Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Gastroenterologist Jobs in South Dakota

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$144K - $210K *

Drive compliance excellence by leading a team focused on identifying and addressing control gaps and violations across financial services, ensuring adherence to regulatory standards while enhancing su...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Finance & Insurance

$81K - $110K *

Lead the transformation of patient care by enhancing utilization review processes, ensuring quality documentation, and collaborating with healthcare teams to optimize clinical outcomes and financial p...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$160K - $190K *

Lead the charge in driving growth by managing a high-performing sales team, collaborating across functions, and executing strategic initiatives to enhance commercial success in the Hematology sector...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$155K - $175K *

Empower healthcare professionals by delivering scientific insights and fostering relationships. Drive prelaunch and launch strategies in a dynamic environment, ensuring clinical readiness and impactfu...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $105K *

Optimize healthcare support by serving as the primary contact for clinical application issues. Collaborate with clinicians and IT teams to troubleshoot, educate, and resolve technical challenges, ensu...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Staffing

$100K - $120K *

Elevate project outcomes by leading cross-functional teams to deliver clinical research projects on time and within budget, ensuring compliance with regulatory standards and client expectations while...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$228K - $342K *

Empower your career by leading strategic project management initiatives across early drug development. Drive process optimization, cultivate high-performing teams, and collaborate with executives to a...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$245K - $265K *

Build impactful partnerships with Medical Experts to enhance neurology care. Drive strategic insights and collaboration across teams, influencing marketing and education initiatives while engaging wit...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Unlock potential by owning the end-to-end product surface, driving discovery, design, and migration while collaborating closely with users to solve real market problems in a dynamic healthcare environ...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$192K - $235K *

Lead analytical development and quality control for sterile parenteral products, ensuring regulatory compliance and successful product launches. Collaborate cross-functionally to establish strategies...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$98K - $163K *

Support audit remediation initiatives by coordinating with stakeholders, analyzing findings, and developing strategies to enhance audit readiness and internal controls, ensuring effective communicatio...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$217K - $271K *

Launch your career by owning the national Field Excellence model, managing operations for a groundbreaking oncology therapy. Collaborate with sales leaders to enhance prescriber access and streamline...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$147K - $274K *

Develop advanced document understanding systems to enhance legal content processing. Collaborate across teams to design, deploy, and evaluate models that drive measurable impact in legal, tax, and acc...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Media

$80K - $95K *

Join a team that's dedicated to enhancing healthcare quality through thorough medical claims audits. Leverage your nursing expertise in a dynamic remote environment, collaborating with experienced aud...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$285K - $325K *

Drive transformational patient impact by leading cross-functional teams and executing strategic drug development programs in an agile environment. Foster collaboration and accountability to deliver in...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$252K - $315K *

Champion psychiatric practice excellence by developing standards and frameworks, enhancing clinician support, and driving quality improvement initiatives to elevate patient outcomes and operational ef...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in managing informatics projects from planning to delivery, ensuring timely decision-making and risk management. Collaborate with cross-functional teams to enhance health information e...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Business Services

$79K - $127K *

Innovate with us to enhance data protection strategies, ensuring robust security and compliance across diverse platforms. Collaborate on complex projects, troubleshoot incidents, and drive improvement...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $125K *

Drive impactful fundraising efforts by managing a diverse portfolio of major donors. Collaborate with leadership and teams to enhance donor engagement and achieve ambitious financial goals across the...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $105K *

Empower project success by coordinating PGHD initiatives, managing timelines, and engaging stakeholders. Drive quality and productivity through effective planning, documentation, and communication wit...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Advance your career by driving market intelligence and product strategy for RUO oncology and transplant products. Collaborate with cross-functional teams to enhance customer relationships and ensure s...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$138K - $201K *

Transform provider analytics by leading data-driven insights for contracting, performance, and network strategy. Collaborate with cross-functional teams to enhance network adequacy and drive strategic...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$116K *

Lead site activation efforts by coordinating with cross-functional teams to ensure timely and quality delivery of clinical projects. Drive strategic initiatives and mitigate risks while enhancing comm...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$200K - $235K *

Drive product excellence by owning the lifecycle and security of high-performance client SaaS platforms hosted on AWS. Lead a dedicated team to optimize operations, ensure compliance, and deliver seam...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $150K *

Drive growth and strategy for key telehealth categories by leveraging market insights, customer feedback, and cross-functional collaboration to enhance performance and deliver exceptional customer exp...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.