Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$150K - $175K *
Accelerate growth through strategic demand generation and integrated marketing campaigns. Collaborate with Sales and Product teams to optimize the pipeline, drive revenue, and enhance customer engagem...
3 weeks ago
$100K - $120K *
Drive strategic oversight of enterprise-wide RAC audit activities, ensuring compliance and operational excellence. Collaborate with leadership to enhance audit processes, minimize financial risk, and...
1 week ago
Director, GLP-1 & Cardiometabolic Product Marketing
$194K - $242K *
Unlock potential by leading product marketing strategies in GLP-1 and cardiometabolic health. Collaborate with cross-functional teams to enhance buyer clarity and sales effectiveness, while coaching a...
6 days ago
$80K - $95K *
Join a team that's redefining inpatient coding operations, ensuring quality and compliance while optimizing workflows. Lead a dedicated team to enhance documentation practices and support financial he...
2 weeks ago
$90K - $110K *
Advance your career by providing essential maintenance and support for cyclotrons and analytical equipment, ensuring optimal performance in a dynamic oncology environment. Collaborate on quality contr...
2 weeks ago
Global Value and Access Senior Manager - Rare Disease
$120K - $150K *
Drive global access strategies for an innovative rare disease treatment, collaborating across teams to enhance payer insights and develop impactful materials. Lead initiatives that shape market entry...
Yesterday
Senior Scientist, Analytical Science & Technology
$140K - $155K *
Pioneer your career in cell therapy innovation by leading method transfers and validations. Collaborate with cross-functional teams to ensure compliance and drive quality in late-stage clinical develo...
2 weeks ago
Director, Neurology - Thought Leader Liaison (SOUTHEAST)
$245K - $265K *
Shape the future of neurology by building partnerships with Medical Experts, driving insights, and collaborating across teams to enhance patient care and strategic initiatives in a dynamic healthcare...
2 weeks ago
Wealth Advisor, Relationship Manager
$150K - $200K *
Pioneer client relationships with high-net-worth individuals, driving growth through advanced planning strategies. Collaborate in a team environment to enhance client outcomes and expand assets under...
1 week ago
Advanced Imaging Area Sales Manager – Image Guided Therapy Devices (Southwest)
$182K - $330K *
Lead the sales efforts of advanced imaging products, maximizing revenue and market presence while collaborating with clinical and sales teams to enhance performance and expand client partnerships in d...
Reposted 3 weeks ago
Account Executive, Enterprise Suite - Financial Services
$124K - $171K *
Accelerate sales growth by managing and qualifying strategic Enterprise Intelligence opportunities. Collaborate with cross-functional teams, ensuring comprehensive engagement and communication to opti...
Reposted 3 days ago
$78K - $98K *
Transform customer experiences by leading complex software implementations, ensuring seamless onboarding, testing, and launch activities. Leverage advanced product knowledge and project coordination s...
4 weeks ago
Nurse Practitioner or Physician Assistant | Hospitalist
$90K - $110K *
Lead the delivery of comprehensive medical care by assessing, diagnosing, and treating patients. Collaborate with healthcare teams to enhance patient education and ensure quality care while adhering t...
2 days ago
$150K - $200K *
Shape the future of wealth management by leading investment strategies for High Net Worth clients. Drive AUM growth, manage portfolios, and deliver tailored investment solutions while collaborating wi...
1 week ago
Clinical Application Support Specialist II- RO
$70K - $105K *
Unlock potential by providing exceptional support and training in clinical software, ensuring customer satisfaction through effective communication and problem-solving in a fast-paced environment. Joi...
2 weeks ago
$116K - $145K *
Unlock potential by leading payer negotiations and expanding access across commercial, Medicare, and Medicaid sectors. Drive strategic partnerships and ensure compliance while maximizing patient acces...
2 weeks ago
Manager of Revenue Cycle & Compliance
$120K - $135K *
Transform compliance oversight in the DME order-to-payment lifecycle. Lead audits, analyze data, and coordinate payer audits while developing practical controls and reporting to enhance revenue integr...
1 week ago
$130K - $160K *
Drive growth as an integral part of our Commercial Sales Team, managing key health system relationships and closing complex deals, while collaborating across departments and shaping the product roadma...
1 month ago
$78K - $156K *
Join a team that's dedicated to enhancing business systems through design, configuration, and support. As a Senior Application Analyst, you'll lead improvements, mentor junior analysts, and ensure sea...
2 weeks ago
$145K - $160K *
Pioneer data-driven insights by collaborating with cross-functional teams to enhance business strategies. Leverage advanced analytics and visualization skills to drive operational improvements and sup...
2 weeks ago
$85K - $100K *
Drive comprehensive audits, mentor junior staff, and ensure compliance with clinical and financial standards. Enhance revenue cycle performance by identifying issues and recommending improvements, whi...
1 month ago
Executive Director, Manufacturing
$175K - $210K *
Lead operational excellence in biopharmaceutical manufacturing, overseeing GMP processes, technology transfers, and clinical supply. Drive strategic initiatives, manage CDMO relationships, and build a...
Yesterday
$112K - $128K *
Drive business development for large-scale podcast and broadcast campaigns, fostering client relationships and achieving revenue growth. Collaborate with cross-functional teams to deliver innovative a...
2 weeks ago
$100K - $120K *
Elevate clinical research by assisting with study design, medical monitoring, and compliance to ensure effective execution of clinical trials and contribute positively to patient outcomes in alignment...
Reposted 3 weeks ago
$72K - $90K *
Lead data-driven insights to enhance business performance, collaborating across teams to support strategic initiatives. Utilize technical skills in SQL, Python, and data visualization to drive impactf...
4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.