efforts to support strategic planning and budget execution for DHS initiatives, ensuring alignment with mission priorities and stakeholder requirements while dri...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$155K - $160K *

Drive the Order-to-Cash strategy, overseeing cash application, collections, and AR performance. Collaborate cross-functionally to optimize cash flow and enhance financial reporting, ensuring timely re...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Unlock the potential of implementation science as a Senior Program Analyst, driving quality improvement and program evaluation initiatives. Manage processes, databases, and reporting to enhance projec...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $200K *

Join a team that's dedicated to establishing a robust Quality Management System, ensuring compliance and excellence in global clinical development and commercialization. Lead quality initiatives and f...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Accelerate growth by leading global partnerships with PwC and GSIs. Drive revenue through strategic relationship management, co-selling initiatives, and market expansion while collaborating with cross...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$115K - $145K *

Engineer innovative systems and processes to enhance product delivery, ensuring cross-functional teams operate efficiently and effectively. Drive execution, manage stakeholder alignment, and facilitat...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$211K - $235K *

Drive patient access initiatives by leveraging oncology expertise to navigate reimbursement landscapes, educate stakeholders, and resolve complex access issues, ensuring timely therapy access for pati...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $190K *

Join a team that's driving architectural excellence and AI adoption. You'll optimize cloud systems, enhance data processing, and lead engineering teams to innovate and scale efficiently, ensuring robu...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$125K - $150K *

Join a dynamic team to optimize supply chain operations, ensuring efficient medication delivery from pharmacy partners to patients. Oversee systems, processes, and a team to scale operations amidst ra...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $230K *

Drive impactful oncology solutions by building strong relationships with key stakeholders, promoting innovative products, and exceeding performance goals in a dynamic biopharma environment. Your exper...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$177K - $243K *

Advance your career by leading a global compensation function, shaping strategies, and building a high-performing team. Collaborate with key stakeholders to drive compensation programs that align with...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$190K - $220K *

Engage with key stakeholders to drive prelaunch and launch strategies, translating clinical data into actionable insights. Build trusted relationships and ensure readiness for successful product adopt...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$138K - $183K *

Lead the development and execution of patient support strategies to enhance access and engagement for oncology therapies, collaborating cross-functionally to optimize promotional initiatives and drive...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Advance your career by leading medical writing projects in a regulatory environment. Collaborate with cross-functional teams to produce high-quality documents, ensuring compliance with industry standa...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $175K *

Champion the creation of high-quality regulatory documents, managing writing tasks and leading reviews. Collaborate across teams to ensure clarity and compliance, mentoring junior writers while delive...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Empower clients by managing energy procurement operations, leading RFP processes, and delivering market insights. Collaborate with suppliers and customers to optimize strategies in deregulated electri...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$120K - $150K *

Champion demand generation by executing integrated campaigns to drive pipeline growth and revenue, collaborating cross-functionally with Sales and Product teams for fuel growth through strategic marke...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $155K *

Empower teams to elevate product design through strategic vision, fostering collaboration across disciplines to create impactful digital experiences that meet user needs and business goals while ensur...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive your career with a strategic role focused on enhancing project management standards and integrating enterprise initiatives. Collaborate with leaders to improve clarity, prioritization, and execu...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$85K - $100K *

Join a team that's dedicated to providing comprehensive medical care by assessing, diagnosing, and treating patients while promoting health education and collaboration with physicians to enhance patie...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$112K - $140K *

Unlock potential by bridging finance and IT as you optimize Oracle Fusion Cloud. Drive process improvements, manage updates, and enhance data flows while ensuring seamless operations and stakeholder e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.