Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$162K - $243K *
Join a team that's dedicated to advancing clinical trials through strategic oversight and collaboration. Lead project management efforts globally, ensuring quality, cost, and timeline objectives are m...
2 weeks ago
Executive Director, Project Management - Oncology
$203K - $304K *
Champion project success by leading a team of Directors and Managers to drive clinical study strategies, ensuring quality, scope, and budget goals are met while fostering collaboration and continuous...
Today
Executive Director, Project Management - Oncology
$203K - $304K *
Manage a team of Directors to drive clinical study projects, ensuring quality, scope, and budget targets are met while fostering collaboration and strategic alignment across global initiatives...
Yesterday
Associate Director, Project Management
$105K - $120K *
Elevate project management excellence by leading a dynamic team, ensuring high-quality execution across flagship accounts, and driving operational efficiency through strategic oversight and collaborat...
1 month ago
$90K - $100K *
Transform software delivery by managing cross-functional teams, aligning sprints, and optimizing project timelines. Drive clarity in processes and foster collaboration to ensure successful product exe...
Reposted 3 weeks ago
Project Management Director, Facilities
$160K - $200K *
Elevate project delivery by leading a national team managing complex client portfolios. Drive strategic growth, ensure compliance, and foster a collaborative culture while navigating challenges with c...
3 weeks ago
$84K - $112K *
Elevate project delivery by leading complex customer implementations from planning to execution. Collaborate with teams and stakeholders to ensure timely, on-budget solutions while managing risks and...
Yesterday
$162K - $243K *
Shape the future of clinical research by leading cross-functional teams to optimize project delivery, ensuring quality and compliance while managing resources and budgets effectively across global cli...
Reposted 1 week ago
Director, Commercial Project Management
$201K - $251K *
Join us to lead cross-functional project management in a dynamic biotech environment. Drive global commercialization initiatives, ensuring alignment and execution across teams while enhancing operatio...
3 weeks ago
Manager Project Management (PMO) North America
$120K - $145K *
Champion operational excellence by leading PMO governance and performance management initiatives. Drive cross-functional collaboration to enhance project execution, forecasting accuracy, and backlog c...
2 days ago
$100K - $120K *
Lead the charge in optimizing project management processes for a VHA client team. Utilize your expertise to enhance strategic planning, decision-making, and execution while collaborating with senior s...
4 weeks ago
$135K - $148K *
Drive the successful delivery of complex enterprise projects, ensuring timely execution and high-quality standards. Collaborate cross-functionally to meet client objectives and enhance project managem...
2 days ago
$95K - $115K *
Empower a dynamic team of Project Managers to drive successful product implementations, enhance operational efficiency, and achieve key performance metrics while fostering cross-functional collaborati...
4 days ago
Senior Manager, PMO (P&C Insurance)
$140K - $175K *
Lead transformative insurance program initiatives, overseeing technology enhancements and operational workflows. Collaborate across teams to drive project management and ensure compliance, while optim...
Reposted 3 days ago
$100K - $120K *
Pioneer innovative eDiscovery solutions by managing complex projects, collaborating with legal teams, and mentoring staff. Ensure quality deliverables while exceeding client expectations through exper...
3 weeks ago
Senior Manager, Project Management Academy
$110K - $130K *
Elevate your career by leading the Global PM Academy's strategy and governance. Design impactful learning programs and ensure compliance across platforms while driving continuous improvement in projec...
2 weeks ago
Project Management Director, Construction
$160K - $230K *
Lead and empower a dedicated project management team to deliver exceptional service across a diverse portfolio, driving strategic growth and fostering strong client relationships while navigating comp...
Reposted 2 days ago
Director, Head of Project Execution, Digital Technologies
$120K - $145K *
Innovate digital experiences by leading project execution across technology portfolios. Collaborate with business and tech leaders to drive priorities, enhance capabilities, and deliver exceptional me...
3 weeks ago
Director of Project Management & Controls
$175K - $225K *
Drive the development of project management functions, overseeing complex construction projects while ensuring financial performance, team growth, and operational excellence in a fast-paced environmen...
Today
$137K - $171K *
Drive revenue growth by leading a high-performing sales team focused on expanding existing customer accounts. Collaborate cross-functionally to align strategies and enhance net revenue retention while...
4 days ago
$126K - $171K *
Lead the charge in delivering innovative project management solutions for large law firms. Drive implementations, manage resources, and ensure client satisfaction while navigating complex challenges a...
3 weeks ago
Project Manager - Institutional
$95K - $115K *
Lead the charge in delivering complex healthcare construction projects, ensuring safety, budget adherence, and compliance. Collaborate with multidisciplinary teams to enhance patient care while managi...
Reposted 4 days ago
Senior Project Manager, Promotional Medical Education
$90K - $100K *
Accelerate progress at a dynamic agency by leading complex client campaigns. Manage project scope, timelines, and budgets while collaborating with cross-functional teams to deliver high-quality result...
Reposted 3 weeks ago
Senior Manager, Strategic Project Management
$117K - $206K *
Lead strategic initiatives from inception to delivery, driving cross-functional collaboration and leveraging AI tools to enhance project outcomes. Partner with executives to ensure alignment and measu...
Yesterday
Senior Project Manager, Scrum Master
$130K - $140K *
Lead the charge in delivering enterprise data platform initiatives, managing Agile processes, and ensuring effective collaboration across teams. Drive project execution from discovery to deployment wh...
2 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.