Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$225K - $281K *

Lead detection and response strategy, building systems and automations to enhance security. Collaborate with teams to set standards, mentor engineers, and manage complex incidents, ensuring effective...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$133K - $191K *

Transform revenue cycle operations by leading strategic initiatives, optimizing performance, and fostering collaboration across business units to enhance service delivery and achieve organizational go...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$210K - $250K *

Empower a dynamic team of reimbursement professionals to enhance provider access and education. Drive strategic initiatives, foster collaboration, and ensure compliance while navigating complex payer...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Lead Corporate FP&A initiatives, driving budgeting, forecasting, and performance management. Oversee financial analysis and reporting while enhancing systems and dashboards for improved decision-makin...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$80K - $95K *

Transform geospatial data into impactful maps and applications, supporting intelligence operations. Collaborate with teams to analyze and visualize data, ensuring compliance with standards while enhan...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Technical Services

$110K - $130K *

Partner with us to design and implement cloud-native data solutions, ensuring secure and reliable data exchange across platforms. Collaborate with teams to enhance data accessibility and support advan...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$87K - $108K *

Empower customer success by providing expert technical support for bioprocessing products. Collaborate with teams to troubleshoot issues, enhance product knowledge, and ensure a positive experience fo...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $150K *

Shape impactful healthcare solutions by leveraging your Epic Professional Billing expertise. Collaborate with diverse teams to optimize systems, enhance workflows, and drive meaningful results for cli...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$100K - $120K *

Engage with a dynamic CRO to oversee clinical monitoring and enhance site performance. Foster relationships, ensure compliance with regulations, and lead a team in delivering quality outcomes in clini...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$74K - $124K *

Lead the charge in enhancing federal grants management operations through data analysis, stakeholder engagement, and process improvement initiatives. Collaborate with multidisciplinary teams to delive...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$185K - $327K *

Unlock potential by leading security strategy and architecture, partnering with the CISO to enhance technical oversight and incident response. Drive secure practices across teams while mentoring engin...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$73K - $110K *

Shape the future of coding quality by overseeing audits, developing guidance, and collaborating with teams to enhance accuracy and compliance in healthcare coding practices...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$147K - $274K *

Empower innovation by leading applied AI research initiatives that shape product features. Collaborate with cross-functional teams to translate complex problems into impactful AI solutions, mentoring...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Media

$110K - $130K *

Accelerate progress at an innovative healthcare firm by leading account-based marketing initiatives. Collaborate closely with Sales to create impactful marketing plays that engage targeted health syst...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$240K - $330K *

Join a team that’s pioneering growth in revenue intelligence by driving new business opportunities in financial services and healthcare. Leverage your extensive sales expertise to build relationships...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$183K - $220K *

Elevate technical storytelling by creating impactful demos and workshops that bridge the gap between product capabilities and customer understanding, empowering sales teams and enhancing buyer engagem...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Advance healthcare solutions by driving sales of innovative diagnostic instruments. Engage with key stakeholders to promote QIAstat-Dx systems, ensuring successful adoption and customer satisfaction t...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$86K - $138K *

Unlock innovative healthcare solutions by leading product strategy and lifecycle management for clinical programs. Collaborate across teams to enhance member experiences and drive business value while...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$108K - $135K *

Join our team as a Telehealth Pharmacist, where you'll enhance member health through Medication Therapy Management and clinical outreach programs, ensuring high-quality care and compliance with indust...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$250K - $290K *

Champion growth by developing best-in-class business practices, leading a high-performing new business team, managing pipeline opportunities, and fostering strategic partnerships with leadership to dr...

RemoteRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$162K - $195K *

Take ownership of driving sales performance in your territory by launching a novel cardiac myosin inhibitor. Collaborate with internal teams and external stakeholders to build strategic relationships...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$230K - $260K *

Join us to lead a regional sales team, driving strategic initiatives and fostering relationships to achieve business objectives while enhancing patient outcomes in the oncology sector...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Advance healthcare solutions by building executive relationships and driving enterprise sales. Lead the sales lifecycle, develop strategic accounts, and leverage modern tools to optimize revenue growt...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$152K - $190K *

Drive the future of data analytics by leading a dynamic team to enhance enterprise data strategies, governance, and insights that align with business objectives and foster innovation across the organi...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$83K - $108K *

Join a team that's dedicated to nurturing key accounts and driving customer success. You'll cultivate long-term relationships, collaborate across departments, and ensure optimal performance for our hi...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.