Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Gastroenterologist Jobs in South Dakota

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$170K - $180K *

Unlock potential by leading a diverse team of technical professionals to ensure timely project delivery and operational excellence. Drive collaboration, manage risks, and enhance project management pr...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Information Technology

$145K - $152K *

Champion program excellence by leading complex federal initiatives, managing multidisciplinary teams, and fostering strong stakeholder relationships to ensure successful delivery and client satisfacti...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$150K - $230K *

Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure patient access while embodyi...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$109K - $164K *

Drive advanced digital forensics and incident response initiatives while mentoring a skilled engineering team. Leverage deep technical knowledge to enhance operational capabilities and ensure exceptio...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$122K *

Champion project success by leading interdisciplinary teams to deliver innovative solutions in the biotech and pharma sectors. Drive milestone achievement, manage budgets, and ensure compliance with p...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$246K - $339K *

Champion the evolution of our Data Platform by architecting scalable solutions for large-scale data migrations, empowering teams with self-service storage capabilities, and ensuring reliability across...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Consumer Technology

$200K - $245K *

Empower the oncology portfolio strategy by driving regional marketing initiatives, fostering KOL relationships, and executing launch tactics to optimize product adoption and customer engagement across...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$126K - $173K *

Transform member experiences by leading a dynamic marketing pod, driving execution and collaboration across teams to deliver personalized journeys efficiently and effectively, while maximizing platfor...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $230K *

Drive impactful oncology product promotion by building strong relationships with key stakeholders, exceeding performance goals, and ensuring patient access to innovative therapies within your territor...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $230K *

Pioneer innovative oncology solutions by building strong relationships with key stakeholders, driving product adoption, and exceeding performance goals in a dynamic biopharma environment focused on pa...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$131K - $240K *

Shape the future of training and development in orthopedic medical devices, enhancing sales effectiveness and fostering strong partnerships across teams. Drive learning initiatives and support surgica...

RemoteRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $85K *

Grow your career with a dynamic team focused on client success, managing relationships, and delivering tailored solutions. Drive satisfaction and retention while collaborating across departments to en...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$119K - $134K *

Partner with us to enhance patient care by supporting primary care teams remotely. Collaborate with on-site providers to manage patient needs effectively, ensuring seamless communication and coordinat...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$80K - $100K *

Join a team that's driving growth by acquiring new customers and enhancing revenue through innovative solutions. Manage the full sales cycle while collaborating with cross-functional teams to ensure e...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Unlock potential by leading pre-sales technical strategies that align solutions with client needs, driving revenue growth and retention through collaboration with sales teams and delivering tailored p...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$75K - $105K *

Empower healthcare delivery by ensuring coding accuracy as you analyze medical records, identify improvement opportunities, and enhance AI diagnostic models to uphold high-quality standards in inpatie...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Join a team that shapes global regulatory strategy in a fast-paced environment. You will lead comprehensive regulatory plans, ensuring alignment and execution from development to post-marketing, impac...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in optimizing drug library implementations for smart infusion pumps, collaborating with healthcare teams to enhance medication safety and workflow efficiency across mid- to large-sized...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$140K - $180K *

Shape the future of clinical quality assurance by overseeing trials, ensuring compliance with GCP and ICH standards, and driving operational excellence across clinical activities within a cross-functi...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$218K - $350K *

Shape the future of healthcare by leading our subscription business, driving growth and innovation. Collaborate across teams to enhance customer experience and optimize performance, ensuring alignment...

RemoteRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$113K - $188K *

Empower healthcare systems by leading advisory projects, managing teams, and delivering data-driven solutions. Collaborate with clients to enhance performance and build strong relationships while ensu...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$80K - $120K *

Grow your career with a dynamic sales role, driving supply chain transparency for leading brands. Own the full sales cycle, engage senior stakeholders, and develop solutions that enhance customer valu...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$174K - $374K *

Engage with patients in their homes to conduct health evaluations, build relationships, and bridge care gaps. This role demands extensive travel and flexibility to provide personalized care and diagno...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$184K - $230K *

Lead the charge in transforming business readiness and deployment excellence across the Americas, ensuring seamless Oracle E-Business Suite upgrades while aligning regional priorities with global stra...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K *

Deliver exceptional medical sales solutions by building relationships with healthcare professionals, demonstrating products, and exceeding sales goals while ensuring customer satisfaction and effectiv...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.