Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$115K - $158K *
Join us to shape the future of member experiences in healthcare by leading innovative design projects, collaborating with cross-functional teams, and enhancing service delivery through user-centered d...
2 days ago
$58K - $105K *
Unlock your potential by managing the full contracting lifecycle, supporting critical agreements for Medicare Advantage and Commercial operations, while collaborating with diverse teams to enhance com...
3 days ago
Counsel - Commercial Transactions
$132K - $221K *
Drive enterprise-wide legal support for global contracting activities, focusing on procurement and technology transactions. Collaborate with cross-functional teams to manage risks and ensure complianc...
2 weeks ago
Director, Chronic Practice Liaison - Remote
$126K - $210K *
Lead strategic initiatives to enhance referral growth and provider engagement across chronic therapy markets. Drive collaboration among cross-functional teams to optimize patient progression and deliv...
3 weeks ago
Senior Scientific Director (Rare/Neurology/Psychiatry)
$150K - $180K *
Lead the charge in developing and overseeing scientific content across multiple therapeutic areas, ensuring high-quality contributions and strategic client interactions to drive growth and innovation...
4 weeks ago
$68K - $105K *
Help us lead enterprise-wide incident responses and internal investigations into misconduct, ensuring compliance and effective fraud detection while collaborating across departments to uphold organiza...
Reposted today
$110K - $130K *
Drive the success of Abacum implementation projects, managing end-to-end delivery while collaborating with sales and partners to ensure client satisfaction and value realization on the platform...
2 weeks ago
$150K - $180K *
Elevate data privacy standards by leading a comprehensive privacy program. Collaborate across teams to integrate privacy-by-design principles, enhance data governance, and ensure compliance while enab...
2 weeks ago
Vice President, Clinical Operations
$200K - $250K *
Make your mark at the forefront of clinical operations, driving global studies from strategy to execution while ensuring operational integration across teams and vendors for successful Phase 3 program...
1 month ago
Physician, Internal Medicine - Telemedicine Opportunity - DrHouse
$210K *
Join a dynamic telemedicine team to deliver high-quality, patient-centered care across South Dakota. Enjoy flexible scheduling while managing diverse clinical cases, including primary and urgent care...
1 week ago
$90K - $110K *
Drive growth in digital therapeutics by engaging medical practices, guiding them from initial interest to consistent orders. Collaborate with sales and clinical teams to shape the onboarding process a...
6 days ago
$99K - $136K *
Transform supplier relationships and drive category growth through strategic marketing, sales analysis, and new product launches. Lead initiatives to enhance profitability and market share while colla...
3 weeks ago
Analyst, Privacy (Privacy Assessments)
$135K - $159K *
Drive privacy excellence by executing assessments and managing risks across products. Collaborate with Legal, Product, and Engineering to embed privacy by design and enhance frameworks that protect cu...
6 days ago
Corporate Charge Capture Auditor, Outpatient
$63K - $101K *
Optimize compliance in Interventional Radiology charge capture by conducting audits, educating teams, and enhancing coding practices. Collaborate with clinical departments to identify and rectify codi...
3 weeks ago
Staff Engineer, Detection and Response
$225K - $281K *
Lead the charge in shaping detection and response strategies, driving hands-on initiatives to enhance security architecture and incident management. Collaborate across teams to ensure robust threat de...
1 week ago
Senior Medical Stop Loss Underwriter
$79K - $127K *
Empower your career by analyzing contracts and pricing strategies to optimize profitability and growth. Utilize your underwriting expertise to assess risks, support internal initiatives, and guide tea...
2 weeks ago
$71K - $118K *
Engage in advanced nuclear imaging procedures, ensuring patient safety and quality care. Collaborate with a skilled team using state-of-the-art technology to deliver diagnostic and therapeutic service...
Reposted 2 weeks ago
$68K - $105K *
Champion the implementation and support of Epic Beaker applications, ensuring effective system design, user experience, and problem resolution while managing projects and enhancing end-user engagement...
3 weeks ago
Healthcare Payment Solutions Consultant - Enterprise Market
$126K - $154K *
Transform healthcare payment solutions by driving business growth and optimizing client relationships. Leverage your expertise to develop tailored proposals and secure long-term partnerships with larg...
1 week ago
$142K - $168K *
Transform client experiences by leveraging deep expertise in healthcare solutions. Lead strategic initiatives, enhance client relationships, and drive impactful outcomes for high-value accounts throug...
1 week ago
Account Specialist (Roseville, CA)
$160K - $192K *
Accelerate progress at driving commercial performance by engaging healthcare providers, building relationships, and supporting product launches to ensure patient access to innovative therapies across...
1 week ago
Director of Clinical Strategy - Compliance Suite (ControlCheck & PrivacyPro)
$130K - $150K *
Shape the future of healthcare technology by leading clinical strategy initiatives to enhance drug diversion prevention and ensure patient privacy compliance. Drive impactful relationships, educate st...
Reposted 2 weeks ago
$125K - $150K *
Elevate client relationships as a strategic leader, driving retention and growth. Collaborate with cross-functional teams to deliver exceptional service and develop high-performing teams focused on cl...
3 weeks ago
Physician - Emergency Medicine
$210K - $250K *
Shape the future of emergency care by providing critical healthcare services in a dynamic environment. Collaborate with a multidisciplinary team to treat diverse patient needs, ensuring high-quality c...
3 weeks ago
Associate Medical Director (RadScience)
$110K - $130K *
Join a dynamic team to lead the creation of impactful scientific content, enhancing medical education and patient outcomes. Collaborate cross-functionally, mentor writers, and drive excellence in heal...
1 week ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.