Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$93K - $120K *

Join a dynamic team as you manage clinical data throughout study lifecycles, ensuring compliance and quality. Collaborate with cross-functional teams to drive data strategy and support innovative solu...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$210K - $250K *

Innovate in AI-native primary care by leading a dynamic medical group. Manage physicians, enhance care delivery, and shape clinical programs while maintaining direct patient care involvement. Drive ex...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$159K - $211K *

Join us in transforming quality operations by leading a robust PACE quality program, ensuring compliance and care excellence while collaborating cross-functionally to enhance participant outcomes and...

California, USRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$262K - $284K *

Optimize pediatric drug development strategies as a clinical pharmacology leader, overseeing pharmacometric analyses and regulatory submissions, while translating complex data into actionable decision...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a team that's dedicated to creating impactful medical education content for healthcare providers and patients. Collaborate closely with scientific and account teams to deliver high-quality materi...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in clinical study start-up operations, driving team development and ensuring timely site activation. Collaborate cross-functionally to enhance processes, meet regulatory standards, and...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$181K - $200K *

Champion transformative call center operations by leading strategic outreach, workforce management, and capacity planning. Drive efficiency and quality through innovative automation and AI solutions w...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $160K *

Join a team that's dedicated to crafting and implementing effective patient support programs. As a strategic leader, you will drive program design, coordinate stakeholder engagement, and ensure succes...

North Carolina, USRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $150K *

Elevate your career by leading clinical trial management teams, ensuring quality and compliance in monitoring strategies. Collaborate with cross-functional teams to optimize clinical operations and dr...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$220K - $280K *

Lead the charge in medical strategy excellence, overseeing team growth and client relationships while translating complex medical insights into actionable brand strategies across diverse therapeutic a...

New York, NYRemote

2 days ago

  •   8 - 10 years exp.  •   Media

$175K - $200K *

Lead the charge in optimizing biomarker program operations, ensuring seamless sample processing from collection to storage. Collaborate across teams to uphold quality and compliance while driving grow...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$115K - $183K *

Shape transformative clinical programs and patient engagement strategies, ensuring sustainable outcomes across care settings. Lead a dynamic team while partnering with executives to enhance patient ex...

Anchorage, AKRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$195K - $277K *

Drive innovative clinical oncology studies by designing protocols, collaborating with teams, and ensuring compliance with regulations. Leverage expertise to analyze data, support publications, and mai...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $200K *

Drive impactful change in healthcare consulting by leveraging your expertise in clinical operations and research administration. Collaborate with executive leaders to solve complex challenges and fost...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$246K - $332K *

Transform the future of field operations by leading strategic initiatives that enhance commercial effectiveness and drive measurable impact across customer-facing teams. Collaborate with cross-functio...

RemoteRemote

6 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$195K - $341K *

Empower healthcare delivery by leading clinical reviews, provider education, and quality improvement initiatives. Collaborate with teams to enhance member care standards and support compliance with re...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$195K - $341K *

Engage in clinical oversight and support staff training while ensuring adherence to quality standards and regulatory compliance in a collaborative healthcare environment focused on member care and ope...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Join a team that's revolutionizing revenue operations by owning HubSpot, building scalable systems, and driving growth through integrated data management. This hands-on role is pivotal in shaping our...

Cincinnati, OHRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$129K - $162K *

Unlock potential by leading enterprise-wide Cost of Care solutions. Drive scalability, optimize deployment, and enhance operational effectiveness across diverse markets, collaborating with stakeholder...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$156K - $215K *

Drive data quality and integrity initiatives by leading cross-functional teams to enhance provider data management practices, ensuring compliance and operational excellence across the organization...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$126K - $234K *

Elevate patient advocacy efforts by building strategic partnerships within Neuromuscular communities to enhance care and reduce access barriers, ensuring patient insights inform corporate strategy and...

East Hanover, NJRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join our team to enhance patient access and streamline operational processes, driving meaningful improvements through data analysis, project management, and collaboration across departments while fost...

North Carolina, USRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$215K - $408K *

Join a team that's dedicated to enhancing medical management and quality improvement. Collaborate with clinical teams to optimize patient care, support performance initiatives, and drive effective uti...

Georgia, USRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$215K - $408K *

Lead the charge in enhancing medical management and quality improvement. Drive utilization review, collaborate with providers, and implement performance initiatives to optimize care quality and cost-e...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Reimagine client partnerships by managing complex relationships, driving performance, and leading recovery strategies. Collaborate with executives to ensure client success and identify growth opportun...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.