Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$160K - $190K *

Elevate healthcare solutions by transforming complex data needs into scalable systems. Collaborate with cross-functional teams to design and build data pipelines and insightful dashboards that enhance...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Transform claims management by leading strategic initiatives, overseeing operations, and driving continuous improvement across a diverse portfolio, ensuring optimal outcomes and compliance while colla...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$107K - $166K *

Elevate healthcare engagement by connecting with providers through innovative tools, enhancing patient care and experiences. Collaborate with cross-functional teams to drive insights and strategic dec...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion operational excellence by leading communication strategies and process improvements. Collaborate with leadership and teams to ensure effective information flow and accountability, driving ini...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$78K - $113K *

Join us in transforming Revenue Cycle Management by leveraging analytical skills to enhance operational excellence across various RCM functions, driving process improvements and supporting financial p...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead the charge in delivering exceptional client services for high-value accounts. Develop integrated marketing strategies, oversee multidisciplinary teams, and drive account growth while ensuring qua...

Lanham, MDRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Media

$168K - $240K *

Lead total rewards strategy for a complex global healthcare tech firm. Drive compensation and benefits governance, align workforce investment with business goals, and ensure compliance while fostering...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by leading operational excellence and customer satisfaction across multiple markets. Drive performance, coach leaders, and implement continuous improvement initiatives to enhance serv...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Transportation

$163K - $218K *

Lead the strategy and delivery of enterprise applications, optimizing technology platforms to enhance clinical care and business operations. Collaborate with cross-functional teams to drive improvemen...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Take ownership of operations to enhance performance, customer satisfaction, and continuous improvement. Lead support teams, manage incidents, and ensure compliance with standards while driving account...

Nashville, TNRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$125K - $150K *

Transform vendor performance management by overseeing external hub partners, ensuring compliance with SLAs and quality standards while driving operational excellence and continuous improvement to enha...

North Chicago, ILRemote

4 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$171K - $265K *

Strategize and lead the operations technology vision, driving modernization and innovation across platforms to enhance business outcomes in customer service, claims, and digital solutions, while foste...

Richmond, VARemote

2 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$80K - $95K *

Drive the operations of case management with a focus on quality service and leadership. Leverage your clinical experience and supervisory skills to enhance team performance, ensuring efficient managem...

Downers Grove, ILRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Staffing

$132K - $172K *

Lead pharmacovigilance operations and safety science initiatives, ensuring compliance and quality in drug safety reporting. Oversee vendor performance, manage safety data, and contribute to regulatory...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $110K *

Drive operational excellence by leading the Customer Success Operations team, ensuring efficient service delivery, performance management, and continuous improvement across multiple programs to enhanc...

Atlanta, GARemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $110K *

Accelerate progress at pediatric mental health care by leading clinical quality assurance and supervision, mentoring clinicians, and providing evidence-based therapy to children and families in a full...

Pennsylvania, USRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$125K - $150K *

Empower operational excellence by developing and implementing technical training strategies across teams, ensuring compliance and effectiveness while enhancing workforce capabilities in high-stakes en...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$150K - $175K *

Elevate your career by leading a high-performing Security Engineering and CloudSecOps team. Drive security initiatives across cloud and enterprise environments, ensuring compliance and resilience whil...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$150K - $180K *

Empower growth by leading a dynamic sales organization, driving strategy, and optimizing performance. Oversee teams to achieve revenue goals, enhance productivity, and foster a high-performance cultur...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Staffing

$80K - $95K *

Help us manage diverse projects that drive strategic growth and collaboration across teams. As a key member of the EPMO, you'll ensure project success through effective stakeholder management and cont...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $205K *

Transform client relationships and drive growth by leading strategic initiatives in scientific visualization, medical education, and digital engagement. Manage multidisciplinary teams and oversee acco...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $175K *

Lead the charge in managing client-facing security operations, overseeing a high-performing team, and acting as a trusted advisor. Drive incident response, tool management, and process improvement to...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$160K - $200K *

Empower your career by leading health plan expansion efforts. Drive strategic partnerships, engage executives, and align teams to enhance our impact in the healthcare sector through innovative AI solu...

Austin, TXRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$74K - $98K *

Champion regulatory audit excellence by leading PACE audits, ensuring compliance, and driving cross-functional collaboration to enhance operational readiness and continuous improvement across the orga...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$210K - $250K *

Transform healthcare delivery by leading a team of Medical Directors and Clinical Directors, driving clinical strategy and performance excellence across portfolios while fostering relationships and in...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.