Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Dentist Jobs in South Dakota

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$200K - $300K *

Pioneer partner success by leading technical enablement for contact center solutions. Drive onboarding, co-selling support, and strategic architecture using Zendesk and AWS technologies to empower par...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$159K - $215K *

Join a team that's driving operational excellence across 25+ sites, overseeing facilities, real estate, and security operations to ensure safe, efficient environments that support high-quality care de...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$245K - $265K *

Shape the future of neurology by building partnerships with Medical Experts, driving insights, and collaborating across teams to enhance patient care and strategic initiatives in a dynamic healthcare...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$129K - $231K *

Reimagine drug discovery as you lead molecular pharmacology efforts in neuroscience. Collaborate across teams to develop strategies, interpret data, and advance innovative therapies for sleep-wake dis...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$82K - $90K *

Empower successful RHTP initiatives through stakeholder engagement, communications, and project support. Collaborate with diverse teams to ensure effective outreach, timely execution, and inclusive pa...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$150K - $180K *

Drive transformative AI initiatives across departments by leading a strategic team in designing scalable, agentic workflows that enhance decision-making and efficiency, ensuring measurable business ou...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $160K *

Engineer resilient backend solutions for privileged account discovery, enhancing security while navigating complex, customer-deployed environments. Collaborate on data-processing workflows using cutti...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $120K *

Partner with us to drive marketplace performance in optometry practices. You'll activate, train, and support teams, ensuring our digital platform integrates seamlessly into daily workflows while boost...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$151K - $207K *

Unlock potential by driving strategic growth in healthcare sales, fostering executive relationships, and leading cross-functional teams to achieve commercial targets across Siemens Healthineers' Imagi...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by leading the full sales cycle, building executive relationships, and driving business transformation across industries. Collaborate with teams to innovate sales processes and ensure...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $95K *

Unlock potential by designing innovative digital experiences that inspire and engage. Collaborate with teams to create user-centered solutions, leveraging research and creativity to tackle complex cha...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$77K - $85K *

Join a dedicated team to enhance clients' independence and quality of life through tailored occupational therapy interventions. Collaborate in a supportive environment, focusing on daily living skills...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$180K - $200K *

Reimagine security engineering leadership by guiding strategic initiatives across cloud and infrastructure security, enhancing detection engineering, and fostering collaboration to protect a multi-clo...

RemoteRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$93K - $140K *

Elevate cloud security by enhancing standards and implementing risk-based controls across Azure and AWS. Collaborate with teams to secure applications and support AI initiatives, ensuring robust gover...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Elevate sales performance by developing and scaling a forward-thinking sales enablement strategy. Lead onboarding, ongoing skills enhancement, and sales methodology adherence while leveraging AI-drive...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$203K - $304K *

Champion innovative operational strategies in clinical research, driving excellence in bid defense meetings and proposal development. Collaborate with cross-functional teams to enhance study execution...

United StatesRemote

2 weeks ago

  •   15+ years exp.  •   Healthcare

$110K - $115K *

Join a team that's redefining healthcare project management. Lead integrated initiatives, mentor talent, and drive excellence across diverse campaigns while fostering collaboration and innovation in a...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$143K - $183K *

Shape the future of security testing by identifying vulnerabilities in AI-driven systems. Collaborate with engineers to enhance security protocols and tools, ensuring robust protection for innovative...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Elevate patient care by delivering virtual health services, ensuring compliance with regulations, and fostering teamwork in a dynamic environment. Utilize your expertise to provide accurate diagnoses...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$140K - $180K *

Champion innovation by developing full-stack web applications using TypeScript. Collaborate in a dynamic, remote-first team to deliver engaging user experiences, streamline operations, and lead techni...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$90K - $110K *

Elevate your career by managing a diverse portfolio of retail and industrial properties across multiple states. This hands-on role focuses on operational excellence, financial performance, and tenant...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$175K - $231K *

Lead the charge in managing procurement operations for critical infrastructure projects. Collaborate with project teams to ensure compliance, negotiate contracts, and drive supplier relationships, con...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$100K - $120K *

Lead client engagement and implementation strategies to drive adoption and maximize value from Managed Services. Foster partnerships, optimize workflows, and ensure long-term client success through ef...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$163K - $204K *

Unlock potential by leading innovative machine learning methods for cancer detection, collaborating with experts, and mentoring junior scientists to advance research in multi-cancer early detection us...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Lead the charge in enhancing partnerships within our Collaborative Care Program, focusing on driving referral growth and provider satisfaction through strategic engagement and support at various accou...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.