Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Director of Business Development , Research & Intelligence
$275K - $350K *
Lead the charge in building a subscription research business, driving sales and market strategy across energy, trading, and institutional sectors. Collaborate with analysts to tailor offerings and est...
1 week ago
Senior Director, Web Strategy and Operations
$160K - $200K *
Shape the future of our web strategy by leading a cross-functional team to optimize user experience, drive demand generation, and enhance web performance. Your expertise will transform our website int...
2 weeks ago
Director of E-Commerce & Digital Product
$130K - $160K *
Elevate digital experiences by guiding site operations and enhancing user engagement. Collaborate with cross-functional teams to implement innovative features and optimize performance metrics, driving...
Reposted today
GIS / Real Property Project Manager
$100K - $120K *
Empower a team by leading GIS and Real Property projects, enhancing data quality and usability for Army installations. Collaborate with stakeholders to deliver innovative geospatial solutions and ensu...
3 weeks ago
$107K - $199K *
Lead transformative process improvements to enhance healthcare quality and efficiency. Collaborate with teams to elevate performance metrics, oversee cultural competency initiatives, and drive strateg...
Reposted 6 days ago
Digital Solutions Development Manager
$125K - $150K *
Drive software engineering initiatives by leading teams to deliver innovative digital solutions. Define technology strategy, oversee development processes, and foster a culture of excellence and colla...
2 weeks ago
Group Product Management Manager
$236K - $296K *
Lead innovative product initiatives by owning vision, strategy, and execution. Collaborate with cross-functional teams to transform ideas into scalable solutions, driving impactful outcomes for the co...
2 weeks ago
Director, Consulting & Advisory Alliances, North America
$150K - $170K *
Join a team that's expanding strategic partnerships with consulting firms to enhance supply chain solutions. Drive growth through collaboration, relationship management, and innovative go-to-market st...
1 week ago
Senior Technical Product Manager
$130K - $180K *
Join a team that's redefining data products on a modern platform. As a Senior Technical Product Manager, you'll drive the strategy for our data platform and API, ensuring quality, governance, and a se...
3 weeks ago
Manager - Business Development (IP & IP Litigation)
$100K - $130K *
Champion strategic growth by collaborating with practice groups to enhance business development initiatives, drive revenue, and support client engagement. Play a key role in shaping marketing strategi...
Reposted 5 days ago
Training and Development Manager
$80K - $95K *
Drive impactful training initiatives that enhance employee performance and student engagement. Lead the development of scalable onboarding and continuous learning programs, collaborating with cross-fu...
Yesterday
Information Protection Advisor - SSP & CMMC Programs
$103K - $171K *
Elevate security compliance by collaborating with cross-functional teams to maintain accurate documentation and support federal compliance initiatives, ensuring systems meet evolving cybersecurity sta...
4 weeks ago
Director, Revenue Accounting and Finance
$201K - $251K *
Shape the future of revenue accounting by leading critical processes and driving scalable methodologies to support commercial growth. Collaborate with cross-functional teams to deliver actionable fina...
3 weeks ago
Associate Director, Business Development (Creative Tools, Game Development, and Learning)
$110K - $155K *
Unlock potential by leading strategic partnerships in Creative Software Licensing. Drive growth through innovative deals, build relationships with developers, and shape the future of digital tools for...
2 weeks ago
$95K - $115K *
Lead and enhance day-to-day accounting operations, focusing on accounts payable, receivable, and cash management. Collaborate with cross-functional teams to ensure accurate, timely transactions while...
2 weeks ago
$120K - $165K *
Elevate your career as a Scientific Product Owner, driving innovation in clinical genomics software. Collaborate with cross-functional teams to translate scientific needs into actionable requirements...
2 weeks ago
Project Manager lll - Data Center and Mission Critical
$118K - $147K *
Unlock potential by leading cross-functional teams in mission-critical projects. Oversee deliverables, manage client relationships, and drive strategic business development while ensuring project obje...
4 days ago
Staff Product Manager, Technical
$160K - $220K *
Shape the future of product strategy by leading complex client engagements, managing the full product lifecycle, driving cross-functional alignment, and mentoring teams to deliver impactful solutions...
Reposted 4 weeks ago
Director, Commercial Sales Performance Management
$128K - $268K *
Unlock potential by leading risk management for Commercial Card and Merchant Services. Collaborate across teams to assess risks, enhance controls, and ensure compliance, driving strategic growth and o...
Reposted 2 days ago
Design and Submittal Manager - Lake City Microgrid and CHP
$100K - $120K *
Lead multidisciplinary design management for industrial power projects. Own submittal processes, coordinate reviews, and ensure compliance with design interfaces and approvals to drive project success...
2 weeks ago
Healthcare Senior Project Manager- Construction
$110K - $130K *
Optimize project delivery in healthcare construction by leading teams, managing risks, and ensuring compliance with regulatory standards. Drive client relationships and mentor junior staff while achie...
Reposted 1 week ago
Associate Director / Senior Managing Consultant - Financial Services Operations & Technology
$150K - $250K *
Transform financial services by leading complex banking operations and technology projects. Collaborate with clients to enhance performance, drive innovation, and shape a new practice within a dynamic...
2 weeks ago
$110K - $130K *
Transform the future of hygienic sensors by leading product strategy, collaborating with engineering, and driving market success. Engage with customers and stakeholders to ensure product alignment wit...
2 weeks ago
Project Manager, Cybersecurity - Remote
$95K - $115K *
Empower your career by managing diverse Cybersecurity projects from initiation to completion. Collaborate with teams, engage clients, and ensure project success through effective planning and executio...
4 days ago
$150K - $180K *
Elevate data privacy standards by leading a comprehensive privacy program. Collaborate across teams to integrate privacy-by-design principles, enhance data governance, and ensure compliance while enab...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.