Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$170K - $180K *
Unlock potential by leading a diverse team of technical professionals to ensure timely project delivery and operational excellence. Drive collaboration, manage risks, and enhance project management pr...
2 days ago
$145K - $152K *
Champion program excellence by leading complex federal initiatives, managing multidisciplinary teams, and fostering strong stakeholder relationships to ensure successful delivery and client satisfacti...
2 weeks ago
Senior Oncology Account Manager, San Francisco
$150K - $230K *
Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure patient access while embodyi...
1 week ago
$109K - $164K *
Drive advanced digital forensics and incident response initiatives while mentoring a skilled engineering team. Leverage deep technical knowledge to enhance operational capabilities and ensure exceptio...
Reposted 2 weeks ago
Senior Project Manager, Analgesia
$122K *
Champion project success by leading interdisciplinary teams to deliver innovative solutions in the biotech and pharma sectors. Drive milestone achievement, manage budgets, and ensure compliance with p...
Reposted today
Principal Engineer, Data Platform
$246K - $339K *
Champion the evolution of our Data Platform by architecting scalable solutions for large-scale data migrations, empowering teams with self-service storage capabilities, and ensuring reliability across...
Today
Senior Regional Marketer -- West Region
$200K - $245K *
Empower the oncology portfolio strategy by driving regional marketing initiatives, fostering KOL relationships, and executing launch tactics to optimize product adoption and customer engagement across...
1 week ago
Lead, Conditions Management Marketing
$126K - $173K *
Transform member experiences by leading a dynamic marketing pod, driving execution and collaboration across teams to deliver personalized journeys efficiently and effectively, while maximizing platfor...
2 days ago
Senior Oncology Account Manager, Columbus
$150K - $230K *
Drive impactful oncology product promotion by building strong relationships with key stakeholders, exceeding performance goals, and ensuring patient access to innovative therapies within your territor...
1 week ago
Senior Oncology Account Manager, Dallas West
$150K - $230K *
Pioneer innovative oncology solutions by building strong relationships with key stakeholders, driving product adoption, and exceeding performance goals in a dynamic biopharma environment focused on pa...
Reposted 1 week ago
National Field Development Specialist - Foot and Ankle & Trauma
$131K - $240K *
Shape the future of training and development in orthopedic medical devices, enhancing sales effectiveness and fostering strong partnerships across teams. Drive learning initiatives and support surgica...
Reposted 3 days ago
Account Manager- Client Success
$80K - $85K *
Grow your career with a dynamic team focused on client success, managing relationships, and delivering tailored solutions. Drive satisfaction and retention while collaborating across departments to en...
1 week ago
APP (NP/PA) Primary Care Inbox Management (remote)
$119K - $134K *
Partner with us to enhance patient care by supporting primary care teams remotely. Collaborate with on-site providers to manage patient needs effectively, ensuring seamless communication and coordinat...
1 week ago
Account Executive, HME Provider Sales
$80K - $100K *
Join a team that's driving growth by acquiring new customers and enhancing revenue through innovative solutions. Manage the full sales cycle while collaborating with cross-functional teams to ensure e...
3 days ago
$120K - $145K *
Unlock potential by leading pre-sales technical strategies that align solutions with client needs, driving revenue growth and retention through collaboration with sales teams and delivering tailored p...
Yesterday
$75K - $105K *
Empower healthcare delivery by ensuring coding accuracy as you analyze medical records, identify improvement opportunities, and enhance AI diagnostic models to uphold high-quality standards in inpatie...
Reposted 3 weeks ago
Senior Regulatory Affairs Consultant - Regulatory Project Manager
$120K - $145K *
Join a team that shapes global regulatory strategy in a fast-paced environment. You will lead comprehensive regulatory plans, ensuring alignment and execution from development to post-marketing, impac...
Reposted 2 days ago
$110K - $130K *
Lead the charge in optimizing drug library implementations for smart infusion pumps, collaborating with healthcare teams to enhance medication safety and workflow efficiency across mid- to large-sized...
1 week ago
Senior Manager, Clinical Quality Assurance (Remote)
$140K - $180K *
Shape the future of clinical quality assurance by overseeing trials, ensuring compliance with GCP and ICH standards, and driving operational excellence across clinical activities within a cross-functi...
Reposted 4 days ago
Conditions Subscriptions Director
$218K - $350K *
Shape the future of healthcare by leading our subscription business, driving growth and innovation. Collaborate across teams to enhance customer experience and optimize performance, ensuring alignment...
3 weeks ago
$113K - $188K *
Empower healthcare systems by leading advisory projects, managing teams, and delivering data-driven solutions. Collaborate with clients to enhance performance and build strong relationships while ensu...
Yesterday
$80K - $120K *
Grow your career with a dynamic sales role, driving supply chain transparency for leading brands. Own the full sales cycle, engage senior stakeholders, and develop solutions that enhance customer valu...
1 week ago
In-Home Traveler Physician Full Time - DC
$174K - $374K *
Engage with patients in their homes to conduct health evaluations, build relationships, and bridge care gaps. This role demands extensive travel and flexibility to provide personalized care and diagno...
1 month ago
Director, Delivery & Deployment Excellence
$184K - $230K *
Lead the charge in transforming business readiness and deployment excellence across the Americas, ensuring seamless Oracle E-Business Suite upgrades while aligning regional priorities with global stra...
3 days ago
Account Executive, Patient Monitoring (Midwest)
$90K *
Deliver exceptional medical sales solutions by building relationships with healthcare professionals, demonstrating products, and exceeding sales goals while ensuring customer satisfaction and effectiv...
Reposted 2 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.