Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$95K - $110K *

Lead financial management and analysis efforts to support strategic planning and budget execution for DHS initiatives, ensuring alignment with mission priorities and stakeholder requirements while dri...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$155K - $160K *

Drive the Order-to-Cash strategy, overseeing cash application, collections, and AR performance. Collaborate cross-functionally to optimize cash flow and enhance financial reporting, ensuring timely re...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Unlock the potential of implementation science as a Senior Program Analyst, driving quality improvement and program evaluation initiatives. Manage processes, databases, and reporting to enhance projec...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $200K *

Join a team that's dedicated to establishing a robust Quality Management System, ensuring compliance and excellence in global clinical development and commercialization. Lead quality initiatives and f...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Accelerate growth by leading global partnerships with PwC and GSIs. Drive revenue through strategic relationship management, co-selling initiatives, and market expansion while collaborating with cross...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$115K - $145K *

Engineer innovative systems and processes to enhance product delivery, ensuring cross-functional teams operate efficiently and effectively. Drive execution, manage stakeholder alignment, and facilitat...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$211K - $235K *

Drive patient access initiatives by leveraging oncology expertise to navigate reimbursement landscapes, educate stakeholders, and resolve complex access issues, ensuring timely therapy access for pati...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $190K *

Join a team that's driving architectural excellence and AI adoption. You'll optimize cloud systems, enhance data processing, and lead engineering teams to innovate and scale efficiently, ensuring robu...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$125K - $150K *

Join a dynamic team to optimize supply chain operations, ensuring efficient medication delivery from pharmacy partners to patients. Oversee systems, processes, and a team to scale operations amidst ra...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $230K *

Drive impactful oncology solutions by building strong relationships with key stakeholders, promoting innovative products, and exceeding performance goals in a dynamic biopharma environment. Your exper...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$177K - $243K *

Advance your career by leading a global compensation function, shaping strategies, and building a high-performing team. Collaborate with key stakeholders to drive compensation programs that align with...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$190K - $220K *

Engage with key stakeholders to drive prelaunch and launch strategies, translating clinical data into actionable insights. Build trusted relationships and ensure readiness for successful product adopt...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$138K - $183K *

Lead the development and execution of patient support strategies to enhance access and engagement for oncology therapies, collaborating cross-functionally to optimize promotional initiatives and drive...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Advance your career by leading medical writing projects in a regulatory environment. Collaborate with cross-functional teams to produce high-quality documents, ensuring compliance with industry standa...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $175K *

Champion the creation of high-quality regulatory documents, managing writing tasks and leading reviews. Collaborate across teams to ensure clarity and compliance, mentoring junior writers while delive...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Empower clients by managing energy procurement operations, leading RFP processes, and delivering market insights. Collaborate with suppliers and customers to optimize strategies in deregulated electri...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$120K - $150K *

Champion demand generation by executing integrated campaigns to drive pipeline growth and revenue, collaborating cross-functionally with Sales and Product teams for fuel growth through strategic marke...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $155K *

Empower teams to elevate product design through strategic vision, fostering collaboration across disciplines to create impactful digital experiences that meet user needs and business goals while ensur...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Drive your career with a strategic role focused on enhancing project management standards and integrating enterprise initiatives. Collaborate with leaders to improve clarity, prioritization, and execu...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$112K - $140K *

Unlock potential by bridging finance and IT as you optimize Oracle Fusion Cloud. Drive process improvements, manage updates, and enhance data flows while ensuring seamless operations and stakeholder e...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$142K - $177K *

Lead legal initiatives by drafting documents, managing records, and providing counsel. Collaborate with executives to shape organizational direction while ensuring compliance and supporting continuous...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$93K - $191K *

Drive strategic federal contract administration, overseeing complex engagements and advising leadership on compliance, negotiation, and performance to enhance revenue retention and operational success...

3 days ago

  •   8 - 10 years exp.  •   Business Services

$117K - $161K *

Drive your career with this strategic role, leading Workday Compensation solutions. Collaborate with cross-functional teams to optimize compensation processes, ensuring alignment with business goals a...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$140K - $170K *

Shape the future of healthcare technology by leveraging your expertise to drive sales success. Collaborate with cross-functional teams to deliver tailored solutions, engage customers, and enhance prod...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $100K *

Shape the future of medical communications by crafting high-quality, scientifically accurate content. Collaborate with diverse teams to deliver impactful resources that meet client needs while mentori...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.