Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
$80K - $95K *
Empower the design process by leading in-house teams and managing consultants. Drive healthcare and commercial projects from concept to construction documents while establishing design standards and e...
3 weeks ago
$200K - $225K *
Lead the strategic execution of facilities management across the Americas, overseeing financial performance, operational excellence, and talent development while ensuring client satisfaction and compl...
Today
Senior Staff Product Designer, Core
$195K - $237K *
Optimize the renter experience across digital platforms by leading design initiatives, balancing innovation with maintenance, and setting high standards for visual and interaction design. Collaborate...
3 weeks ago
$200K *
Lead the charge in building and scaling AI Data Operations, transforming emerging opportunities into commercially viable solutions. Drive strategy, partnerships, and operational excellence to support...
3 weeks ago
Lead Services Specialist - Contract Performance Mgmt
$91K - $152K *
Join a team that's dedicated to managing customer relationships and driving project success in the power generation sector. You'll oversee operations, ensure customer satisfaction, and contribute to s...
6 days ago
Clinical Applications Specialist - Dosimetrist (Travelling position)
$123K - $169K *
Unlock your potential by providing expert clinical training and support to customers, ensuring they effectively operate advanced dosimetry equipment. Collaborate with cross-functional teams to enhance...
1 week ago
Mixed Animal Veterinarian at Sturgis Veterinary Hospital and Equine Center
$85K - $100K *
Deliver exceptional mixed animal veterinary care, utilizing advanced equipment and collaborating with a skilled team to enhance patient outcomes while building meaningful client relationships...
Reposted 2 weeks ago
Principal Cloud Engineer - AI Platform
$175K - $250K *
Shape the cloud infrastructure for AI agents, ensuring secure, scalable solutions that enhance customer workflows. Lead architectural decisions, establish standards, and drive innovation in a dynamic...
2 weeks ago
RN - Registered Nurse - RCC - Days
$70K - $99K *
Collaborate with healthcare teams to deliver exceptional patient care through assessment, planning, and evaluation. Utilize nursing expertise to support patients across all care phases, ensuring adher...
3 weeks ago
Associate Director, Clinical Operations
$130K - $160K *
Oversee the operational planning and execution of clinical trials, ensuring compliance with regulatory standards while managing cross-functional teams to meet project timelines, budgets, and quality o...
2 weeks ago
Staff Security Engineer, Proactive Security - AI
$193K - $285K *
Champion the design and operation of security services, ensuring safety and resilience for delivery systems. Collaborate across teams to foster secure practices while guiding and mentoring engineers t...
Reposted 3 weeks ago
$100K - $120K *
Transform your career by driving new business growth and client success in a dynamic remote environment. Leverage your sales expertise to build strategic partnerships and exceed revenue targets while...
1 week ago
Post-acute Wound Healing Specialist (Seattle North area)
$104K - $144K *
Unlock potential by serving as a consultative wound care expert, educating clinicians, driving product adoption, and managing accounts to enhance patient healing and business growth in a dynamic healt...
Today
Director, Business Improvement
$150K - $180K *
Drive strategic initiatives and operational excellence across a global portfolio, partnering with leadership to enhance business performance and deliver measurable outcomes in oncology and rare diseas...
1 week ago
Healthcare Program & Project Manager (Remote)
$80K - $95K *
Transform healthcare initiatives by leading projects from inception to completion. Coordinate teams, manage timelines, and ensure clear communication to drive organizational priorities and deliver mea...
Yesterday
Business Banking Merchant Account Executive
$80K - $98K *
Build strong partnerships and drive new business growth by developing merchant services opportunities with businesses generating $1M-$10M in annual revenue, while managing a defined sales territory an...
1 week ago
$176K - $220K *
Lead the charge in driving sustainable revenue growth by managing a high-performing team of Account Executives focused on acquiring new clients in the financial sector, ensuring effective sales execut...
Today
Sales Representative New Business Midwest US
$80K - $100K *
Elevate your career by driving sales growth through strategic prospecting and collaboration. Leverage market knowledge and CRM tools to enhance customer relationships while managing a dynamic territor...
3 weeks ago
Data Scientist - Clearance Required
$120K - $150K *
Analyze and enhance data-driven analytics and machine learning models to support ammunition planning and resupply. Collaborate with teams to improve forecasting, automate workflows, and drive efficien...
3 days ago
$105K - $155K *
Join a team that's redefining social media in healthcare. Lead strategic initiatives, drive impactful campaigns, and mentor talent while collaborating with clients to elevate their social presence acr...
1 week ago
Stonehaven - Chief Risk Officer
$250K - $500K+*
Elevate risk management by leading enterprise risk, actuarial, and reinsurance strategies. Collaborate with senior leadership to ensure sound decision-making and governance, while protecting the balan...
2 weeks ago
Senior Manager, Third Party Data Governance
$120K - $145K *
Shape the future of data governance by leading a team to manage third-party data compliance, ensuring operational excellence and regulatory adherence while fostering collaboration across business unit...
Today
Senior Product Owner (HYBRID - LOCAL CANDIDATES ONLY, DALLAS TX)
$110K - $130K *
Unlock potential by leading Agile delivery teams and managing product backlogs. Collaborate with stakeholders to translate business needs into actionable user stories, ensuring alignment with strategi...
6 days ago
Senior Fullstack Engineer, Mortgage Fulfillment AI
$164K - $262K *
Advance your career by designing and operating AI systems for mortgage Fulfillment. Lead architecture, build evaluation frameworks, and ensure reliability while collaborating with cross-functional tea...
1 week ago
Associate Director, Methods and Data Standards
$125K - $145K *
Shape the future of data governance by leading methods and standards across enterprise systems. Collaborate with teams to define quality rules and documentation, ensuring consistency and excellence in...
6 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.