Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Dentist Jobs in South Dakota

Sort By: Relevance

$96K - $120K *

Partner with cross-functional teams to drive successful integrations, ensuring best practices and client satisfaction. Become the internal expert on data management while leading technical relationshi...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$145K - $220K *

Drive impactful product marketing strategies for proactive security solutions, guiding market positioning, launches, and customer engagement. Collaborate with cross-functional teams to shape product d...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Empower the execution of CMC strategies by collaborating across teams to enhance production, streamline operations, and drive commercial success for innovative therapeutics and diagnostics, ensuring a...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$74K - $119K *

Transform healthcare delivery by coordinating strategic programs that enhance clinical and operational excellence. Collaborate with diverse teams to implement innovative solutions, ensuring compliance...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$160K - $180K *

Champion growth and satisfaction by managing key Ecosystem client relationships. Drive sales of innovative data solutions in Life Sciences, leveraging deep industry knowledge to meet client needs and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$119K - $221K *

Support dynamic legal processes in tech sales by negotiating complex agreements. Collaborate with cross-functional teams, manage high volumes of transactions, and drive legal department initiatives wh...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Consumer Technology

$89K - $170K *

Pioneer innovative software solutions by developing and maintaining high-quality applications. Collaborate within a cross-functional team to enhance system performance and reliability, ensuring except...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

$190K *

Reimagine consumer experiences by leading product strategy and technology development for digital platforms. Drive innovation and enhance customer engagement through seamless interactions and data-dri...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Advance client relationships and team performance as a strategic leader, overseeing captive insurance operations, driving excellence, and enhancing service delivery while managing complex engagements...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $157K *

Shape the future of commercial banking by leading strategic implementations, optimizing client operations, and advising on best practices to enhance financial institution capabilities and drive long-t...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Transform the insurance appeals process by managing, researching, and drafting compliant responses to billing deductions. Collaborate with legal teams to enhance efficiency and build strong relationsh...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$150K - $160K *

Lead the charge in executing population health strategies, ensuring high-quality consulting delivery and team performance across regions. Collaborate with leadership to drive impactful solutions and f...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$176K - $243K *

Unlock potential by driving the adoption of advanced electrophysiology solutions through strategic partnerships, enhancing customer engagement, and fostering relationships with key stakeholders to ens...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$70K - $120K *

Lead transformative Medicaid initiatives by guiding project oversight, ensuring timely execution, and enhancing stakeholder engagement. Collaborate with teams to streamline operations and achieve stra...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$128K - $170K *

Optimize financial strategies and drive growth initiatives as a trusted advisor to leadership. Engage in M&A analysis, pricing strategy, and market insights to enhance decision-making in a dynamic Saa...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $250K *

Join a team that's shaping growth strategies for Federal Civilian accounts. Leverage your expertise in federal markets to drive business development, capture opportunities, and enhance customer relati...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$165K - $175K *

Empower progress at the forefront of data product management, leading the development of innovative solutions. Drive product success through strategic oversight, client engagement, and cross-functiona...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $192K *

Join a team that's pivotal in driving commercial performance and product adoption. Engage healthcare providers, build relationships, and support innovative therapies while collaborating with cross-fun...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$83K - $110K *

Lead operational excellence by managing complex training programs and enhancing processes for a statewide initiative, ensuring effective communication and client engagement while fostering a high-perf...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Lead a dynamic team in managing compliance and risk within the mortgage sector. Ensure timely review of disposition requests and foster adherence to ECOA, FCRA, and adverse action regulations while dr...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$166K - $192K *

Elevate user experience by leading end-to-end product design, driving stakeholder alignment, and optimizing complex workflows. Utilize your expertise to deliver impactful, user-centered solutions in a...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Hospitality & Recreation

$90K - $100K *

Join a team that's passionate about transforming complex scientific data into engaging communications. Collaborate with cross-functional experts to deliver high-quality medical content and strategies...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Engage with clients to showcase innovative healthcare solutions, driving sales success through impactful demonstrations and expert guidance. Collaborate with sales teams to address client needs and en...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$105K - $130K *

Join a team that's driving innovation in Oracle Cloud Financials. Collaborate with clients and technical teams to design solutions, execute configurations, and support end-users, all while enhancing y...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$244K - $279K *

Unlock potential by leading innovative solutions in cloud banking. Collaborate with experts to drive modernization, mentor peers, and optimize technology strategies across multiple projects, ensuring...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.