Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$235K - $250K *
Transform financial strategy and compliance in a dynamic fintech environment. Lead financial operations, banking relationships, and compliance initiatives to drive growth and manage risk effectively w...
1 week ago
Remote Evening Radiologist - IC
$250K - $300K *
Oversee and deliver exceptional diagnostic imaging services remotely, focusing on evening shifts. Collaborate within a dynamic team while managing varied inpatient and outpatient cases to support pati...
4 weeks ago
Senior Scientific Director - Publications (Oncology)
$150K - $180K *
Drive impactful scientific communication by overseeing content development across therapeutic areas, ensuring strategic alignment with client goals while managing a team and collaborating with various...
4 weeks ago
Senior Medical Science Liaisons (MSL) - Cardiovascular, Arizona
$190K - $225K *
Elevate your career by engaging with key opinion leaders and healthcare professionals. This role focuses on scientific collaboration and strategic partnerships, driving impactful medical insights with...
2 weeks ago
Hematology Therapeutic Specialist (Michigan/Ohio)
$110K - $130K *
Drive success by educating healthcare providers on ZYNLONTA® in the Michigan/Ohio territory. Leverage insights to foster relationships, achieve sales goals, and enhance patient experiences through eff...
1 week ago
$72K - $120K *
Transform healthcare systems by analyzing data, leading client engagements, and implementing performance improvements. Collaborate with a skilled team to deliver actionable insights and drive meaningf...
Today
Director - Product Management, LATAM
$163K - $297K *
Join a dynamic team to shape the future of digital consumer experiences in LATAM. Lead product strategy and execution for innovative e-commerce solutions, driving customer satisfaction and loyalty whi...
6 days ago
$110K - $130K *
Shape the future of client success by leading implementations and driving adoption for enterprise accounts. Collaborate across teams to ensure measurable value and build scalable processes that enhanc...
4 weeks ago
Clinical Documentation Manager
$73K - $115K *
Unlock the potential of clinical documentation integrity by driving ICD-10-CM coding accuracy and enhancing provider education. Collaborate with cross-functional teams to support risk adjustment initi...
1 week ago
Director, Client Coding Integration
$97K - $145K *
Join a dynamic team to lead physician coding integration initiatives, ensuring operational readiness and compliance. Collaborate across departments to enhance coding practices and drive revenue cycle...
Yesterday
Director, Client Coding Integration
$120K - $145K *
Execute accurate coding practices to ensure compliance and optimal reimbursement in a dynamic healthcare environment. Collaborate with clinical teams to maintain integrity and efficiency in revenue cy...
Reposted 1 week ago
Senior Manager, Clinical Conduct
$90K - $110K *
Empower cross-functional teams to drive the Future of Medicine initiatives, ensuring scalable processes and compliance while enhancing patient safety and experience through strategic planning and exec...
1 week ago
Manager, Commercial Accounting
$134K - $145K *
Optimize commercial accounting processes by managing revenue, inventory, and accounts receivable. Collaborate with cross-functional teams to ensure accurate financial reporting and drive process impro...
4 weeks ago
Senior Consultant - HHS Collaboratives
$90K - $150K *
Join a dynamic team to leverage clinical expertise in healthcare consulting, driving improvements in perinatal care and women's health. Collaborate with leaders to analyze data, share best practices...
Today
Onsite Patient Monitoring Project Manager - Georgia/Alabama
$90K - $110K *
Elevate patient care by leading project management for healthcare solutions. Drive implementation, ensure customer satisfaction, and coordinate resources while managing multiple projects in a dynamic...
6 days ago
$133K - $173K *
Shape the future of AI governance by designing frameworks and policies that ensure responsible innovation and effective risk management across the enterprise. Collaborate with cross-functional teams t...
6 days ago
$150K - $180K *
Shape and execute a comprehensive partnership strategy to drive growth, enhance market presence, and foster high-value alliances across the healthcare ecosystem, collaborating with executive leadershi...
Today
Payer Engagement Lead - Regional Accounts
$214K - $234K *
Champion strategic payer engagement across regional markets, building relationships that enhance patient access to therapies. Connect national strategies with local execution for optimal outcomes in c...
Reposted 3 weeks ago
Principal Health Data Scientist
$130K - $155K *
Lead advanced analytics and statistical modeling to transform complex healthcare data into actionable insights, collaborating with cross-functional teams to solve strategic business challenges and enh...
Today
Head of Emerging & Digital Therapeutics
$190K - $236K *
Develop and implement innovative therapeutic approaches to enhance mental health outcomes. Collaborate across departments to evaluate, integrate, and govern emerging treatments, ensuring clinical feas...
3 weeks ago
$152K - $190K *
Champion innovation by leading the design and development of LIMS applications. Collaborate with stakeholders to create reliable software solutions while guiding a team of engineers in a dynamic clini...
Today
Cardiovascular Account Specialist - U.S. Sales, Pasadena, CA
$162K - $195K *
Deliver impactful sales strategies and cultivate strategic partnerships to launch a groundbreaking cardiac treatment in your territory, effectively addressing unmet patient needs while collaborating w...
1 month ago
Associate Director - Clinical Operations - Healthcare
$155K - $259K *
Transform healthcare performance by leading integrated optimization programs that enhance clinical, operational, and financial outcomes for hospitals and health systems. Drive measurable results throu...
3 days ago
Regulatory Submissions Lead II
$110K - $130K *
Lead and execute regulatory strategies for multi-region clinical trials, ensuring compliance and timely submissions. Collaborate with project teams to manage risks and drive operational excellence thr...
4 days ago
$193K - $241K *
Lead and oversee Medical Information teams, ensuring high-quality service delivery and compliance. Drive strategic initiatives, manage resources, and collaborate cross-functionally to enhance operatio...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.