Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$120K - $145K *

Join a team that's dedicated to managing complex programs, ensuring client satisfaction and operational efficiency. Lead daily operations, supervise staff, and contribute to strategic initiatives whil...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$191K - $247K *

Develop and oversee advanced capabilities in Commercial Learning & Development, driving strategy, implementation, and continuous improvement to enhance field performance and support business objective...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$82K - $229K *

Lead the charge in managing creative projects from inception to delivery, ensuring alignment with brand standards. Collaborate across teams to optimize workflows and maintain quality control for all a...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$80K - $95K *

Champion superior client service by managing eDiscovery projects, coordinating teams, and strategizing solutions to meet client goals. Build strong relationships and ensure seamless communication betw...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$223K - $290K *

Lead the technical strategy for data products, driving clinical data capabilities and insights. Collaborate with teams to optimize data ingestion processes and implement AI-assisted development workfl...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Healthcare

$185K - $344K *

Advance enterprise patient intelligence by leading strategy, governance, and analytics. Collaborate across functions to enhance decision-making and drive insights that improve patient outcomes and bus...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$124K - $187K *

Join a dynamic team as a Project Manager, overseeing complex renewable energy projects and ensuring safety, quality, and budget objectives across multiple disciplines and stakeholders to drive sustain...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$120K - $145K *

Unlock potential by leading strategic partnerships and driving growth initiatives. Collaborate cross-functionally to enhance business opportunities and ensure partner success through data-driven insig...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $115K *

Lead civil engineering projects by collaborating with clients and teams to deliver innovative solutions in site development, drainage, and roadway design. Manage budgets, schedules, and project scopes...

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $95K *

Oversee all construction activities from inception to move-in, ensuring quality control, cost management, and adherence to schedules while collaborating with trade partners and internal teams to optim...

5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$180K - $205K *

Drive financial excellence by delivering insights and analysis for the Field Service organization. Collaborate across departments to enhance forecasting, budgeting, and operational efficiency while su...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Energy & Utilities

$126K - $137K *

Drive the development and management of innovative software products and applications, overseeing their lifecycle from planning to release. Collaborate with stakeholders to ensure product value, usabi...

Today

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Lead the charge in managing complex employment litigation and discovery processes. Collaborate with cross-functional teams to ensure timely, high-quality results while enhancing legal project manageme...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$131K - $204K *

Lead the charge in managing multi-party project interfaces, ensuring timely delivery and adherence to scope and budget. Supervise a dedicated team while driving continuous improvement in project manag...

2 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $180K *

Engage with key healthcare clients to drive strategic account management, fostering relationships and delivering tailored solutions across GE HealthCare’s diverse portfolio, while leading cross-functi...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$150K - $235K *

Join a team that's redefining business processes through digital transformation. Lead cross-functional initiatives, ensuring scalable and standardized practices that align with strategic goals while f...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$115K - $130K *

Lead the Archibus platform for a major Life Sciences client, driving enhancements and integrations while ensuring data integrity and user satisfaction. Collaborate with cross-functional teams to optim...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$110K - $155K *

Lead content operations for a federal web services program, managing a team to ensure timely, accurate, and accessible communication. Drive strategic planning, oversee Drupal content management, and e...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$130K - $150K *

Advance your career by leading product strategy for supply chain orchestration. Drive technical decisions, collaborate with cross-functional teams, and leverage AI to enhance workflows, ensuring measu...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $160K *

Innovate by leading global Credit & Collections operations, driving cash performance, and managing customer credit risk. Collaborate with cross-functional teams to enhance processes, ensure compliance...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$94K - $266K *

Join us to lead innovative cloud-based contact center projects, driving success for Mid-Market & Enterprise clients. Utilize your project management expertise to deliver cutting-edge solutions and fos...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Information Technology

$220K - $260K *

Transform your career by leading product strategy and execution for payment solutions. Drive innovation in payment workflows, enhance reliability, and optimize operational efficiency while collaborati...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $160K *

Shape your career by leading projects in power system planning. Collaborate with clients to navigate regulatory challenges and enhance energy strategies, while managing teams and driving innovative so...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$180K - $200K *

Reimagine security engineering leadership by guiding strategic initiatives across cloud and infrastructure security, enhancing detection engineering, and fostering collaboration to protect a multi-clo...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$185K - $255K *

Transform the financial engine of R&D by leading revenue strategies, pricing, and cost management. Collaborate with senior leaders to align short-term goals with long-term product vision, while buildi...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.