Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$170K - $200K *

Unlock potential by providing strategic legal counsel on clinical and commercial operations, focusing on regulatory compliance, privacy, and data protection in a dynamic biopharmaceutical environment...

United StatesRemote

Reposted 2 days ago

  •   11 - 15 years exp.  •   Healthcare

$190K - $230K *

Join a team that's driving innovation in biopharma partnerships. Leverage your expertise to identify and advance strategic opportunities, influence cross-functional decisions, and manage alliances tha...

RemoteRemote

4 days ago

  •   8 - 10 years exp.  •   Business Services

$150K - $195K *

Lead the charge in shaping the U.S. HCP marketing strategy for JYNNEOS, driving integrated programs and optimizing engagement through data-driven insights and compliance, while collaborating across te...

Durham, NCRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $173K *

Join a team that's redefining AI-driven quality and performance operations. You'll build systems that enhance frontline team effectiveness and AI agent performance, ensuring impactful coaching and fee...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Transform corporate partnerships by building strong, lasting relationships. Drive revenue growth through strategic engagements and collaboration, connecting corporate interests with impactful mission...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $160K *

Elevate customer success by managing strategic enterprise accounts, driving value realization, and leading a growing team. Foster relationships across all levels, ensuring seamless renewals and expans...

New York, NYRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$115K - $158K *

Drive product ownership excellence by leading a team of Product Owners, prioritizing backlogs, and ensuring Agile practices are followed to maximize value delivery and meet business needs in a dynamic...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $201K *

Lead the charge in developing high-quality clinical and regulatory documents. Collaborate cross-functionally to ensure compliance and enhance clinical trial execution while mentoring a team of medical...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$202K - $250K *

Elevate the Personal Care department by driving strategic billing and claims initiatives, optimizing processes for accuracy and compliance, and leading a high-performing team to achieve operational ex...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Healthcare

$233K - $300K *

Drive excellence by leading global quality strategies, enhancing QA practices, and fostering innovation across diverse product teams. Collaborate with stakeholders to ensure high-performing, reliable...

RemoteRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Information Technology

$102K - $141K *

Join a team that's dedicated to enhancing sales performance through strategic process development, technology alignment, and targeted training. Collaborate with cross-functional teams to drive effecti...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$90K - $115K *

Empower a high-performing team to enhance customer trial experiences, driving strategic initiatives and fostering collaboration. Lead with data-driven insights to optimize processes and ensure excepti...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$125K - $150K *

Lead the Vendor Management Office, overseeing vendor governance, lifecycle management, and performance metrics. Collaborate cross-functionally to ensure vendor services align with quality, compliance...

CanadaRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$112K - $222K *

Empower the clinical site management team from initiation to closure, ensuring effective monitoring and sponsor engagement. Drive results while fostering a collaborative and professional environment...

Durham, NCRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $160K *

Drive strategic product planning and market intelligence to enhance physician engagement. Own product development and go-to-market strategies, ensuring alignment across teams to deliver innovative sol...

Newark, NJRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$54K - $159K *

Shape the future of healthcare by leading enterprise EHR policy development and workflow standardization. Collaborate across teams to enhance patient safety and operational efficiency while assessing...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Deliver strategic leadership for a centralized partner data management system, ensuring alignment with business priorities and enhancing user experience. Collaborate with cross-functional teams to dri...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$160K - $200K *

Transform the healthcare landscape by leading market entry and growth initiatives. Drive operational excellence and financial performance while building strategic partnerships to enhance patient acces...

West Palm Beach, FLRemote

Reposted today

  •   8 - 10 years exp.  •   Healthcare

$107K - $199K *

Transform the healthcare landscape by leading digital quality measurement initiatives. Drive process improvement efforts and enhance clinical data reporting strategies while collaborating with cross-f...

Missouri, USRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$242K - $303K *

Join as the primary privacy leader to manage and enhance an enterprise-wide privacy program while navigating complex regulations. Collaborate across departments to drive compliance, innovation, and ef...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $120K *

Drive operational excellence by leading global partnerships and enhancing efficiency. Collaborate with teams to achieve strategic goals, support change management, and ensure accountability in meeting...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Media

$80K - $120K *

Shape the future of Crop Protection & Chemicals by driving sales and fostering client relationships. Utilize strategic insights and collaboration to achieve targets and expand market presence while ma...

RemoteRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

$134K - $249K *

Drive your career forward by leading the development and implementation of strategic networking contracts. Oversee negotiations, manage team resources, and support market launches while enhancing heal...

Florida, USRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$299K - $369K *

Unlock your career potential by driving strategic medical partnerships with US health systems in oncology. Collaborate across functions to enhance evidence generation and meet healthcare priorities th...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$188K - $359K *

Lead pharmacy benefit management initiatives across diverse product lines, ensuring compliance and enhancing member access. Collaborate with cross-functional teams to optimize clinical outcomes and dr...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.