Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$285K - $325K *

Drive transformational patient impact by leading cross-functional teams and executing strategic drug development programs in an agile environment. Foster collaboration and accountability to deliver in...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$187K - $210K *

Champion operational excellence by leading Product Operations, driving innovation, and optimizing workflows. Manage a dedicated team to enhance product delivery, streamline processes, and ensure align...

Austin, TXRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$195K - $245K *

Champion AI strategy and implementation in healthcare, leading a team to deliver measurable value. Drive business development, client engagement, and practice growth while shaping innovative solutions...

Chicago, ILRemote

1 week ago

  •   8 - 10 years exp.  •   Business Services

$110K - $130K *

Empower healthcare IT delivery by managing a dynamic team, ensuring operational excellence, and driving EMR performance. Collaborate with clinical stakeholders to enhance patient care through effectiv...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$122K - $158K *

Join a team that's dedicated to operational excellence in pharmacy care. Lead clinical operations, enhance patient experiences, and foster a culture of continuous improvement while ensuring compliance...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$186K - $233K *

Shape impactful marketing strategies for lung cancer programs, collaborating with cross-functional teams to drive patient engagement and launch readiness. Lead initiatives that align with brand goals...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$156K - $195K *

Own the end-to-end B2B2C enrollment funnel by transforming data into actionable insights, optimizing processes, and leading cross-functional collaboration to enhance growth and ensure successful membe...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$205K - $265K *

Empower your career by optimizing sales operations and driving efficiency. Collaborate with cross-functional teams to enhance processes, manage forecasts, and implement strategic initiatives that supp...

Atlanta, GARemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$125K - $300K *

Champion strategic growth by partnering with executive leadership to drive operational excellence, enhance data integrity, and lead cross-functional initiatives that propel business expansion and prod...

Boston, MARemote

6 days ago

  •   8 - 10 years exp.  •   Consumer Technology

$148K - $175K *

Lead strategic initiatives and operational excellence across client portfolios, ensuring governance, performance management, and continuous improvement. Drive client satisfaction and financial account...

Chicago, ILRemote

1 week ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$272K - $340K *

Join a team that's driving CMC strategy and execution for innovative therapies. Lead cross-functional efforts in drug and device development, ensuring compliance and operational excellence from clinic...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Shape the future of enterprise-scale cybersecurity by leading vulnerability management initiatives. Drive program strategy, enhance client relationships, and mentor teams to achieve measurable risk re...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Champion enterprise-scale delivery by leading vulnerability management initiatives, driving program strategy, and fostering client relationships to achieve measurable risk reduction across diverse tec...

New York, NYRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$274K - $371K *

Lead the early phase clinical development of innovative therapeutics, collaborating across teams to design and execute trials. Your expertise will directly influence strategy, protocol development, an...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$190K - $210K *

Collaborate with cross-functional teams to drive clinical biomarker strategy and execution, translating discovery insights into actionable approaches that enhance patient outcomes in early neuroscienc...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$135K - $180K *

Transform healthcare sales by building strategic relationships within managed care organizations. Drive revenue growth through effective selling and relationship management while maximizing exposure t...

Georgia, USRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Lead complex healthcare project initiatives, ensuring successful implementation and operational readiness while maintaining high standards of governance. Foster strong partnerships with clients, manag...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$115K - $140K *

Drive operational excellence in commercial readiness and support cross-functional teams to ensure effective execution of launch strategies and operational priorities in a dynamic biotech environment...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$172K - $223K *

Champion operational excellence as a strategic leader, driving performance and financial results across the PacWest Region while ensuring safety, quality, and compliance in a mission-driven environmen...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$175K - $245K *

Lead the strategic publication function for BHB-1893, driving evidence generation and dissemination in hypertrophic cardiomyopathy. Collaborate cross-functionally to ensure timely, high-quality public...

San Francisco, CARemote

5 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$101K - $142K *

Transform compensation consulting by developing and administering programs, analyzing market data, and providing expert guidance to clients, all while ensuring project deliverables are met in this dyn...

Ohio, USRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$126K - $191K *

Lead the charge in implementing an integrated risk framework across the enterprise, enhancing resilience and oversight while guiding teams in risk management, business continuity, and crisis response...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $232K *

Unlock potential by leading legal reviews for promotional and medical materials. Collaborate across teams to ensure compliance and provide practical guidance in a fast-paced environment, supporting pr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$176K - $287K *

Contribute to companion diagnostic strategy and development, leading programs from biomarker feasibility to clinical validation. Collaborate across teams to ensure diagnostics align with therapeutic m...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$185K - $210K *

Engage with clients to drive retention and growth strategies, fostering deep relationships and collaboration across teams. Leverage market insights to enhance product offerings and ensure client succe...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.