Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Dentist Jobs in South Dakota

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$80K - $95K *

Empower the design process by leading in-house teams and managing consultants. Drive healthcare and commercial projects from concept to construction documents while establishing design standards and e...

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$200K - $225K *

Lead the strategic execution of facilities management across the Americas, overseeing financial performance, operational excellence, and talent development while ensuring client satisfaction and compl...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Real Estate & Construction

$195K - $237K *

Optimize the renter experience across digital platforms by leading design initiatives, balancing innovation with maintenance, and setting high standards for visual and interaction design. Collaborate...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$200K *

Lead the charge in building and scaling AI Data Operations, transforming emerging opportunities into commercially viable solutions. Drive strategy, partnerships, and operational excellence to support...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$91K - $152K *

Join a team that's dedicated to managing customer relationships and driving project success in the power generation sector. You'll oversee operations, ensure customer satisfaction, and contribute to s...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$123K - $169K *

Unlock your potential by providing expert clinical training and support to customers, ensuring they effectively operate advanced dosimetry equipment. Collaborate with cross-functional teams to enhance...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $100K *

Deliver exceptional mixed animal veterinary care, utilizing advanced equipment and collaborating with a skilled team to enhance patient outcomes while building meaningful client relationships...

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$175K - $250K *

Shape the cloud infrastructure for AI agents, ensuring secure, scalable solutions that enhance customer workflows. Lead architectural decisions, establish standards, and drive innovation in a dynamic...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$70K - $99K *

Collaborate with healthcare teams to deliver exceptional patient care through assessment, planning, and evaluation. Utilize nursing expertise to support patients across all care phases, ensuring adher...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $160K *

Oversee the operational planning and execution of clinical trials, ensuring compliance with regulatory standards while managing cross-functional teams to meet project timelines, budgets, and quality o...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$193K - $285K *

Champion the design and operation of security services, ensuring safety and resilience for delivery systems. Collaborate across teams to foster secure practices while guiding and mentoring engineers t...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$100K - $120K *

Transform your career by driving new business growth and client success in a dynamic remote environment. Leverage your sales expertise to build strategic partnerships and exceed revenue targets while...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$104K - $144K *

Unlock potential by serving as a consultative wound care expert, educating clinicians, driving product adoption, and managing accounts to enhance patient healing and business growth in a dynamic healt...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Drive strategic initiatives and operational excellence across a global portfolio, partnering with leadership to enhance business performance and deliver measurable outcomes in oncology and rare diseas...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Transform healthcare initiatives by leading projects from inception to completion. Coordinate teams, manage timelines, and ensure clear communication to drive organizational priorities and deliver mea...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$80K - $98K *

Build strong partnerships and drive new business growth by developing merchant services opportunities with businesses generating $1M-$10M in annual revenue, while managing a defined sales territory an...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$176K - $220K *

Lead the charge in driving sustainable revenue growth by managing a high-performing team of Account Executives focused on acquiring new clients in the financial sector, ensuring effective sales execut...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $100K *

Elevate your career by driving sales growth through strategic prospecting and collaboration. Leverage market knowledge and CRM tools to enhance customer relationships while managing a dynamic territor...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$120K - $150K *

Analyze and enhance data-driven analytics and machine learning models to support ammunition planning and resupply. Collaborate with teams to improve forecasting, automate workflows, and drive efficien...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Business Services

$105K - $155K *

Join a team that's redefining social media in healthcare. Lead strategic initiatives, drive impactful campaigns, and mentor talent while collaborating with clients to elevate their social presence acr...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$250K - $500K+*

Elevate risk management by leading enterprise risk, actuarial, and reinsurance strategies. Collaborate with senior leadership to ensure sound decision-making and governance, while protecting the balan...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Finance & Insurance

$120K - $145K *

Shape the future of data governance by leading a team to manage third-party data compliance, ensuring operational excellence and regulatory adherence while fostering collaboration across business unit...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$110K - $130K *

Unlock potential by leading Agile delivery teams and managing product backlogs. Collaborate with stakeholders to translate business needs into actionable user stories, ensuring alignment with strategi...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$164K - $262K *

Advance your career by designing and operating AI systems for mortgage Fulfillment. Lead architecture, build evaluation frameworks, and ensure reliability while collaborating with cross-functional tea...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$125K - $145K *

Shape the future of data governance by leading methods and standards across enterprise systems. Collaborate with teams to define quality rules and documentation, ensuring consistency and excellence in...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.