Director, Clinical Operations Jobs

Explore Director, Clinical Operations opportunities for experienced leaders who guide the planning and delivery of clinical research. These roles oversee teams, processes, budgets, and vendor relationships to help clinical trials run efficiently while meeting quality, regulatory, and business goals. Ladders features vetted professional jobs with salaries of $100,000 or more.

What Does a Director of Clinical Operations Do?

Directors of Clinical Operations shape operational strategy across clinical programs and studies. They may lead study planning and execution, manage clinical operations teams, monitor timelines and budgets, oversee CRO and site partnerships, and establish processes for consistent trial delivery. The scope varies by employer, therapeutic area, and organization size.

Qualifications and Skills

Employers commonly seek substantial clinical research experience, a record of leading teams or complex studies, and a strong understanding of clinical trial operations and applicable regulations. Relevant strengths can include project and portfolio management, budget oversight, risk assessment, vendor management, communication, and the ability to collaborate across clinical, medical, regulatory, data, and quality teams. Requirements differ by role; some positions prefer an advanced degree or therapeutic-area expertise.

Career Opportunities and Work Settings

Director-level clinical operations professionals work at biotechnology and pharmaceutical companies, contract research organizations, medical device firms, and other research organizations. Depending on the role, responsibilities may span a single study, a regional team, or a broad clinical development portfolio. Search current openings to compare leadership scope, work arrangements, and employer needs.

Find Director, Clinical Operations Jobs on Ladders

Use Ladders to discover vetted Director, Clinical Operations jobs paying $100,000 or more. Review role requirements and compensation details, then identify opportunities aligned with your clinical research leadership experience and career goals.

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$110K - $130K *

Join a team that's dedicated to optimizing healthcare delivery through strategic leadership in Utilization Management. Drive excellence in clinical care and operational outcomes while ensuring complia...

Englewood, CORemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$210K - $250K *

Drive impactful clinical trials by providing medical oversight and ensuring compliance with regulations. Collaborate with teams to manage safety profiles and support business development, enhancing dr...

Philadelphia, PARemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Join a team that's advancing oncology solutions by managing global clinical trials. Lead project execution from protocol development to study closeout, ensuring quality and compliance while fostering...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $90K *

Champion project success by managing timelines, resources, and stakeholder communication. Drive seamless implementation experiences while collaborating with cross-functional teams to deliver value-dri...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$152K - $254K *

Shape the future of behavioral health by leading clinical programs, driving strategic initiatives, and fostering cross-functional partnerships to enhance member outcomes and operational excellence...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Healthcare

$149K - $224K *

Lead the charge in transforming healthcare solutions by overseeing the entire implementation lifecycle, ensuring quality standards, and driving customer adoption through effective education and suppor...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$210K - $250K *

Help us redefine clinical trial safety by managing comprehensive drug development processes. Collaborate with multidisciplinary teams to ensure adherence to standards, provide medical consultation, an...

Texas, USRemote

Reposted 1 month ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$85K - $100K *

Empower your career by leading a clinic with ownership potential. Drive growth, manage operations, and ensure exceptional patient care while benefiting from the support of an established organization...

Illinois, USRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Engage in pivotal regulatory activities and drive compliance strategies supporting late-stage clinical development. Collaborate with cross-functional teams to ensure high-quality submissions and navig...

New York, NYRemote

4 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$108K - $130K *

Drive program delivery across multiple products, ensuring timely outcomes by managing risks, dependencies, and stakeholder priorities. Collaborate cross-functionally to maintain accurate project data...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$200K - $250K *

Champion growth strategies across HHS, leveraging deep market knowledge and relationships to drive business development, capture, and delivery in a dynamic federal health environment...

Washington, DCRemote

3 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$157K - $262K *

Drive enterprise vendor management strategy by overseeing vendor relationships, governance, and performance. Collaborate with cross-functional teams to ensure compliance, optimize costs, and enhance o...

California, USRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Accelerate program implementation and stakeholder engagement in pharmaceutical market access. Oversee daily operations, client relations, and staff management while ensuring adherence to budgets and p...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$180K - $220K *

Drive clinical excellence by providing medical expertise across therapeutic areas, ensuring safety and integrity in clinical trials. Collaborate with project teams and senior management to enhance cli...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Drive the planning and execution of complex therapeutic programs from discovery to clinic. Serve as a senior program management partner, ensuring successful execution and alignment across cross-functi...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Drive your career with a leadership role overseeing marketing operations, guiding teams to enhance sales processes, optimize technology strategies, and deliver impactful data analysis for informed dec...

United StatesRemote

Reposted 4 days ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Unlock potential by driving product strategy and enhancements for healthcare ambulatory software. Lead cross-functional teams to deliver impactful features, manage product lifecycles, and ensure align...

Georgia, USRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$150K - $235K *

Join a team that's redefining business processes through digital transformation. Lead cross-functional initiatives, ensuring scalable and standardized practices that align with strategic goals while f...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$177K - $278K *

Partner with us to drive the strategic vision and operational excellence of our Veeva Regulatory Information Management platform, ensuring compliance and enhancing global regulatory processes through...

Massachusetts, USRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$263K - $325K *

Advance your career by building and leading the pharmacovigilance function from the ground up. In this pivotal role, you'll oversee drug safety operations, collaborate with cross-functional teams, and...

United StatesRemote

Reposted 6 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$246K - $332K *

Drive pediatric development strategy by integrating clinical insights and regulatory commitments across multiple therapeutic areas, ensuring effective execution from candidate transition to post-marke...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Join a dynamic team focused on delivering exceptional solutions and driving results. This role requires effective communication and collaboration to tackle challenges and enhance operations within a p...

Georgia, USRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$185K - $225K *

Accelerate your career by leading revenue cycle improvements for healthcare organizations. Drive compliance, enhance financial performance, and foster collaborative teams to achieve impactful client o...

Chicago, ILRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$100K - $125K *

Manage a team of medical writers to develop impactful scientific content, ensuring accuracy and compliance. Collaborate with clients and cross-functional teams to drive medical strategies and delivera...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Shape innovative solutions by leveraging your expertise in a dynamic office environment. Collaborate with cross-functional teams and contribute to project success while ensuring high standards of accu...

North Carolina, USRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

Frequently Asked Questions (FAQ)

  • What does a Director of Clinical Operations do?question toggle

    A Director of Clinical Operations leads the planning and execution of clinical research operations. Responsibilities may include managing teams, study timelines and budgets, site and vendor relationships, operational processes, and compliance with applicable requirements.

  • What qualifications are typically required for Director, Clinical Operations jobs?question toggle

    Employers generally look for significant clinical research experience and demonstrated leadership in clinical trial operations. Knowledge of trial regulations, project management, budgeting, vendor oversight, and cross-functional collaboration is often valuable. Specific education and experience requirements vary.

  • Where do Directors of Clinical Operations work?question toggle

    They may work for pharmaceutical and biotechnology companies, contract research organizations, medical device firms, and other organizations conducting clinical research.

  • How much do Director, Clinical Operations jobs pay?question toggle

    Compensation varies by employer, location, experience, and role scope. Ladders focuses on vetted professional opportunities paying $100,000 or more; check each listing for its stated compensation and details.

  • How can I find Director, Clinical Operations jobs?question toggle

    Browse current listings on Ladders and compare job responsibilities, qualifications, work arrangements, and compensation to find roles that match your experience and career goals.