Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Director, Computer Systems & Operations
$115K - $240K *
Transform operations by leading infrastructure initiatives, enhancing production efficiency, and fostering collaboration across teams to meet business needs while ensuring reliability and modernizing...
Today
Associate Director, Field Reimbursement
$211K - $235K *
Drive patient access initiatives by leveraging oncology expertise to navigate reimbursement landscapes, educate stakeholders, and resolve complex access issues, ensuring timely therapy access for pati...
2 days ago
$147K - $192K *
Tackle new opportunities in the healthcare sector by driving sales and strategy. Engage with C-suite executives, implement effective sales policies, and analyze market trends to maximize revenue growt...
Reposted 1 week ago
Director, Executive Compensation
$156K - $227K *
Elevate executive compensation strategies by designing and leading Total Rewards programs that align with organizational goals, while collaborating with key stakeholders to ensure compliance and effec...
3 days ago
$108K - $130K *
Drive program delivery across multiple products, ensuring timely outcomes by managing risks, dependencies, and stakeholder priorities. Collaborate cross-functionally to maintain accurate project data...
3 weeks ago
Director, Health Plans (Account Executive)
$120K - $135K *
Support the growth of health plan accounts by fostering client relationships, analyzing data, and driving retention in a fast-paced, independent role. Leverage strong communication and analytical skil...
4 weeks ago
Director, Clinical Systems Operations (Pharmacy)
$134K - $249K *
Lead the charge in enhancing clinical systems operations, driving efficiency and effectiveness across pharmacy initiatives while managing a dedicated team and overseeing complex workflows and data int...
Today
$122K - $203K *
Empower teams by leading data governance initiatives, enhancing data quality, and fostering collaboration across business domains. Drive operational excellence and ensure compliance while developing a...
1 week ago
Dir, MAPS (Market Access Patient Services)/Medical Data Partnerships Lead
$185K - $344K *
Join a team that's redefining market access through innovative data partnerships. Lead strategic collaborations, ensure data compliance, and drive insights that enhance decision-making and patient ser...
Reposted 6 days ago
Director, Data Engineering & Analytics
$178K - $294K *
Join a team that's redefining data engineering and analytics. Lead strategy, architecture, and execution of scalable data solutions while mentoring professionals and driving business outcomes through...
Reposted 1 week ago
Sr. Director, Revenue Operations - AMER
$198K - $298K *
Lead the charge in shaping the AMER Revenue Operations strategy, driving operational excellence and predictable outcomes. Collaborate with executive leadership to optimize sales processes and build a...
6 days ago
$100K - $135K *
Lead the charge in delivering complex projects from initiation to close, ensuring alignment among stakeholders, effective risk management, and adherence to timelines while utilizing AI tools to enhanc...
3 weeks ago
$158K - $213K *
Oversee day-to-day accounting and treasury operations, ensuring accuracy and compliance. Lead month-end close processes, refine internal controls, and develop a high-performing team while integrating...
Reposted 1 week ago
Director of Revenue Operations
$150K - $170K *
Optimize revenue operations by partnering with leadership to enhance GTM strategies, manage HubSpot systems, and drive data quality. Lead analytics and reporting while fostering cross-functional align...
Yesterday
Associate Director, US Pricing, Contracting and Channel Strategy
$157K - $256K *
Shape strategic pricing and channel strategies for innovative therapies, ensuring patient access and affordability. Lead cross-functional initiatives, optimize distribution models, and drive market in...
3 days ago
$150K - $180K *
Lead the charge in driving strategic growth by managing a high-performing sales team, refining sales strategies, and fostering a culture of excellence to achieve ambitious revenue goals...
1 week ago
$90K - $110K *
Empower your career by driving project delivery and managing Agile teams. Utilize AI tools to enhance decision-making, anticipate risks, and ensure timely outcomes. Collaborate with stakeholders to ma...
3 weeks ago
$135K - $160K *
Shape the future of K-12 sales by leading a dynamic team of Account Executives. Drive performance through strategic planning, precise forecasting, and collaborative initiatives to achieve growth targe...
1 week ago
$113K - $197K *
Lead regulatory and compliance oversight for Operations, ensuring accuracy and efficiency. Collaborate with enterprise partners to enhance operational processes, implement automation, and drive contin...
6 days ago
Director of Insurance Plan Management
$120K - $150K *
Transform the landscape of dental negotiations by leading strategic partnerships with payers, optimizing contracts, and driving revenue growth through data-driven insights and collaborative execution...
1 week ago
$120K - $150K *
Unlock operational excellence by leading multi-site Ambulatory Surgery Centers. Drive growth strategies, optimize performance, and foster strong partnerships with physician leaders while managing sign...
Reposted 1 week ago
Director, Business Improvement
$150K - $180K *
Drive strategic initiatives and operational excellence across a global portfolio, partnering with leadership to enhance business performance and deliver measurable outcomes in oncology and rare diseas...
1 week ago
Director - Performance Transformation
$206K - $343K *
Lead the charge in transforming healthcare operations by delivering innovative performance solutions. Drive profitable growth through strategic program management and client engagement, ensuring measu...
Yesterday
Director, Client Coding Integration
$97K - $145K *
Join a dynamic team to lead physician coding integration initiatives, ensuring operational readiness and compliance. Collaborate across departments to enhance coding practices and drive revenue cycle...
Today
Director, Client Coding Integration
$120K - $145K *
Execute accurate coding practices to ensure compliance and optimal reimbursement in a dynamic healthcare environment. Collaborate with clinical teams to maintain integrity and efficiency in revenue cy...
Reposted 1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.