Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$275K - $350K *

Lead the charge in building a subscription research business, driving sales and market strategy across energy, trading, and institutional sectors. Collaborate with analysts to tailor offerings and est...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$160K - $200K *

Shape the future of our web strategy by leading a cross-functional team to optimize user experience, drive demand generation, and enhance web performance. Your expertise will transform our website int...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $160K *

Elevate digital experiences by guiding site operations and enhancing user engagement. Collaborate with cross-functional teams to implement innovative features and optimize performance metrics, driving...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Empower a team by leading GIS and Real Property projects, enhancing data quality and usability for Army installations. Collaborate with stakeholders to deliver innovative geospatial solutions and ensu...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$107K - $199K *

Lead transformative process improvements to enhance healthcare quality and efficiency. Collaborate with teams to elevate performance metrics, oversee cultural competency initiatives, and drive strateg...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $150K *

Drive software engineering initiatives by leading teams to deliver innovative digital solutions. Define technology strategy, oversee development processes, and foster a culture of excellence and colla...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$236K - $296K *

Lead innovative product initiatives by owning vision, strategy, and execution. Collaborate with cross-functional teams to transform ideas into scalable solutions, driving impactful outcomes for the co...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$150K - $170K *

Join a team that's expanding strategic partnerships with consulting firms to enhance supply chain solutions. Drive growth through collaboration, relationship management, and innovative go-to-market st...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$130K - $180K *

Join a team that's redefining data products on a modern platform. As a Senior Technical Product Manager, you'll drive the strategy for our data platform and API, ensuring quality, governance, and a se...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Staffing

$100K - $130K *

Champion strategic growth by collaborating with practice groups to enhance business development initiatives, drive revenue, and support client engagement. Play a key role in shaping marketing strategi...

Reposted 5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$80K - $95K *

Drive impactful training initiatives that enhance employee performance and student engagement. Lead the development of scalable onboarding and continuous learning programs, collaborating with cross-fu...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$103K - $171K *

Elevate security compliance by collaborating with cross-functional teams to maintain accurate documentation and support federal compliance initiatives, ensuring systems meet evolving cybersecurity sta...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$201K - $251K *

Shape the future of revenue accounting by leading critical processes and driving scalable methodologies to support commercial growth. Collaborate with cross-functional teams to deliver actionable fina...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $155K *

Unlock potential by leading strategic partnerships in Creative Software Licensing. Drive growth through innovative deals, build relationships with developers, and shape the future of digital tools for...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$95K - $115K *

Lead and enhance day-to-day accounting operations, focusing on accounts payable, receivable, and cash management. Collaborate with cross-functional teams to ensure accurate, timely transactions while...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$120K - $165K *

Elevate your career as a Scientific Product Owner, driving innovation in clinical genomics software. Collaborate with cross-functional teams to translate scientific needs into actionable requirements...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$118K - $147K *

Unlock potential by leading cross-functional teams in mission-critical projects. Oversee deliverables, manage client relationships, and drive strategic business development while ensuring project obje...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$160K - $220K *

Shape the future of product strategy by leading complex client engagements, managing the full product lifecycle, driving cross-functional alignment, and mentoring teams to deliver impactful solutions...

RemoteRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$128K - $268K *

Unlock potential by leading risk management for Commercial Card and Merchant Services. Collaborate across teams to assess risks, enhance controls, and ensure compliance, driving strategic growth and o...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $120K *

Lead multidisciplinary design management for industrial power projects. Own submittal processes, coordinate reviews, and ensure compliance with design interfaces and approvals to drive project success...

2 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$110K - $130K *

Optimize project delivery in healthcare construction by leading teams, managing risks, and ensuring compliance with regulatory standards. Drive client relationships and mentor junior staff while achie...

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$150K - $250K *

Transform financial services by leading complex banking operations and technology projects. Collaborate with clients to enhance performance, drive innovation, and shape a new practice within a dynamic...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Transform the future of hygienic sensors by leading product strategy, collaborating with engineering, and driving market success. Engage with customers and stakeholders to ensure product alignment wit...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$95K - $115K *

Empower your career by managing diverse Cybersecurity projects from initiation to completion. Collaborate with teams, engage clients, and ensure project success through effective planning and executio...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Elevate data privacy standards by leading a comprehensive privacy program. Collaborate across teams to integrate privacy-by-design principles, enhance data governance, and ensure compliance while enab...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.