Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$80K - $100K *

Transform endpoint management by leading complex support initiatives, ensuring seamless service delivery across diverse environments. Collaborate with teams to enhance user experience and optimize tec...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$119K *

Join a dynamic team to oversee Epic applications, ensuring seamless integration and optimization across clinical services. Drive improvements in workflows and enhance patient care through effective ma...

1 week ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Accelerate progress at the forefront of rare disease management by collaborating with key stakeholders to enhance patient access and streamline treatment pathways across health systems and specialty c...

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$250K - $280K *

Shape the future of our enterprise sales segment by driving growth and account success. Take ownership of new logo acquisitions, deepen existing client relationships, and establish best practices for...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $230K *

Empower your career by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and enhance patient access while col...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $115K *

Elevate your career by driving growth and operations in health plan partnerships. This role combines sales enablement and partner operations, directly impacting revenue through strategic collaboration...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $115K *

Lead the execution and optimization of email and SMS marketing channels, enhancing performance and compliance. Own end-to-end processes, from creative testing to analytics, while collaborating cross-f...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$350K - $400K *

Optimize enterprise sales growth by leading a high-performing team, refining strategies, and driving revenue. Collaborate across departments to enhance processes and ensure long-term success in a dyna...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$114K - $186K *

Transform enterprise sales by guiding major organizations through their DevSecOps journey. Leverage your expertise to drive adoption and expansion of AI-powered solutions, ensuring long-term partnersh...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Lead strategic nursing initiatives across diverse ambulatory services, enhancing patient care, operational performance, and workforce engagement. Collaborate with executive leadership to drive quality...

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$181K - $235K *

Inspire your career with a pivotal role in HCP Marketing, driving innovative strategies and cross-functional collaboration to launch key assets. Lead brand planning and execution in a dynamic environm...

4 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Elevate clinical operations by managing staff, ensuring compliance, and enhancing patient satisfaction in a dynamic wound healing center. Drive efficiencies and oversee daily functions while fostering...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Join a dynamic team to oversee pharmacy operations, ensuring compliance and quality care in long-term settings. Utilize your expertise to conduct assessments, supervise staff, and coordinate medicatio...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $240K *

Optimize coding workflows by leveraging your 10+ years of leadership in coding, compliance, and revenue cycle management. Collaborate with AI and engineering teams to drive innovation and enhance oper...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$148K - $248K *

Unlock your leadership potential by guiding a dynamic sales team in optimizing the adoption of AI-driven DevSecOps solutions for the financial services sector, steering client relationships, and drivi...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Elevate your career by providing exceptional pre-operative and post-anesthesia care. Collaborate with a multidisciplinary team to ensure quality patient outcomes while contributing to education and re...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Drive program operations support by managing logistics, personnel processes, and documentation for a dynamic public health initiative. Collaborate with leadership to enhance efficiency and ensure comp...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$226K - $377K *

Lead the strategic management of renewals for key accounts, optimizing processes and enhancing customer relationships. Collaborate cross-functionally to drive successful outcomes while minimizing risk...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$245K - $286K *

Elevate clinical quality assurance through strategic leadership and oversight of global trials, ensuring compliance with GCP regulations. Drive quality culture and inspection readiness while mentoring...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Join a dynamic team to drive sales of innovative laboratory equipment in the Northeast. Engage with clients, deliver product demos, and exceed sales targets while fostering strong relationships and pr...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$133K - $191K *

Empower the HR technology landscape by leading strategy, governance, and optimization of HRIS. Collaborate with cross-functional teams to enhance processes, ensure data integrity, and drive digital tr...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Elevate your career by leading multiple dialysis centers, driving operational excellence, and fostering a culture of patient care. Collaborate with a dedicated team to achieve strategic growth and ens...

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$225K - $281K *

Lead detection and response strategy, building systems and automations to enhance security. Collaborate with teams to set standards, mentor engineers, and manage complex incidents, ensuring effective...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$133K - $191K *

Transform revenue cycle operations by leading strategic initiatives, optimizing performance, and fostering collaboration across business units to enhance service delivery and achieve organizational go...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$210K - $250K *

Empower a dynamic team of reimbursement professionals to enhance provider access and education. Drive strategic initiatives, foster collaboration, and ensure compliance while navigating complex payer...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.