Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$58K - $105K *
Unlock your potential by managing the full contracting lifecycle, supporting critical agreements for Medicare Advantage and Commercial operations, while collaborating with diverse teams to enhance com...
3 days ago
Sr. Director, Scientific Affairs
$181K - $225K *
Lead the charge in operationalizing complex clinical studies globally, collaborating with cross-functional teams to enhance proposal development and manage global lab relationships, ensuring strategic...
3 weeks ago
Sr. Director, Scientific Affairs
$181K - $225K *
Lead the charge in advancing scientific operations within a dynamic team, driving global lab relationships and supporting complex clinical studies. Collaborate across functions to ensure strategic, op...
3 weeks ago
Sr. Staff Cyber Defense Engineer
$181K - $301K *
Elevate our cyber defense capabilities by architecting advanced detection and response systems. Lead cross-functional initiatives, influence technical strategy, and enhance security measures to protec...
2 weeks ago
$183K - $220K *
Lead strategic initiatives for Integrated Delivery Networks and health systems, optimizing patient access and formulary adoption. Build executive relationships and drive clinical integration to enhanc...
1 week ago
$100K - $120K *
Support public health initiatives by managing community grant portfolios, providing technical assistance, and enhancing local coalitions' capacity to prevent youth substance use. Collaborate with stak...
Yesterday
$160K - $190K *
Elevate healthcare solutions by transforming complex data needs into scalable systems. Collaborate with cross-functional teams to design and build data pipelines and insightful dashboards that enhance...
Reposted 2 weeks ago
Senior Account Director (Medical Affairs)
$155K - $175K *
Lead the charge in client partnerships while driving strategic growth and team development. Utilize your expertise to deliver impactful insights and solutions in a fast-paced, evolving environment, en...
Reposted 2 weeks ago
$215K - $235K *
Advance drug substance development and drive clinical readiness projects by leading process chemistry initiatives, collaborating with cross-functional teams, and ensuring regulatory compliance for suc...
Reposted 3 weeks ago
$150K - $175K *
Drive financial operations and internal controls while leading a remote accounting team. Oversee month-end closes, technical accounting, and ERP transformations to enhance operational efficiency and e...
Today
Sys VP Clinical and Industry Trials
$180K - $220K *
Empower innovation in clinical trials by developing strategies, overseeing operations, and cultivating partnerships. Drive excellence in research, enhance compliance, and manage a high-performing team...
Reposted 1 week ago
Director of Strategic Partnerships
$100K - $150K *
Transform the future of business development by building strategic partnerships across key professional services. Drive growth through relationship-building and co-closing deals, while shaping a natio...
3 weeks ago
$140K - $270K *
Unlock your potential as a Research Scientist, driving AI innovations in healthcare. Collaborate with cross-functional teams to develop and implement cutting-edge machine learning models that enhance...
Reposted 2 weeks ago
Clinical Sales Training Specialist, Structural Heart
$102K - $182K *
Lead the design and delivery of innovative clinical sales training programs for Structural Heart, enhancing sales team effectiveness and product knowledge through strategic curriculum development and...
Reposted 5 days ago
$144K - $184K *
Lead the strategy execution for key global clients, driving client value, retention, and new business growth while cultivating trust-based relationships with senior leaders and maximizing account pote...
Reposted 3 weeks ago
$125K - $150K *
Lead the charge in driving scalable revenue growth through integrated demand generation and digital marketing strategies. Collaborate with cross-functional teams to optimize marketing operations and e...
Today
Associate Director/Director, Asset Acquisition
$190K - $250K *
Analyze and evaluate therapeutic opportunities to drive innovation and business development. Collaborate with interdisciplinary teams to assess scientific and commercial viability, ensuring alignment...
Yesterday
Biostatistics Director, Medical Affairs
$222K - $255K *
Lead the biostatistical strategies that support impactful medical communication efforts. Collaborate cross-functionally to provide scientific expertise, develop publication strategies, and ensure meth...
Reposted 4 weeks ago
Senior Oncology Account Manager, Dallas East
$150K - $230K *
Accelerate your career by driving oncology product success and building impactful relationships with healthcare professionals. Lead strategic initiatives to enhance patient access and deliver innovati...
1 week ago
$80K - $110K *
Analyze and support value-based care initiatives, developing innovative forecasting solutions and methodologies. Collaborate across teams to translate complex data into actionable insights that guide...
Reposted 3 days ago
Director, Analytics Engineering
$139K - $285K *
Drive the analytics engineering team to create AI-ready data solutions, ensuring trusted access to data across the organization. Lead strategic initiatives, build self-service capabilities, and foster...
2 weeks ago
Medical Science Liaison, Southeast (Multiple Territories)
$155K - $175K *
Develop trusted relationships with key stakeholders, delivering scientific insights and supporting prelaunch activities. Operate independently in a dynamic environment, influencing adoption through cr...
2 weeks ago
Scientist, Analytical Development
$95K - $115K *
Join a team that's driving analytical excellence in biologics development. Lead method development and validation while ensuring compliance with cGMP standards. Collaborate across functions to support...
Today
Director, Global Regulatory Project and Submission Management
$176K - $236K *
Lead the charge in global regulatory project management, driving oncology strategies and submissions across regions. Collaborate with cross-functional teams to ensure compliance and timely market acce...
Today
Senior Director, Oncology Pharmacology
$232K - $348K *
Lead the charge in oncology pharmacology, managing scientific teams to drive drug discovery from early stages through regulatory approval while ensuring alignment across cross-functional teams...
Reposted 1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.