Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Gastroenterologist Jobs in South Dakota

Sort By: Relevance

$80K - $95K *

The Data Integration Specialist at Timely will ensure seamless integration of data between school district systems and Timely's scheduling technology. This role involves collaborating with various sta...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$132K - $195K *

Transform risk management by leading assessments, negotiating treatment plans, and enhancing controls. Collaborate cross-functionally to ensure compliance and proactively address security risks while...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Unlock potential by cultivating strategic relationships with benefits consultants and brokers. Drive revenue growth through effective partnerships, collaboration with cross-functional teams, and exper...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $200K *

Lead the charge in optimizing biomarker program operations, ensuring seamless sample processing from collection to storage. Collaborate across teams to uphold quality and compliance while driving grow...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$285K - $310K *

Lead the strategic execution of global clinical trials, ensuring adherence to timelines, budgets, and quality standards while fostering collaboration across teams and mentoring Clinical Operations per...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$203K - $253K *

Strategize and lead patient advocacy and medical education initiatives, fostering collaboration with stakeholders to enhance patient engagement and inform Medical Affairs strategies. Drive impactful i...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $159K *

Inspire excellence in clinical documentation by leading a team of specialists, ensuring quality assurance, and fostering professional development. Collaborate with stakeholders to enhance operational...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $159K *

Empower the Clinical Documentation Integrity team by ensuring staff competency through quality assurance, training, and performance management. Collaborate on action plans and foster associate develop...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $159K *

Lead the charge in enhancing clinical documentation integrity by supervising staff, conducting quality reviews, and fostering professional development. Collaborate with teams to implement effective st...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$176K - $287K *

Contribute to companion diagnostic strategy and development, leading programs from biomarker feasibility to clinical validation. Collaborate across teams to ensure diagnostics align with therapeutic m...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $170K *

Champion the growth of Audit Manager by driving sales in the healthcare sector. Leverage your expertise in medical billing and coding to engage revenue cycle leaders, manage the sales pipeline, and de...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $249K *

Lead the vision and strategy for SRE across payments, driving reliability, automation, and incident management while scaling the function and fostering a culture of operational excellence and continuo...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$160K - $200K *

Drive technical excellence by designing systems, setting standards, and mentoring engineers without formal management. Collaborate with Product to ensure alignment and tackle engineering challenges ac...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$92K - $125K *

Drive operational excellence in patient access by leading teams, enhancing processes, and fostering collaboration across healthcare facilities. Your leadership will ensure compliance, improve patient...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$125K - $150K *

Unlock potential by leading Health and VA claims operations, driving strategic initiatives, enhancing recovery outcomes, and ensuring operational excellence across multiple teams and client portfolios...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$230K - $345K *

Transform clinical trial management by leading early-phase oncology programs. Drive strategic vision, operational excellence, and cross-functional collaboration to ensure timely, budget-compliant exec...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$104K - $143K *

Unlock your potential by leading strategic initiatives that drive measurable business results. Collaborate with senior leaders to solve complex problems, evaluate opportunities, and translate strategy...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $200K *

Join a dynamic team as a senior leader driving profitable growth in healthcare services. Oversee sales strategy, lead a high-performing team, and collaborate across functions to deliver innovative sol...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$285K - $385K *

Lead regulatory due diligence for clinical/commercial assets, assessing risks and strategies for licensing, acquisitions, and partnerships. Collaborate across teams to ensure regulatory integration in...

RemoteRemote

Today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Join a team that's redefining scientific data management in drug discovery. Lead the scientific data team, bridging scientists and engineers to ensure data integrity, quality, and innovative solutions...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Help us optimize Epic applications by leading projects, troubleshooting issues, and ensuring seamless integration. Collaborate with teams to enhance workflows and provide expert support, all while mai...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Join a team that's dedicated to providing exceptional anesthetic care in a Level II Trauma Center. Engage in diverse procedures and enjoy a supportive work environment with opportunities for professio...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Unlock potential by joining a dynamic anesthesia team at a Level II Trauma Center, where you'll practice diverse techniques and collaborate closely with anesthesiologists to ensure safe, effective pat...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$153K - $203K *

Drive global access and pricing strategies for hematology assets, ensuring timely reimbursement and optimal patient access. Collaborate with cross-functional teams to develop evidence-based toolkits a...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $182K *

Transform laboratory services by providing expert clinical consultation, enhancing service delivery, and fostering collaboration with healthcare professionals to meet strategic healthcare goals...

1 month ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.