Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$95K - $115K *

Unlock potential by enhancing marketing operations and driving efficiency across teams. Collaborate closely with leadership to identify process improvements, analyze performance data, and streamline w...

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$126K - $189K *

Join a team that's leading provider enrollment operations, ensuring timely onboarding, compliance, and accuracy. Drive strategic initiatives and enhance operational efficiency across networks while co...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$174K - $374K *

Lead the Medicare Appeals team, overseeing daily operations and ensuring compliance. Collaborate with healthcare professionals to enhance efficiency and provide expert guidance on Medicare policies wh...

Connecticut, USRemote

Reposted 4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Champion client relationships and optimize pharmaceutical distribution projects, leveraging extensive industry expertise to deliver high-quality solutions and insights while managing multiple accounts...

Florida, USRemote

Today

  •   8 - 10 years exp.  •   Media

$118K - $158K *

Transform the CEO's office by driving strategic initiatives, managing executive priorities, and fostering cross-functional collaboration. Leverage your expertise to enhance decision-making and operati...

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$165K - $205K *

Transform centralized revenue cycle operations by leading multiple teams, ensuring quality service delivery, compliance, and financial performance while driving continuous improvement and automation a...

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$107K - $199K *

Join a team that's driving strategic initiatives and operational excellence. This role collaborates with senior leadership to enhance growth plans, manage impactful projects, and ensure alignment acro...

Oregon, USRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$275K - $345K *

Elevate clinical pharmacology strategy across oncology trials, leading cross-functional teams to optimize dose selection, regulatory submissions, and DMPK oversight while building a high-performing in...

Today

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$169K - $219K *

Lead the charge in managing a high-performing team to drive customer success, retention, and growth within a dedicated portfolio. Oversee strategic initiatives, operational excellence, and executive p...

Toronto, ONIn-Person

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$148K - $232K *

Empower operational excellence by leading diverse clinical programs, ensuring quality services, and fostering a healthy work environment. Collaborate with clinical leadership to implement strategic po...

6 days ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$137K - $235K *

Join a team that's shaping the future of ophthalmology by leading clinical trials and driving innovative research strategies. Collaborate with cross-functional experts to enhance clinical development...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$137K - $235K *

Drive innovative clinical strategies in ophthalmology, managing complex trials and collaborating with cross-functional teams to enhance patient outcomes and operational excellence in early drug develo...

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$126K - $169K *

Transform compliance and ethics at a strategic level, leading initiatives that enhance privacy, governance, and risk management while fostering a culture of integrity and accountability across the org...

Mississauga, ONIn-Person

Yesterday

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Empower program development and lead a clinical team in providing exceptional neurorehabilitation services. Ensure compliance, implement quality assurance, and promote a culture of continuous improvem...

3 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Transform clinical operations by leading a dynamic team, ensuring high-quality trial management, and driving innovation through technology and AI solutions. Foster collaboration and accountability whi...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$149K - $166K *

Lead the charge in regulatory operations, ensuring timely, high-quality submissions to global health authorities. Collaborate with cross-functional teams to manage project timelines, risks, and compli...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $190K *

Join a dynamic team to lead global clinical development programs, ensuring successful site startup and operational excellence while fostering high-performance cultures and strategic partnerships acros...

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$322K - $439K *

Lead the charge in shaping global drug safety strategy, overseeing a high-performing team of safety physicians. Drive benefit-risk assessments and influence key decisions across the development pipeli...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$90K - $100K *

Champion clinical nutrition excellence by leading a dynamic team across multiple facilities. Drive innovative programs, enhance patient care, and ensure compliance while fostering a collaborative envi...

6 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$132K - $182K *

Unlock potential by leading the development and maintenance of dashboards for Market Access teams, ensuring accurate data and insights to drive strategic decisions and enhance operational effectivenes...

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Transform the future of healthcare by leading Occupational Health and Urgent Care Clinics, ensuring high-quality patient care, effective staffing, and strategic program development while fostering a c...

2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$80K - $95K *

Pioneer high-quality nursing care by mentoring staff, ensuring compliance, and implementing best practices. Collaborate with management to enhance patient outcomes and foster a positive work environme...

4 days ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$175K - $250K *

Drive medical leadership for early-phase clinical programs, focusing on innovative genetic therapies. Collaborate with cross-functional teams to ensure safety and efficacy in trials, while authoring k...

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $100K *

Accelerate progress at the forefront of home care by leading nursing teams, ensuring quality patient care, and fostering collaboration among staff, families, and healthcare providers to enhance clinic...

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$108K - $130K *

Lead the charge in operational excellence and strategic growth at an imaging center, ensuring high-quality patient care, financial performance, and a collaborative work environment while driving initi...

Yesterday

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.