Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Gastroenterologist Jobs in South Dakota

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$84K - $99K *

Join a dynamic team to evaluate and process medication prior authorization requests, ensuring compliance with clinical guidelines and regulatory standards while facilitating timely patient access to n...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$246K - $332K *

Transform healthcare by leading national strategic account management efforts. Drive partnerships with key institutions, enhance patient care, and foster cross-functional collaboration to achieve comm...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$103K - $192K *

Shape the future of healthcare reimbursement by leading analytics for payor contracting and out-of-network strategies. Collaborate with cross-functional teams to optimize financial outcomes and drive...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in expanding into new healthcare verticals by developing and executing go-to-market strategies, managing partnerships, and driving campaign performance. Collaborate with cross-function...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$198K - $258K *

Lead the charge in defining and governing architectural strategies for a secure and scalable software ecosystem across device and digital platforms, influencing cross-functional teams and senior stake...

United StatesRemote

Reposted 6 days ago

  •   11 - 15 years exp.  •   Healthcare

$120K - $140K *

Empower provider accounts post-launch by driving growth through strategic engagement, tailored training, and effective collaboration with internal teams. Cultivate relationships across diverse healthc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$250K - $275K *

Transform the future of drug development by leading Analytical Development for small molecules and oligonucleotides. Drive scientific strategy, build a high-performing team, and ensure regulatory read...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Engage with a talented team to drive growth and innovation in pharma sales. Own the sales cycle from strategic prospecting to closing high-impact deals, while developing key relationships that enhance...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$205K - $240K *

Shape the future of oncology as a Senior Medical Science Liaison, creating impactful scientific engagement within hematology and oncology that enhances patient care. Collaborate with KOLs and cross-fu...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead the charge in developing and overseeing scientific content across multiple therapeutic areas, ensuring high-quality contributions and strategic client interactions to drive growth and innovation...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$126K - $173K *

Drive impactful measurement strategies by leading cross-functional teams to define and deliver comprehensive reporting solutions that enhance decision-making and optimize business outcomes across the...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$86K - $116K *

Champion data-driven emergency response initiatives by leading analytics, ensuring quality assurance, and collaborating with global teams to enhance decision-making and program effectiveness in infect...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$90K - $100K *

Transform project management by leading client-sponsored trials, coordinating multidisciplinary teams, and ensuring timely delivery of objectives while fostering collaboration and communication across...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$180K - $200K *

Champion commercial manufacturing excellence by leading technical operations, ensuring on-time delivery of drug products and APIs, and collaborating with regulatory teams to meet compliance and perfor...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$230K - $260K *

Oversee regional sales strategies and lead a team to drive oncology product sales. Collaborate cross-functionally to enhance market insights and ensure compliance while fostering team development and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$113K - $188K *

Shape the future of managed care by leading contract negotiations, performance monitoring, and strategic initiatives to optimize reimbursement and enhance payer relationships across healthcare service...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Business Services

$103K - $128K *

Join us to lead product strategy and development, driving innovation and performance in healthcare solutions. Collaborate cross-functionally to align business needs with customer expectations and ensu...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$101K - $146K *

Unlock potential by leading payer contract negotiations to enhance relationships, optimize revenue, and ensure compliance with regulations, all while aligning with strategic priorities of the health s...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$177K - $338K *

Help us advance women's health through innovative clinical trial strategies, where you will conduct, support, and report on global studies for cutting-edge compounds, ensuring adherence to regulatory...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $215K *

Drive regional sales success by leading launch execution, building high-performing teams, and fostering customer relationships. Collaborate cross-functionally to achieve strategic goals in a fast-pace...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Join a team that's redefining audit practices by leading the transition to an agentic operating model. Collaborate across functions to innovate audit methodologies and drive transformation for clients...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$173K - $245K *

Unlock insights through data analytics and experimentation to enhance credit risk management. Collaborate with cross-functional teams to optimize policies, monitor performance, and drive strategic gro...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $235K *

Join a team that's shaping the future of Medical Affairs by driving strategic client engagements and enhancing capabilities. This Director-level role balances client delivery and internal growth, focu...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$133K - $184K *

Join a team that's enhancing threat detection and response capabilities. As a hands-on technical leader, you'll drive security initiatives across cloud, infrastructure, and identity platforms, while m...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$176K - $243K *

Unlock potential by driving the adoption of advanced electrophysiology solutions through strategic partnerships, enhancing customer engagement, and fostering relationships with key stakeholders to ens...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.