Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$90K - $103K *
Develop and optimize health and welfare plans, ensuring compliance and efficient administration. Collaborate with TPAs, oversee claims performance, and enhance employee engagement through effective co...
1 month ago
Senior Cyber Security Engineer
$110K - $130K *
Lead the enhancement of security measures for cloud-based healthcare solutions, focusing on vulnerability management, incident response, and compliance. Collaborate with cross-functional teams to ensu...
1 week ago
$150K - $180K *
Lead the architectural direction of order-to-cash solutions across multiple customer engagements, ensuring effective design, integration, and adoption of SAP systems while leveraging AI tools for enha...
2 weeks ago
$170K - $200K *
Champion the evolution of exposure management by leading the design and implementation of a robust operating model, ensuring effective risk reduction and accountability across security operations and...
Reposted 6 days ago
Field Service Engineer - Image Guided Therapy (Field: Charlotte, NC)
$72K - $112K *
Serve as a vital link in healthcare by providing expert technical support for imaging equipment. You'll ensure optimal performance through installation, troubleshooting, and maintenance, while fosteri...
2 days ago
Director, ServiceNow Architect & Technical Delivery
$140K - $180K *
Empower teams by leading the technical vision and delivery standards for ServiceNow. Drive high-quality implementations across engagements while mentoring talent and collaborating with management to e...
Reposted 3 weeks ago
$148K - $163K *
Transform financial systems through leadership in automation, AI, and strategic planning. Oversee the integrity of core finance technology and collaborate across departments to enhance operational eff...
Reposted 3 weeks ago
Senior Principal, Business Management
$135K - $160K *
Drive strategic initiatives by developing KPI frameworks and operational dashboards, analyzing performance data, and collaborating across teams to enhance business outcomes and support informed decisi...
Today
Senior Budget Administrator - Clinical Trials
$100K - $161K *
Advance your career by coordinating clinical trial budgets and coverage analyses. Collaborate with stakeholders to ensure compliance and cost efficiency while mentoring junior staff and enhancing admi...
1 week ago
Senior Product and Design Strategist
$192K - $240K *
Unlock your potential as a Product + Design Strategist, leading ambiguous projects from concept to execution. Collaborate with cross-functional teams to create innovative, user-centered experiences an...
Reposted 4 weeks ago
$90K - $110K *
Join our new Data Engineering team to lead business intelligence initiatives, build trusted data models in Snowflake, and deliver impactful reports in Power BI. Collaborate with stakeholders to enhanc...
3 days ago
Specialty Development Executive - West Territory
$140K - $180K *
Advance healthcare by driving product adoption and education in colorectal cancer screening across a key geographic territory. Collaborate with healthcare providers to enhance market penetration and e...
Reposted 2 weeks ago
Senior Quality Assurance Engineer
$90K - $150K *
Join a team that's dedicated to ensuring software quality by developing and executing comprehensive tests. Collaborate with peers to enhance testing methodologies and mentor teammates in a dynamic and...
Reposted 3 weeks ago
$155K - $210K *
Empower your career by leading enterprise database architecture and transformation initiatives. Collaborate with executive stakeholders to drive innovation and establish best practices in modern data...
3 weeks ago
Forward Deployed Engineer - FDE - Healthcare
$110K - $130K *
Join a team that's transforming healthcare by connecting groundbreaking products with clients. You'll lead onboarding, design impactful use cases, and advocate for customer success, ensuring seamless...
Reposted today
Civil Estimator (EV Infrastructure)
$80K - $95K *
Manage civil construction estimates for EV charging projects, ensuring accurate pricing and proposal development. Collaborate with teams and stakeholders to identify risks and optimize project executi...
3 weeks ago
$87K - $120K *
Elevate customer success by managing IT projects, driving business development, and ensuring seamless platform integration for enterprise clients, enhancing satisfaction and ROI through effective solu...
2 weeks ago
Director, Industry Strategy & Engagement (Remote - USA)
$158K - $195K *
Accelerate progress at the intersection of agriculture and technology by leading strategic engagement with key stakeholders in the pork value chain, driving commercialization efforts, and fostering in...
3 weeks ago
Senior Product Security Engineer
$173K - $255K *
Join a dynamic team to enhance product security throughout the development lifecycle. Collaborate with engineering and product teams to identify vulnerabilities, automate processes, and implement secu...
2 days ago
Enterprise Business Development Manager Health, Beauty & Wellness
$105K - $155K *
Unlock potential by driving enterprise acquisition in Health, Beauty & Wellness. Lead outreach and negotiations with high-value merchants, shaping strategic partnerships that generate activated revenu...
Reposted 3 weeks ago
Senior Technical Product Manager - Insurance Products & Benefits
$104K - $143K *
Lead the charge in developing and delivering innovative technology solutions for managing Medicare/Medicaid plans. Collaborate with cross-functional teams to drive product vision, strategy, and execut...
Reposted 3 days ago
$95K - $115K *
Elevate customer success by guiding clients through their journey, maximizing product value, and fostering strategic partnerships. Collaborate cross-functionally to enhance user experience and drive r...
3 weeks ago
Senior Growth Marketing Manager, Consumer
$126K - $236K *
Lead the charge in consumer engagement and growth strategy, driving awareness and deepening user connections across channels. Collaborate cross-functionally to optimize campaigns that inspire action a...
3 days ago
Advanced Practice Provider - General & Bariatric Surgery
$90K - $110K *
Manage patient care under physician supervision, focusing on complex cases and collaborating with healthcare teams to ensure optimal outcomes and continuity of care...
6 days ago
General Manager, Healthcare Practices
$275K - $325K *
Drive the growth of healthcare practices by owning strategy, partnerships, and P&L. Collaborate with teams to deliver tailored financial solutions, while leveraging your network to establish Flex as t...
Yesterday
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.