Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Director of Engineering - Global, Remote
$150K - $180K *
Lead and scale a dynamic engineering organization, driving execution and innovation while mentoring managers and aligning cross-functional priorities to deliver impactful solutions...
3 days ago
$140K - $170K *
Join a dynamic team to optimize operational systems, drive growth, and enhance performance across departments. Collaborate with leadership to ensure strategic goals translate into measurable results a...
2 weeks ago
Senior Manager, Design Delivery - USA
$125K - $150K *
Accelerate progress at the forefront of AI factory design delivery, leading multidisciplinary teams to ensure successful project execution from concept to handover while balancing quality, cost, and o...
2 weeks ago
Sr. Director, eDiscovery Technology & AI
$156K - $195K *
Champion the global eDiscovery Technology practice, leading a diverse team to innovate AI-assisted workflows, ensuring defensibility and quality across jurisdictions while driving growth and operation...
2 weeks ago
Organizational Change Management (OCM) Lead
$95K - $120K *
Shape the future of organizational change management by leading initiatives that enhance operations and support Medicaid modernization. Collaborate with teams to ensure successful adoption of new proc...
4 days ago
$103K - $146K *
Join a team that's driving innovation in construction management. Oversee project profitability and success from estimates to completion, ensuring quality and timely delivery while fostering strong re...
2 days ago
Senior Proposal & Pursuit Manager
$105K - $130K *
Lead the proposal development process, enhancing strategies and systems to elevate submissions. Collaborate with executives and technical experts to create compelling, client-focused proposals that sh...
2 weeks ago
Senior Director, Strategic Growth
$150K - $180K *
Drive strategic growth by leading business development and sales operations, optimizing RFP processes, and enhancing performance metrics. Collaborate across teams to ensure alignment and improve outco...
5 days ago
Senior Manager, Global Meeting Planning
$145K - $168K *
Drive impactful medical congress operations by leading planning, execution, and cross-functional collaboration. Own vendor relationships and budgets while ensuring compliance and delivering high-quali...
4 weeks ago
Director, Technical Experience
$135K - $160K *
Drive the strategic vision for Technical Support, enhancing service delivery and operational efficiency while championing AI transformation and innovation to elevate customer experience and achieve bu...
Reposted 1 week ago
Sr. Capture Manager (Enterprise Pursuits)
$120K - $145K *
Champion strategic growth by leading major enterprise pursuits, fostering collaboration, and driving consultative sales processes. Leverage your expertise to develop winning strategies and ensure oper...
1 week ago
Senior Director, DMPK Project Leader
$177K - $338K *
Champion DMPK project leadership by ensuring high-quality data delivery and supporting drug candidate progression through innovative modeling and cross-functional collaboration in a dynamic biotech en...
Reposted 1 week ago
Interior Design - Sr. Project Manager
$88K - $105K *
Elevate design excellence by leading complex projects from inception to completion. Collaborate with clients, manage budgets, and ensure timely delivery while fostering a results-driven team environme...
1 week ago
Senior Director, Research Technology
$134K - $224K *
Shape the future of clinical research technology by leading cross-functional teams to develop innovative solutions that enhance user experience and drive operational excellence in global clinical tria...
Yesterday
$77K - $91K *
Shape the future of project management by leading initiatives that exceed expectations, ensuring timely communication, and fostering collaboration across teams while managing risks and delivering resu...
2 weeks ago
Global Procurement Director - MRO Maintenance & Damage (Remote)
$180K - $220K *
Advance global procurement initiatives by leading sourcing strategies for MRO and automotive parts. Drive operational excellence, enhance supplier relationships, and ensure compliance while achieving...
Reposted 2 days ago
$110K - $130K *
Accelerate progress at national partnerships by leading fundraising initiatives, securing multi-million-dollar commitments, and cultivating relationships with corporate and foundation leaders to suppo...
Today
Director of Accounting Operations
$115K - $135K *
Shape the future of our Accounting Operations by leading a dynamic team, ensuring accuracy and efficiency in financial processes, and driving improvements through automation and AI integration...
2 weeks ago
Deputy Project Manager and EPC Interface Manager - Lake City Microgrid and CHP
$100K - $120K *
Join us in managing complex EPC interfaces and project execution for a critical microgrid initiative. Collaborate across teams to ensure timely delivery and adherence to safety standards while standin...
2 weeks ago
$120K - $150K *
Transform financial operations by leading a dynamic team, ensuring accurate reporting, and driving strategic decisions that enhance value and growth in a fast-paced healthcare environment. Partner clo...
3 days ago
National Process Excellence Director
$125K - $150K *
Join us to lead national process improvement initiatives, fostering operational excellence across diverse teams. Drive efficiencies, document workflows, and empower stakeholders, ensuring alignment wi...
Reposted 6 days ago
Senior Manager, Solutions Consulting
$230K - $280K *
Lead a high-performing team to enhance Solutions Consulting, drive cross-functional collaboration and ensure the success of strategic accounts through innovative, accountable deal execution and contin...
Reposted 4 weeks ago
Applications Management Director
$145K - $175K *
Elevate enterprise application strategy by leading a dynamic team to align technology with business goals, ensuring optimal portfolio management, user experience, and measurable outcomes for sustained...
4 days ago
$101K - $154K *
Shape product strategy and commercialization efforts, ensuring alignment with market trends and customer needs. Drive product development, marketing initiatives, and cross-functional collaboration to...
3 weeks ago
$85K - $100K *
Join us to empower senior leaders by managing complex projects, client contracts, and travel arrangements. Your proactive support will enhance team efficiency in a fully virtual environment, fostering...
4 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.