Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$110K - $130K *

Drive impactful clinical consulting by bridging expertise in real-world data with strategic insights. Collaborate across teams to enhance health outcomes research and contribute to thought leadership...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$237K - $296K *

Join a team that's driving innovation in oncology by leading clinical development and medical affairs. Collaborate across functions to advance pivotal programs and ensure operational excellence in a f...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Drive impactful change by optimizing product operations through collaborative process design, ensuring alignment and efficiency while fostering innovation and simplification across complex product tea...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Food & Beverages

$110K - $130K *

Transform talent acquisition by leading strategic initiatives that foster growth. Develop and optimize recruitment processes while creating a culture of inclusion and innovation to attract top talent...

Atlanta, GARemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$140K - $197K *

Lead the charge in managing strategic client relationships and projects, leveraging your extensive cost management expertise in the data centre sector. Empower teams through mentorship while driving b...

Birmingham, ALRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$176K - $294K *

Engage with healthcare professionals to deliver medical expertise and insights in oncology. Drive strategic initiatives, foster collaboration, and enhance patient-centric communications across diverse...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$162K - $292K *

Join a team that's redefining identity operations by leading a 24/7 team to enhance access management strategies. You'll shape the vision, drive process innovation, and foster talent in a collaborativ...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$225K - $275K *

Drive transformative healthcare consulting initiatives, leading engagement teams to enhance client outcomes through innovative strategies and strong leadership. Shape the future of patient experience...

Chicago, ILRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Business Services

$167K - $183K *

Lead the charge in optimizing G&A technology solutions, enhancing business processes through AI and automation. Collaborate with stakeholders to drive efficiency and compliance, ensuring scalable grow...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$112K - $193K *

Manage capital portfolio activities, driving strategy and benefit realization through collaboration with finance and technology leaders. Ensure investments are prioritized and governed, enhancing deci...

Eden Prairie, MNRemote

4 days ago

  •   5 - 7 years exp.  •   Healthcare

$181K - $225K *

Lead the charge in operationalizing complex clinical studies globally, collaborating with cross-functional teams to enhance proposal development and manage global lab relationships, ensuring strategic...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$181K - $225K *

Lead the charge in advancing scientific operations within a dynamic team, driving global lab relationships and supporting complex clinical studies. Collaborate across functions to ensure strategic, op...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$150K - $175K *

Join a team that's driving transformation in insurance technology by leading complex SaaS programs. You'll ensure delivery excellence, manage risks, and enhance client confidence while shaping the fut...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$134K - $184K *

Shape the future of customer success by leading a high-performing team, optimizing operations, and driving engagement and retention strategies to achieve key performance indicators and enhance client...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$195K - $244K *

Unlock your potential as a Global Regulatory Leader, driving regulatory strategy and submissions for CNS projects. Collaborate with cross-functional teams, mentor junior staff, and ensure compliance w...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$175K - $283K *

Champion regulatory excellence by leading CMC strategies for small molecule programs, ensuring compliance and driving successful submissions from early development through commercialization in a dynam...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$160K - $200K *

Champion enterprise-wide operational excellence by leading Central Operations, integrating reliability, training, and innovation to enhance performance, reduce risk, and drive measurable results acros...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$140K - $180K *

Shape the future of clinical quality assurance by overseeing trials, ensuring compliance with GCP and ICH standards, and driving operational excellence across clinical activities within a cross-functi...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$126K - $173K *

Champion the development of Provider Direct Connect capabilities, driving product vision and strategy while collaborating with cross-functional teams to enhance provider engagement and deliver scalabl...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$165K - $248K *

Drive growth by optimizing revenue operations, leading a high-impact team, and ensuring operational excellence across sales, marketing, and customer success, while leveraging advanced systems and data...

RemoteRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Legal & Accounting

$143K - $196K *

Elevate healthcare delivery by leading strategic partnerships and optimizing operations within Oncology service lines. Drive performance through exceptional customer engagement and collaboration acros...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$274K - $371K *

Develop and lead early phase clinical strategies for oncology candidates, ensuring design and execution of clinical trials. Collaborate with internal teams and external experts to drive innovative dru...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $100K *

Join a dynamic team to drive the implementation of innovative service lines, enhancing clinician and patient experiences. Collaborate cross-functionally to optimize operations and lead initiatives tha...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$270K - $295K *

Join a team that's dedicated to advancing the Medical Information function for product launches and growth. Lead strategy, vendor partnerships, and scientific content development while ensuring compli...

Houston, TXRemote

4 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Unlock potential by delivering expert medical information support to healthcare professionals, ensuring safe product use through timely, evidence-based responses and effective communication across mul...

Overland Park, KSRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.