Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$70K - $100K *

Drive your career as a key Sales Executive, responsible for new client acquisition and expanding our innovative staffing services in the US market. Join a dynamic team where your expertise in building...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Staffing

$140K - $190K *

Empower our sales team by driving strategic growth in key accounts. Leverage your expertise in Enterprise SaaS to navigate complex sales in the Life Sciences sector, fostering partnerships and deliver...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$78K - $113K *

Innovate healthcare fraud prevention by leading complex investigations, evaluating medical necessity, and collaborating with regulatory agencies to ensure quality member care and safeguard plan assets...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$78K - $113K *

Unlock potential by leading complex investigations into healthcare fraud, waste, and abuse. Collaborate with regulatory agencies and internal teams to ensure compliance and safeguard member care while...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$135K - $160K *

Join us to lead Oncology integrated solutions, collaborating across teams to design and implement strategic, client-focused approaches. Shape impactful proposals that drive growth and enhance patient...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$197K - $328K *

Shape the future of pharmacy network operations by leading a team of attorneys, providing strategic legal counsel on regulatory, operational, and transactional matters within the PBM landscape, while...

RemoteRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $145K *

Help us secure our cloud-based healthcare platforms by designing and implementing robust security solutions. This role demands expertise in cloud security, AI/ML protection, and compliance with indust...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$68K - $143K *

Support audit and compliance efforts for DoD financial systems, ensuring adherence to GAGAS and federal standards. Collaborate with stakeholders to enhance internal controls and audit readiness, drivi...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$172K - $202K *

Unlock potential as a thought leader, generating impactful insights and strategies to address complex client challenges, while mentoring a high-performing team and engaging with stakeholders across va...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Business Services

$104K - $174K *

Champion ecosystem growth by collaborating across teams to enhance partner operations, drive strategic initiatives, and optimize performance metrics, ensuring value delivery to customers and stakehold...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$150K - $230K *

Unlock potential by driving oncology product success through strategic relationships and innovative solutions. Lead market engagement, exceed performance goals, and ensure patient access while embodyi...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$104K - $130K *

Empower growth by transforming complex data into actionable insights. Collaborate with senior leaders to build analytical tools and models that drive strategic decisions, while enhancing operational e...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Engage in cutting-edge AI development by designing and scaling intelligent applications. Leverage Generative AI and modern tools to enhance productivity and integrate workflows within healthcare platf...

United StatesRemote

Reposted 2 days ago

  •   Less than 5 years exp.  •   Healthcare

$58K - $125K *

Accelerate progress at the intersection of finance and strategy, driving cost accounting excellence and profitability analysis. Collaborate with cross-functional teams to enhance financial reporting a...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $160K *

Drive the evolution of a comprehensive content strategy, ensuring alignment across channels to enhance brand authority and trust. Lead editorial governance, manage content operations, and foster cross...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$162K - $214K *

Elevate analytics standards by leading rigorous data practices, ensuring quality, and guiding diverse teams to provide actionable insights. Collaborate with executives and present findings to influenc...

United StatesRemote

Reposted 4 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$92K - $110K *

Transform patient care as a Clinical Practice Leader, driving evidence-based practices and enhancing team collaboration in a dynamic Emergency Medicine environment. Lead initiatives to improve outcome...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$100K - $122K *

Take ownership of financial planning and analysis for G&A expenses, driving insights and reporting for senior leadership. Collaborate with teams to enhance budgeting, forecasting, and variance analysi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Champion clinical project success by leading operations, training teams, and ensuring compliance. Drive strategic planning and risk management while overseeing site performance and fostering collabora...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$129K - $162K *

Develop and lead actuarial processes for Medicare Value-Based Care, managing monthly results, payer settlements, and special projects. Collaborate with cross-functional teams to enhance analytics and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $268K *

Drive state and local government relations across 25 states, managing legislative efforts and stakeholder engagement to advance business goals. Collaborate with internal teams and external partners to...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$83K - $107K *

Elevate digital strategies by integrating user experience with data-driven insights. Collaborate to enhance our online presence, optimize content, and ensure consistency across digital platforms to cr...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$89K - $151K *

Deliver exceptional automation solutions that enhance operational efficiency and accuracy across the healthcare revenue cycle. Lead strategic initiatives to streamline processes, optimize performance...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $180K *

Unlock potential by leading a diverse team of technical professionals to ensure timely project delivery and operational excellence. Drive collaboration, manage risks, and enhance project management pr...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Information Technology

$145K - $152K *

Champion program excellence by leading complex federal initiatives, managing multidisciplinary teams, and fostering strong stakeholder relationships to ensure successful delivery and client satisfacti...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.