Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Manager, Quality Assurance (LTSS)
$104K - $143K *
Join a dynamic team to lead Quality Assurance efforts in Long-Term Services and Supports. Oversee compliance, collaborate with external partners, and drive operational excellence while ensuring adhere...
1 week ago
Quality of Care and Clinical Review Nurse
$69K - $125K *
Join a dynamic team to oversee quality of care investigations and improvement initiatives, ensuring compliance with regulatory standards while enhancing patient outcomes and organizational efficiency...
1 week ago
$90K - $110K *
Transform healthcare delivery by leading clinical operations, ensuring high-quality patient care, and fostering collaboration across departments. Drive strategic initiatives while managing resources a...
3 weeks ago
Principal IT Analyst - Veeva RIM
$121K - $161K *
Transform your career by leading the design and implementation of Veeva Vault RIM, ensuring optimal performance and compliance while collaborating with cross-functional teams to enhance user experienc...
3 weeks ago
Director, Partnerships and Business Development - Southeast
$150K - $180K *
Transform your career by driving strategic partnerships in healthcare. Leverage your extensive relationships within benefits consulting to influence and expand business opportunities while collaborati...
Reposted 4 weeks ago
Software Architect (AWS/Azure)
$101K - $135K *
Join a team that's shaping the future of healthcare technology by designing and enhancing our build and delivery infrastructure. Collaborate with architects and developers to implement best practices...
1 week ago
Associate Director, Medical Affairs- Hematology (northern CA/Nevada)
$176K - $287K *
Lead the charge in advancing scientific discourse by engaging KOLs and HCPs in Hematological Malignancies. Drive strategic medical initiatives while fostering relationships to enhance research and cli...
4 weeks ago
Medical Specialist I - North Dakota & South Dakota
$140K - $190K *
Lead the charge in driving sales growth within the Pulmonary therapeutic area by building strong relationships with healthcare professionals and implementing strategic initiatives to enhance product u...
3 days ago
$135K - $145K *
Drive innovative software solutions by developing robust, cloud-native systems that enhance provider data management capabilities and meet the evolving needs of clients in a dynamic, collaborative env...
Reposted 2 days ago
Senior Oncology Account Manager, Tampa
$150K - $230K *
Engage key stakeholders in oncology by promoting innovative products, building relationships, and driving access to care. Lead strategic initiatives to exceed performance goals while embodying corpora...
1 week ago
Chief of Staff - Vice President of HIV, Hepatitis, and TB
$110K - $130K *
Join a dynamic team to drive strategic initiatives and enhance global health outcomes. Collaborate with senior leadership to synthesize complex data, manage special projects, and prepare impactful com...
Reposted 1 week ago
Director, Information Security
$120K - $145K *
Champion the advancement of enterprise information security by leading strategy, managing risks, and ensuring compliance. Collaborate with executives to enhance security posture while supporting innov...
1 week ago
Senior Oncology Account Manager, Chicago South
$150K - $230K *
Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Collaborate with healthcare professionals to enhance patient access and exceed performanc...
1 week ago
$140K - $190K *
Shape the future of healthcare revenue cycle performance by leading transformative initiatives, optimizing client success, and fostering innovation across multiple healthcare partnerships. Drive measu...
3 weeks ago
Associate Director, Quality Assurance - Technical
$150K - $195K *
Empower quality assurance excellence by leading GMP oversight for contract manufacturing and validation projects, ensuring compliance and collaboration across technical operations to support drug deve...
2 weeks ago
Senior Oncology Account Manager, Phoenix East
$150K - $230K *
Optimize your career by driving oncology product success and building impactful relationships with healthcare professionals. Leverage your expertise to enhance patient access and deliver innovative so...
1 week ago
Medical Writer, Medical Communications
$80K - $110K *
Transform clinical data into engaging scientific content with growth opportunities. Collaborate, communicate, and adhere to guidelines in a dynamic environment, supporting varied projects across forma...
Reposted 2 weeks ago
$128K - $178K *
Lead the charge in shaping the future of destination marketing through data-driven insights and innovative product strategies. Collaborate with cross-functional teams to enhance customer experiences a...
3 weeks ago
Account Director, Promotional Medical Education
$100K - $120K *
Partner with us to drive strategic healthcare marketing initiatives. Lead client relationships, oversee peer-to-peer programs, and mentor team members to ensure compliance and achieve results while fo...
Reposted 2 weeks ago
Senior Oncology Account Manager, Pittsburgh
$150K - $230K *
Empower oncology practices by driving product adoption and building relationships with key stakeholders. Lead strategic initiatives to enhance patient access and optimize territory management while ex...
1 week ago
$86K - $118K *
Lead the charge in managing complex healthcare projects, ensuring timely delivery and budget adherence while coordinating cross-functional teams and mitigating risks for strategic initiatives...
3 days ago
$100K - $120K *
Partner with us to drive revenue growth and strategic account management across a diverse portfolio. You'll own the full sales cycle, collaborate with cross-functional teams, and build lasting relatio...
3 weeks ago
Managing Director, Construction Disputes & Advisory
$160K - $200K *
Unlock potential by leading high-performing teams in construction disputes and advisory. Drive client relationships, innovate solutions, and ensure quality execution while fostering growth and collabo...
3 weeks ago
$150K - $200K *
Elevate your career by leading HCP engagement and clinical marketing initiatives. Drive strategic insights and educational content for the HSCT portfolio, fostering impactful connections and enhancing...
2 days ago
Senior Oncology Account Manager, Saint Louis
$150K - $230K *
Help us drive oncology product success by building relationships with key stakeholders, promoting innovative therapies, and ensuring patient access while exceeding performance goals in a dynamic bioph...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.