Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Dentist Jobs in South Dakota

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$125K - $150K *

Accelerate growth in the enterprise market by driving sales and relationships. Collaborate with cross-functional teams to penetrate large accounts, manage complex negotiations, and shape go-to-market...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$170K - $185K *

Champion innovative software solutions by leading complex projects, mentoring engineers, and driving technical excellence across teams. Collaborate on strategic initiatives to enhance reliability and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $190K *

Shape the future of client engagements by leading procurement relations, fostering trust, and unlocking growth opportunities through strategic partnerships that enhance collaboration and drive expansi...

RemoteRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$220K - $240K *

Optimize customer success through strategic leadership and analytics, guiding a global team to deliver exceptional customer experiences and drive market growth in the Resins & Technologies sector...

RemoteRemote

1 month ago

  •   8 - 10 years exp.  •   Business Services

$110K - $130K *

Unlock potential by driving territory growth through strategic sales and account management. Collaborate with healthcare professionals to enhance customer experience and position as a leader in tumor...

South Dakota, USRemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Champion sustainability initiatives by leading client portfolios, managing projects, and enhancing service offerings. Collaborate with teams to deliver impactful solutions and drive strategic growth i...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$110K - $130K *

Empower cross-functional teams to innovate and enhance platform capabilities, ensuring alignment with client needs and regulatory standards. Drive product vision from inception to adoption, leveraging...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$209K - $238K *

Transform the digital landscape by architecting high-performance front-end solutions. Collaborate with cross-functional teams to enhance user experience and drive SEO strategies, impacting millions of...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$193K - $256K *

Transform client success by leading a large team to enhance service delivery, drive strategic initiatives, and leverage technology for improved client outcomes across diverse segments in a dynamic env...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Healthcare

$143K - $200K *

Innovate solutions as a Senior Appian Developer, tackling complex BPM challenges. Collaborate with teams to design, implement, and optimize high-performance applications while mentoring junior develop...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$72K - $107K *

Join a team that's dedicated to enhancing resident development through effective program management, collaboration with clinical leaders, and innovative professional development sessions to ensure a s...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$107K - $199K *

Redefine pharmacy care by developing formularies and policies, enhancing quality programs, and driving initiatives that improve Medicaid services while collaborating with diverse teams and stakeholder...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$194K - $270K *

Shape the future of our strategic initiatives by leading high-impact projects that drive innovation and collaboration across teams. Partner closely with executive leadership to deliver measurable resu...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$131K - $190K *

Lead strategic initiatives that enhance customer engagement and drive actionable insights. Collaborate cross-functionally to improve processes, connect feedback to decisions, and advance customer expe...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$74K - $130K *

Drive procurement excellence by managing software assets, contracts, and vendor relationships. Collaborate with teams to ensure efficient workflows and budget management while enhancing procurement pr...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $95K *

Drive compliance excellence by overseeing complex insurance activities, ensuring adherence to investor and regulatory standards while mentoring junior team members and enhancing operational processes...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$211K - $281K *

Champion regulatory excellence by leading U.S. FDA engagement and strategy for product development, ensuring timely approvals and compliance while driving cross-functional collaboration and organizati...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Drive strategic growth as you build relationships with C-level executives, lead complex sales cycles, and exceed quotas in selling enterprise-level SaaS solutions to $20bn+ clients while managing a de...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Tackle data-driven decisions as a senior product analyst, owning A/B testing design and analysis while collaborating across teams to enhance user experience and drive growth through insightful experim...

RemoteRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$120K - $162K *

Drive pharmacy operations as a licensed Pharmacist, ensuring compliance, safety, and exceptional customer care. Lead a dedicated team while managing workflow, performance metrics, and process improvem...

United StatesRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$150K - $180K *

Unlock potential by leading a dynamic team in Workforce Management and Quality Assurance. Drive operational excellence, vendor partnerships, and innovative strategies to enhance service delivery and p...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Transform your career by driving new revenue growth in diverse industries. As a key sales leader, you'll identify prospects, develop relationships, and deliver tailored marketing solutions, ensuring c...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Media

$136K - $170K *

Partner with us to enhance patient access by leading market access strategies, educating teams, and collaborating across departments to ensure effective reimbursement for our innovative medical techno...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Tackle new business acquisition by executing strategic sales processes to foster relationships and drive revenue growth in the healthcare IT sector. Collaborate cross-functionally while presenting sol...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Join us to lead and enhance our Environmental, Health, and Safety initiatives, ensuring compliance and fostering a culture of safety and environmental stewardship across all levels of the organization...

3 weeks ago

  •   5 - 7 years exp.  •   Food & Beverages

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.