Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Gastroenterologist Jobs in South Dakota

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$65K - $108K *

Unlock potential by providing advanced technical support and engineering expertise to resolve complex production issues. Manage end-to-end case ownership while collaborating with teams to enhance serv...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$89K - $136K *

Innovate clinical application support to enhance patient care efficiency. Manage software upgrades, coordinate with IT teams, and lead projects while ensuring compliance and effective communication ac...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$134K - $179K *

Lead the charge in bridging genomic variants with clinical insights, collaborating with scientists to automate and scale curation workflows. Drive innovation in AI/ML applications while ensuring softw...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Elevate your career by leading strategic product marketing initiatives, managing high-impact projects, and collaborating cross-functionally to drive value propositions in enterprise technology, includ...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$186K - $234K *

Grow your career by driving sales and building relationships in the neurology and rare disease sectors. Collaborate with healthcare professionals to enhance patient care and achieve sales targets whil...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$92K - $120K *

Join a dynamic team as a Medical Claims Auditor, ensuring compliance and integrity in healthcare payments. Collaborate with cross-functional teams to identify fraud, waste, and abuse while leveraging...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Drive growth by promoting innovative regenerative medicine solutions. Leverage your expertise in vascular surgery sales and establish strong customer relationships to achieve targets and make a meanin...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$148K - $248K *

Shape the future of software sales by leading a dynamic team in the Southeastern US. Drive revenue growth, enhance customer relationships, and foster a high-performing culture while leveraging GitLab...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$210K - $260K *

Transform the workplace culture and integration of two organizations, ensuring support for clinicians and staff while enhancing benefits, compensation, and recruitment strategies to foster a unified m...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$73K - $115K *

Help us drive operational excellence in provider data management, ensuring accuracy and efficiency throughout the lifecycle. Collaborate with teams to enhance processes, leverage insights, and impleme...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$140K - $228K *

Lead the charge in enhancing cybersecurity by driving detection engineering, incident response, and automation. Collaborate cross-functionally to secure cloud architectures and improve operational eff...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$175K - $205K *

Transform client relationships and drive growth by leading strategic initiatives in scientific visualization, medical education, and digital engagement. Manage multidisciplinary teams and oversee acco...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $155K *

Join a team that's redefining energy solutions by designing innovative fluid and power systems. As a Process Engineer, you'll drive the development and optimization of cutting-edge technologies in a f...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$135K - $165K *

Pioneer operational excellence in Design leadership, managing workflows, prioritizing projects, and developing talent. Collaborate cross-functionally to enhance Design integration in AI-driven product...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $135K *

Support the growth of health plan accounts by fostering client relationships, analyzing data, and driving retention in a fast-paced, independent role. Leverage strong communication and analytical skil...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$100K - $125K *

Transform healthcare analytics by leading the development of APR-DRG audit criteria. Collaborate with cross-functional teams to enhance payment integrity through data-driven insights and innovative so...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$80K - $95K *

Champion excellence in rehabilitation services by leading a dedicated team, ensuring compliance with regulations, and enhancing patient care while achieving financial goals and fostering collaboration...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Innovate data-driven strategies to enhance business decision-making and optimize reporting processes. Leverage expertise in BI, CRM Analytics, and Salesforce to deliver actionable insights and support...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$180K - $215K *

Lead the charge in regional sales execution, driving product launch success and team performance through strategic planning, customer engagement, and cross-functional collaboration in a dynamic enviro...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead efforts to enhance patient access and exceed performance goals while navigating a co...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$200K - $236K *

Lead the charge in developing strategic partnerships for Oura's innovative in-ring payment solutions. Drive commercial agreements, build cross-functional alignment, and shape a roadmap for expanding p...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Consumer Technology

$130K - $133K *

Advance clinical research by leading site monitoring and management efforts. Ensure compliance with regulatory standards while overseeing study protocols and data integrity. Collaborate with teams to...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Join a dynamic Legal team to provide actionable regulatory advice across pharmacy laws, impacting healthcare and e-commerce. Collaborate with diverse business units to navigate complex legal landscape...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$268K - $466K *

Champion early clinical development in a dynamic team. Lead clinical research physician role for first-in-human studies, ensuring compliance and collaboration across scientific and regulatory areas to...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Champion your career by driving oncology product success and building impactful relationships with healthcare professionals. Leverage your expertise to enhance patient access and deliver innovative so...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.