Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$134K - $230K *

Drive transformative AI initiatives across the enterprise, collaborating with executives and stakeholders to enhance efficiency and customer experiences while delivering measurable business value...

Minnetonka, MNRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$156K - $195K *

Champion the global eDiscovery Technology practice, leading a diverse team to innovate AI-assisted workflows, ensuring defensibility and quality across jurisdictions while driving growth and operation...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Legal & Accounting

$325K - $375K *

Drive revenue growth by leading a high-performing sales team in the Mid-Enterprise segment. Shape strategies for customer acquisition and market penetration while fostering relationships and collabora...

Philadelphia, PARemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$90K - $110K *

Champion coding excellence and risk adjustment initiatives while leading a dedicated team. Drive quality assurance, enhance provider documentation, and ensure compliance across multiple markets to opt...

Arizona, USRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$160K - $238K *

Build and scale the Partner Operations function, turning complexity into leverage by designing systems and processes that enhance partnerships and align with revenue goals for measurable impact and st...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$135K - $160K *

Pioneer in search strategy, driving optimization across paid, organic, and AI channels. This role collaborates with cross-functional teams to enhance visibility, engagement, and customer acquisition t...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $160K *

Drive operational excellence by leading a global team to deliver high-quality wellbeing programs. Collaborate with stakeholders to ensure effective execution, maintain standards, and enhance participa...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$177K - $295K *

Join us in leading strategic management of high-profile national health system accounts. Your expertise will drive long-term growth, customer satisfaction, and revenue targets while collaborating with...

RemoteRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$245K - $265K *

Build impactful partnerships with Medical Experts to enhance neurology care. Drive strategic insights and collaboration across teams, influencing marketing and education initiatives while engaging wit...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Join us to lead payer contracting strategies, negotiate complex agreements, and enhance reimbursement performance across diverse healthcare models while managing a high-performing team in a dynamic, r...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$125K - $150K *

Build high-performing software teams that drive critical project success while managing technical architecture and mentorship. Collaborate with leadership to align solutions with business needs and en...

Overland Park, KSRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $130K *

Champion innovative methodologies in medical communications, leading Delphi studies and expert panels. Drive strategic insights and deliver scientifically rigorous findings to support clinical develop...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$99K - $196K *

Lead and develop a team of Clinical Database Programmers to ensure timely, high-quality delivery of clinical database programming activities, driving operational excellence and innovation in clinical...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$182K - $216K *

Drive operational excellence by leading a 150+ member team, optimizing workflows, and enhancing member experiences through strategic program development and data-driven insights...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $105K *

Transform virtual resettlement services by leading a national portfolio that enhances access for refugees. Oversee strategy, implementation, and compliance while fostering partnerships and innovative...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Champion enterprise data architecture by establishing standards and a unified data catalog. Collaborate across teams to define metrics and ensure data governance, driving alignment and clarity in a ha...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$186K - $278K *

Lead strategic initiatives in healthcare economics, collaborating with national accounts to enhance patient outcomes and drive market access. Foster relationships with key stakeholders while executing...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$85K - $103K *

Join a team that's dedicated to enhancing strategic philanthropic partnerships, managing key relationships, and driving growth initiatives to achieve organizational goals while providing essential adm...

Brookline, MARemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $145K *

Innovate your career by leading retail operations across multiple banners, driving sales growth, enhancing customer experience, and optimizing operational efficiency through strategic leadership and t...

Quebec, CARemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$112K - $222K *

Lead clinical site management teams through project lifecycle, ensuring effective monitoring and communication. Drive project deliverables, budget management, and sponsor engagement to achieve impactf...

Durham, NCRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Join a team that's shaping global regulatory strategy for rare disease therapies. In this pivotal role, you'll lead submissions and agency interactions across the US, EU, UK, and Japan, driving execut...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Staffing

$100K - $120K *

Elevate operational excellence and quality management by leading process improvements, ensuring compliance, and fostering a patient-first culture. Oversee a dedicated team to enhance quality systems a...

Ontario, CARemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Shape the future of billing operations by leading a team to enhance accuracy, timeliness, and efficiency. Drive process improvements, manage complex accounts, and collaborate across functions to resol...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Support healthcare business development by engaging with executives, managing a multi-state territory, and driving client relationships. Utilize your sales expertise to strategize and grow our footpri...

Dallas, TXRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead the execution of complex client programs, ensuring timely delivery and budget adherence. Collaborate with cross-functional teams to drive accountability and clarity, while proactively managing ri...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.