Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Head of Consumer and Lending Compliance
$150K - $215K *
Lead the charge in developing a cutting-edge compliance program for consumer financial products. You'll oversee a team, drive strategy, and ensure adherence to regulations in a fast-paced, innovative...
Reposted 1 week ago
$113K - $188K *
Unlock potential by leading product strategy and management for diverse lines, ensuring customer needs drive innovation while aligning with corporate goals. Collaborate with cross-functional teams to...
Today
Principal Software Architect - Emerging Technologies
$175K - $222K *
Engage in architecting high-volume autonomous agent pipelines, ensuring safety, performance, and compliance. Own the generator-verifier architecture and CI/CD processes while setting engineering stand...
Today
$132K - $153K *
Join a team that's redefining care management by leading strategic initiatives in utilization and appeals processes. Drive high-quality, cost-effective care while ensuring compliance and fostering a c...
1 week ago
$110K - $130K *
Lead the charge in driving sales strategy for the CT product line across the Ohio Valley. Cultivate relationships, maximize revenue, and collaborate with cross-functional teams to enhance market share...
6 days ago
Director, Global Real-World Evidence & Health Outcomes Scientist, Oncology
$204K - $340K *
Lead the charge in generating impactful real-world evidence to support oncology products, ensuring alignment with market needs and regulatory requirements while collaborating across teams to drive evi...
1 week ago
AVP Clinical Documentation (Orchestration Works)
$150K - $250K *
Unlock potential by leading innovative clinical documentation initiatives that enhance quality, compliance, and revenue cycle outcomes. Collaborate with cross-functional teams to redefine workflows an...
1 week ago
Director, NDD Business Development: Neurology Clinics
$162K - $224K *
Drive growth in the Neurodegenerative Disease sector by developing strategic partnerships with health systems and academic centers, leveraging existing relationships to create innovative solutions tha...
1 week ago
$100K - $120K *
Support clinical studies by assisting teams with tasks like medical monitoring and protocol management. Collaborate across functions and engage with stakeholders to ensure successful trial outcomes wh...
4 weeks ago
Associate Medical Director (Promotional Medical Education)
$100K - $125K *
Manage a team of medical writers to develop impactful scientific content, ensuring accuracy and compliance. Collaborate with clients and cross-functional teams to drive medical strategies and delivera...
Reposted 2 weeks ago
Healthcare Capture and Opportunity Management Specialist
$80K - $95K *
Drive impactful strategies by leveraging research and insights to advance government health opportunities. Collaborate with leaders to enhance competitive positioning and secure meaningful work that b...
1 week ago
Hematology Therapeutic Specialist (LA North)
$110K - $130K *
Join a team that's dedicated to advancing hematology care by educating healthcare providers and driving demand for innovative therapies. Leverage your expertise to foster relationships and ensure a po...
1 week ago
Senior Manager, In-Vitro Diagnostics/Precision Medicine Quality
$132K - $178K *
Champion quality in In-Vitro Diagnostics and Companion Diagnostics. Lead proactive strategies, ensuring compliance in clinical trials while collaborating with partners to enhance precision medicine in...
3 weeks ago
Regional Sales Director - Northwest
$180K - $215K *
Unlock regional growth by leading a high-performing sales team, executing launch strategies, and fostering key customer relationships in a dynamic, fast-paced environment. Drive performance and ensure...
1 week ago
Sr. Manager, Central Monitoring, Data Analysis
$120K - $145K *
Drive impactful data analysis and risk management for global clinical trials, interpreting complex data to identify trends and risks. Lead cross-functional teams in enhancing study quality and patient...
1 week ago
Manager, Market Access and Reimbursement - North Central
$136K - $170K *
Partner with us to enhance patient access by leading market access strategies, educating teams, and collaborating across departments to ensure effective reimbursement for our innovative medical techno...
4 weeks ago
Integration Analyst Engineer (Remote)
$115K - $125K *
Empower your career by driving the integration and migration of data for a vital financial management system. Collaborate with experts to enhance system reliability and operational efficiency in a ful...
3 weeks ago
Senior Scientific Director - Publications (Heme-Onc)
$150K - $180K *
Join us to lead the development and oversight of scientific content across therapeutic areas, ensuring strategic medical communication aligns with brand goals while managing a team and collaborating w...
4 weeks ago
$80K - $95K *
Optimize your career as a Financial Analyst, driving category P&L management, revenue forecasting, and strategic financial insights. Collaborate with cross-functional teams to enhance decision-making...
Yesterday
Support Engineer, U.S. Government Support
$95K - $160K *
Join our U.S. Government Support Engineering team to tackle complex technical challenges in secure environments. Leverage your Linux expertise and customer support skills to enhance GitLab's performan...
3 weeks ago
Auditor Clinical Validation Outpatient Specialty Clinical
$95K *
Advance your career by auditing outpatient and specialty claims, ensuring coding accuracy and compliance. Leverage your clinical and coding expertise to enhance audit processes and contribute to quali...
4 weeks ago
Field Application Specialist (Chrom/TFF) -Western Region
$90K - $116K *
Engage with customers to implement and optimize downstream processing technologies, providing technical expertise and support. Collaborate with stakeholders to enhance workflows and ensure successful...
2 weeks ago
$110K - $130K *
Reimagine medical communication by leading a team of writers to craft regulatory and scientific documents. Oversee projects, ensuring clarity and quality for diverse audiences while adhering to timeli...
Reposted 3 weeks ago
Lead Product Manager, Channels
$126K - $173K *
Shape the future of enterprise decisioning by leading cross-functional product initiatives that enhance customer experiences and drive operational readiness across multiple business channels...
2 days ago
Hemostasis Sales Specialist - East Texas Region
$99K - $136K *
Join a dynamic team as a strategic growth architect, driving revenue and market share expansion in the Hemostasis portfolio. Leverage your expertise in complex healthcare sales to influence decision-m...
2 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.