Explore $100K+ Jobs in Iowa

Discover professional opportunities across Iowa with Ladders. Browse vetted job listings with salaries of $100,000 or more, from leadership and technology roles to finance, healthcare, engineering, and other specialized careers. Whether you’re considering a move or looking to advance your career close to home, explore opportunities in Iowa’s major employment centers and beyond.

Where to Find Professional Jobs in Iowa

Iowa offers career opportunities in cities and communities throughout the state. Des Moines is a major center for insurance, financial services, healthcare, and corporate leadership. Cedar Rapids and Iowa City have opportunities in technology, advanced manufacturing, education, and healthcare, while other regional hubs support a range of professional and industrial employers. Job availability and compensation vary by role, employer, and location.

In-Demand Fields and Roles

High-paying Iowa jobs can be found across industries such as insurance and finance, healthcare, information technology, engineering, manufacturing, agriculture-related business, and executive management. Employers may seek experienced professionals in areas including software and data, operations, sales, accounting, clinical leadership, and product or project management. Review each posting for its specific qualifications, responsibilities, and compensation details.

Find the Right Iowa Opportunity

Use Ladders to explore vetted professional openings with listed salaries of $100,000 or more. Refine your search by job title, industry, location, and other preferences. Compare roles and employer requirements, then apply to opportunities that align with your experience and career goals. Listings and salary information can change, so check individual postings for the latest details.

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$120K - $150K *

Unlock your potential as a key resource in power plant consulting, focusing on generator engineering. Collaborate with industry leaders to deliver innovative solutions while enjoying a flexible remote...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$181K - $301K *

Transform your career by leading a global cyber defense team, driving proactive strategies to mitigate risks and enhance security across diverse environments. Collaborate with cross-functional teams t...

RemoteRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Transform outpatient behavioral health by joining our dedicated team to provide compassionate care for individuals facing substance use disorders and mental health challenges, while shaping a new prog...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$80K - $100K *

Lead a dynamic team in delivering high-quality veterinary care while fostering professional growth and collaboration. Enjoy a supportive environment with modern resources and opportunities for mentors...

2 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$195K - $244K *

Unlock your potential as a Global Regulatory Leader, driving regulatory strategy and submissions for CNS projects. Collaborate with cross-functional teams, mentor junior staff, and ensure compliance w...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$172K - $202K *

Lead innovative insights and strategies as a Senior Director, driving impactful research and analysis to empower clients in navigating complex market challenges and achieving their business objectives...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Business Services

$148K - $165K *

Transform business outcomes by leading AI initiatives and collaborating across functions to develop innovative solutions that enhance productivity, efficiency, and operational excellence, while drivin...

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$148K - $165K *

Lead the charge in AI innovation by designing and implementing solutions that transform business processes. Collaborate with stakeholders to optimize operations, leveraging your advanced expertise in...

Ankeny, IARemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$132K - $302K *

Elevate your career by leading complex technology programs in healthcare. Drive transformation, engage with senior executives, and deliver measurable outcomes while managing cross-functional teams and...

1 week ago

  •   8 - 10 years exp.  •   Business Services

$230K - $345K *

Shape the future of late-stage oncology clinical trials by leading strategic initiatives, ensuring operational excellence, and fostering cross-functional partnerships to drive successful trial executi...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$83K - $129K *

Lead the charge in advanced compliance activities, ensuring administrative solutions align with laws and regulations. Utilize AI tools to enhance efficiency, guide teams, and deliver scalable complian...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Drive the month-end close process by ensuring accurate revenue recognition and analysis. Collaborate across departments to produce insightful reports and support financial decision-making while adheri...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$179K - $280K *

Unlock potential by driving strategic revenue cycle performance and enhancing client partnerships. Lead initiatives across Self-Pay and Patient Financial Experience, leveraging data to influence decis...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$100K *

Elevate sales strategies by owning the full sales cycle, building C-Suite relationships, and delivering impactful solutions to healthcare organizations across the Western US...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Explore advanced revenue analysis and month-end controls to ensure accurate invoicing and financial reporting. Collaborate across functions to resolve discrepancies, mentor junior analysts, and drive...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$190K - $200K *

Elevate your career by driving sales strategy and execution for a dynamic SaaS portfolio. Lead a high-performing team to achieve revenue growth, optimize pipeline management, and enhance customer acqu...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$150K - $180K *

Champion end-to-end contract management and corporate compliance, driving legal support for commercial and federal agreements while collaborating across departments to ensure efficient deal closure an...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Lead large-scale EPC projects, ensuring safety, quality, and financial success. Drive cross-functional teams and manage stakeholder relationships from pre-construction to close-out, delivering excepti...

3 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$120K - $145K *

Join a team that's dedicated to safeguarding sensitive health information while enhancing security across cloud and application environments. As a Senior Security Engineer, you'll design and implement...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$225K - $418K *

Champion advanced analytics to enhance patient outcomes through data-driven insights. Lead a team in analyzing healthcare data, fostering strategic partnerships, and communicating complex findings to...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$163K - $204K *

Unlock potential by leading innovative machine learning methods for cancer detection, collaborating with experts, and mentoring junior scientists to advance research in multi-cancer early detection us...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$172K - $202K *

Lead the charge in delivering expert guidance on identity and access management technologies, focusing on architecting solutions and producing actionable research to enhance client performance and sec...

RemoteRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Business Services

$85K - $104K *

Champion financial performance analysis for specialty pharmacy, collaborating with cross-functional teams to enhance revenue integrity and profitability through actionable insights and strategic recom...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Drive regulatory strategy across major programs, leading high-impact submissions and authority engagement. Collaborate with cross-functional teams to optimize clinical development and ensure complianc...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Lead the charge in driving complex sales within mid-market organizations, influencing hiring strategies and compliance. Own the full sales cycle, build strong pipelines, and engage with multiple stake...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs are available in Iowa?question toggle

    Openings may include leadership, technology, finance and insurance, healthcare, engineering, sales, and operations roles. Availability depends on employer needs, experience, and location; review current listings for specific opportunities.

  • Which Iowa cities have professional jobs paying $100,000 or more?question toggle

    Des Moines, Cedar Rapids, and Iowa City are among the state’s major employment centers, with professional opportunities also available in other Iowa communities. Search by location to see current openings.

  • How can I find high-paying jobs in Iowa on Ladders?question toggle

    Browse Iowa listings and use filters such as job title, industry, and location. Ladders features vetted professional jobs with salaries of $100,000 or more; check each posting for qualifications and compensation details.

  • Do Iowa job listings on Ladders include salary information?question toggle

    Ladders focuses on jobs with salaries of $100,000 or more. Individual postings provide the available compensation information, which may vary by role and employer.