Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
1,000+

Dentist Jobs in South Dakota

Sort By: Relevance

$95K - $124K *

Transform corporate legal operations by managing due diligence, governance, and vendor relationships. Collaborate across teams to ensure compliance and streamline processes, while supporting attorneys...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $140K *

Lead the charge in delivering innovative healthcare solutions by engaging with clients, understanding their needs, and providing technical guidance throughout the sales process to drive successful out...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $200K *

Accelerate progress at the forefront of product innovation, leading a team to drive strategy and customer experience for a key transaction management platform while embedding AI to enhance efficiency...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$114K - $167K *

Engineer innovative ERP solutions by analyzing complex business processes, defining architecture, and leading integration efforts to optimize performance and ensure compliance. Drive impactful customi...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $140K *

Play a key role in leading complex analytical projects, driving Federal transformation engagements, and delivering client-ready solutions while collaborating with stakeholders across various disciplin...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$150K - $180K *

Lead and optimize a dynamic security program, ensuring resilient systems while collaborating with teams and vendors to enhance security, scalability, and incident response throughout a Microsoft-based...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$66K - $102K *

Unlock your potential as a Senior SAP FICO Consultant, driving impactful solutions and collaborating with teams to enhance financial processes. Leverage your expertise to deliver value in a dynamic co...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$77K - $116K *

Deliver exceptional service by diagnosing and repairing complex biomedical equipment, ensuring customer satisfaction through effective communication and proactive maintenance strategies. Collaborate w...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Business Services

$135K - $160K *

Elevate user experiences by leading the development of innovative web features. Collaborate with cross-functional teams to deliver high-quality, customer-facing applications using modern technologies...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Unlock potential by overseeing a portfolio of enterprise accounts, fostering strategic partnerships, and driving user engagement to achieve measurable outcomes. Collaborate with internal teams to deli...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Legal & Accounting

$120K *

Partner with us to enhance product knowledge through comprehensive training programs, ensuring effective customer support and the growth of clinical expertise in the field sales organization. Be a cli...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$126K - $173K *

Champion the development of Provider Direct Connect capabilities, driving product vision and strategy while collaborating with cross-functional teams to enhance provider engagement and deliver scalabl...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$174K - $217K *

Drive strategic leadership in industry partnerships and payor strategy, enhancing market access and competitive positioning. Lead a high-performing team to execute a multiyear plan that fosters sustai...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $150K *

Innovate within a cutting-edge DataOps environment, ensuring the reliability and scalability of a Databricks-native data platform on Azure. Leverage AI for observability and pipeline management while...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$75K - $105K *

Tackle comprehensive project management for onboarding HME providers, driving digital transformation across healthcare. Collaborate strategically, enhance platform adoption, and leverage data insights...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$97K - $146K *

Partner with us to provide clinical support for contrast media, delivering education and product expertise to healthcare professionals while collaborating with internal teams to enhance patient care a...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$133K - $180K *

Join a team that's redefining member experiences by architecting optimal journeys, bridging operational execution with strategic vision to enhance engagement and satisfaction across all touchpoints...

United StatesRemote

Reposted 4 days ago

  •   11 - 15 years exp.  •   Healthcare

$58K - $125K *

Accelerate progress at the intersection of finance and strategy, driving cost accounting excellence and profitability analysis. Collaborate with cross-functional teams to enhance financial reporting a...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $124K *

Lead and optimize research intern activities, ensuring alignment with project goals and technical standards. Manage workflows, provide coaching, and conduct hands-on research while supporting the Dire...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$120K - $150K *

Drive customer satisfaction and sales in life sciences by leveraging your expertise to build relationships and execute strategic initiatives with key accounts in academia and industry...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$90K - $110K *

Shape the future of HR technology by managing and optimizing our HRIS. Serve as a vital expert, collaborating across departments to enhance system performance, streamline processes, and ensure data in...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Business Services

$120K - $145K *

Elevate healthcare through strategic AI product management, driving innovation and lifecycle management of AI solutions. Collaborate cross-functionally to align business objectives with customer needs...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$90K - $120K *

Grow your career with a dynamic team that drives sales growth through strategic customer engagement, market analysis, and solution identification, all while ensuring exceptional customer satisfaction...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$90K - $120K *

Drive sales growth by executing strategic plans, managing customer relationships, and addressing market needs while identifying new opportunities and solutions for an automotive-focused territory. 50...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$214K - $308K *

Empower security excellence by leading high-performing teams, driving strategic initiatives, and collaborating across functions. Own major security programs and represent the organization to executive...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.