Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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Dentist Jobs in South Dakota

Sort By: Relevance

$187K - $234K *

Join a team that's dedicated to ensuring the safety and effectiveness of cancer treatments. Utilize your expertise in medical physics to conduct quality assurance, develop clinical protocols, and supp...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Lead the future of patient experience by driving strategic initiatives and operational excellence in a high-volume healthcare contact center. Collaborate with cross-functional teams to enhance service...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$230K - $250K *

Lead the charge in shaping a premium brand vision while driving creative strategy and operational excellence in a high-growth environment. Collaborate with cross-functional teams to elevate brand iden...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Join a dynamic team to design and develop innovative mobile solutions across Android and iOS. Take ownership of projects, collaborate with peers, and contribute to the broader tech stack while enhanci...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Legal & Accounting

$150K - $180K *

Transform your career by leading AI initiatives that drive business growth and operational efficiency. Collaborate across functions to embed AI into Rho's core operations, shaping a future where AI en...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$180K - $215K *

Lead the charge in driving regional sales success through strategic execution, team leadership, and cross-functional collaboration. Foster strong customer relationships and ensure alignment with corpo...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Engage with key healthcare clients to drive strategic account management, fostering relationships and delivering tailored solutions across GE HealthCare’s diverse portfolio, while leading cross-functi...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$210K - $230K *

Accelerate progress at the forefront of clinical supply chain management, leading strategic initiatives to ensure seamless delivery of investigational products for global trials while collaborating ac...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Partner with us to drive transformative healthcare solutions by managing key accounts, fostering relationships, and ensuring measurable outcomes. Your expertise will enhance provider partnerships and...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $110K *

Innovate data solutions by developing complex reports and analyses to support senior management and client needs. Collaborate with teams to enhance data literacy and provide technical guidance across...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$123K - $157K *

Lead the charge in global sourcing strategies for plastics, driving supplier relationships and cost optimization while ensuring supply continuity and supporting new product introductions across manufa...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$180K - $220K *

Unlock your potential by driving enterprise growth in healthcare. Join a dynamic team focused on building relationships with health systems and provider organizations, leveraging a robust support engi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$86K - $138K *

Lead the charge in defining and executing a comprehensive product strategy, driving value across product portfolios. Collaborate with key stakeholders to align strategic vision while overseeing perfor...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$135K - $160K *

Lead the strategic design and management of comprehensive benefits programs, ensuring alignment with employee needs and company objectives. Drive innovation and compliance while enhancing employee eng...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$73K - $108K *

Manage and deliver comprehensive physical therapy programs for diverse clients, conducting evaluations and interventions to enhance mobility, relieve pain, and improve strength. Collaborate with healt...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$72K - $116K *

Unlock potential as a mid-level actuarial analyst, applying statistical techniques to enhance insurance pricing, claims analysis, and profitability studies while progressing through the Actuarial Exec...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$245K *

Partner with us to redefine virtual primary care, delivering exceptional patient services through innovative telehealth solutions. Join our dedicated team to enhance health accessibility and effective...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$200K - $245K *

Join a team that's dedicated to providing expert employment counsel across a global workforce. You'll partner with business leaders to navigate complex employment issues, ensuring sound legal advice t...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Accelerate growth by coaching franchise owners in sales strategies, optimizing processes, and enhancing customer acquisition. Collaborate cross-functionally to develop training programs that foster a...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Staffing

$110K - $125K *

Elevate healthcare operations by leading credentialing and medical staff services across multiple states. Drive compliance, streamline onboarding, and enhance workflows to support over 200 professiona...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $90K *

Lead the charge in driving sales growth by engaging independent physician practices. Utilize your expertise in full-cycle sales to build relationships, conduct virtual demos, and collaborate with team...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$86K - $138K *

Lead the charge in defining product vision and strategy, aligning stakeholders, and overseeing execution. Collaborate across teams to prioritize clinical data assets, ensuring maximum business value a...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$250K - $300K *

Champion strategic growth by leading the charge to secure complex health system accounts. Drive transformative deals with hands-on coaching, leveraging deep relationships and expertise to elevate team...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$107K - $180K *

Join a team that's redefining API integration! Leverage your technical expertise to guide partners through the integration lifecycle, ensuring seamless onboarding and successful implementations while...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Media

$95K - $130K *

Lead the charge in backlog management and agile ceremonies, translating stakeholder needs into prioritized tasks. Collaborate across squads to ensure delivery quality and stakeholder satisfaction whil...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.