Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$95K - $160K *
Elevate your career by supporting senior leaders in a dynamic tech environment. Manage complex calendars, coordinate travel, and streamline processes to enhance productivity and drive success across g...
Yesterday
Principal Consultant - SAP Analytics Solution Lead/Architect
$135K - $160K *
Lead the SAP Analytics strategy and implementation, driving innovation in analytics solutions. Collaborate with stakeholders to deliver insights and manage teams, ensuring successful deployment of SAP...
3 weeks ago
CMC Program Lead TLX597 & TLX66
$135K - $160K *
Lead the charge in developing and executing CMC strategies for antibody-based radiopharmaceuticals, ensuring alignment with Stage-Gate requirements while managing cross-functional teams and external p...
2 days ago
$150K - $175K *
Lead the charge in transforming financial operations while ensuring compliance and accuracy. Collaborate with cross-functional teams to enhance processes, manage audits, and drive strategic initiative...
6 days ago
Senior Product Manager, Sales, Marketing & Business Solutions
$140K - $175K *
Join a dynamic team to drive the strategy and roadmap for Sales and Marketing platforms, focusing on Salesforce and marketing automation. Collaborate with stakeholders to prioritize initiatives and de...
2 weeks ago
Senior Manager, Data Science & Advanced Analytics
$170K - $190K *
Transform data into actionable insights by leading a team of data scientists and analysts. Drive advanced analytics initiatives, foster collaboration with stakeholders, and ensure high-quality deliver...
1 week ago
Director, Field Analytics, Hematology
$174K - $234K *
Shape the future of Hematology analytics by leading strategic insights and performance initiatives. Collaborate with cross-functional teams to enhance field execution and drive commercial success thro...
1 week ago
$130K - $150K *
Unlock potential by leading the full sales cycle in healthcare, engaging C-suite executives and driving strategic decisions. Leverage your experience to meet quotas, build account strategies, and enha...
Reposted today
Senior Oncology Account Manager, Miami
$150K - $230K *
Transform patient care by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure timely access to thera...
1 week ago
Manager, Product Management - Provider Contracting, Credentialing & Network
$108K - $180K *
Join us in leading product strategy and execution for a diverse portfolio, enhancing Provider Contracting and Credentialing. Collaborate with cross-functional teams to drive innovation, improve custom...
3 days ago
Senior Director, Fair Lending Solutions
$160K - $190K *
Join us in shaping the future of Fair Lending solutions. Drive product strategy, deliver expert analysis, and enhance client outcomes while navigating complex regulatory landscapes. Your expertise wil...
Yesterday
Senior Clinical Advisor, Age-Friendly Health Systems
$250K - $325K *
Unlock the potential of age-friendly health systems by providing strategic clinical leadership and guidance. Collaborate with health systems to implement the 4Ms framework, driving improvements in car...
2 weeks ago
Financial Improvement & Audit Remediation Specialist
$89K - $148K *
Elevate financial management and audit remediation efforts for DoD clients, leveraging expertise in accounting, internal controls, and compliance to drive strategic improvements and ensure adherence t...
1 week ago
Account Specialist (Macon, GA)
$160K - $192K *
Inspire commercial success by engaging healthcare providers and driving product adoption. Collaborate with cross-functional teams to support launches and optimize patient access, ensuring impactful re...
5 days ago
Head of AI & Business Transformation
$150K - $180K *
Transform your career by leading AI initiatives that drive business growth and operational efficiency. Collaborate across functions to embed AI into Rho's core operations, shaping a future where AI en...
1 week ago
Senior Manager - Dazodalibep HCP Launch Marketing
$149K - $202K *
Transform the HCP launch landscape by leading innovative marketing initiatives for a groundbreaking treatment in Sjögren's disease. Collaborate cross-functionally to engage healthcare professionals an...
Yesterday
$110K - $130K *
Drive healthcare transformation by leading advanced consulting initiatives, enhancing delivery systems, and improving health outcomes. Collaborate with clients and stakeholders to implement strategic...
2 weeks ago
$72K - $192K *
Join a team that's dedicated to enhancing client relationships in healthcare. As a trusted advisor, you'll guide clients through workflows, drive feature adoption, and develop strategic plans to maxim...
Yesterday
Workday Financials Senior Principal Consultant, Accounting Center - Global AMS
$128K - $192K *
The Workday Financials Senior Principal Consultant, Record to Report is a seasoned professional responsible for leading the Financials workstream and ensuring operational efficiency in Workday Financi...
Reposted 2 weeks ago
Senior Software Engineer, Interoperability
$169K - $220K *
Join a team that's dedicated to transforming healthcare through innovative software solutions. Collaborate with engineers and healthcare professionals to build systems that enhance patient care and st...
3 weeks ago
Field Application Scientist, Pathway & NGS Analysis Software, QDI
$100K - $124K *
Lead the charge in delivering impactful scientific software demonstrations and training. Collaborate with diverse teams to address customer needs and enhance bioinformatics solutions, driving innovati...
2 weeks ago
Senior Director / Executive Director, Pharmacovigilance
$263K - $325K *
Advance your career by building and leading the pharmacovigilance function from the ground up. In this pivotal role, you'll oversee drug safety operations, collaborate with cross-functional teams, and...
Reposted today
Regional Sales Director - Knoxville
$180K - $215K *
Elevate regional sales performance by leading a high-performing team, executing launch strategies, and fostering customer relationships in a dynamic environment. Drive accountability and collaboration...
1 week ago
$110K - $130K *
Deliver innovative solutions by managing complex programs, ensuring seamless execution and coordination across multiple contracts while leveraging extensive IT expertise and leadership skills to drive...
Reposted 1 week ago
Field Application Specialist - Separations Technology, Virgina or Mayland
$95K - $115K *
Join us to provide expert application support for cutting-edge separation technologies. Engage with customers throughout their journey, ensuring successful implementation and adoption while collaborat...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.