Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Dentist Jobs in South Dakota

Sort By: Relevance

$150K - $180K *

Champion growth by leading national accounts, driving strategy, and enhancing partnerships with specialty distributors and GPOs. Leverage expertise to ensure product availability and exceed corporate...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$71K - $107K *

Elevate healthcare education by designing and implementing training programs that enhance maternal and infant health outcomes. Collaborate with clinical and community partners to translate evidence-ba...

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$85K - $95K *

Drive technical sales growth through customer engagement and training. Oversee value-driven sales processes in the western Connecticut territory, while collaborating internally to exceed customer expe...

RemoteRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$92K - $138K *

Help us enhance clinical education by delivering expert training and support to healthcare professionals. Drive product adoption and optimize user competencies while fostering strong relationships wit...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$88K - $105K *

Join a dynamic team to drive enterprise-wide transformation initiatives, leveraging data analysis and AI to enhance performance and innovation across departments, while fostering collaboration and ali...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Elevate operational efficiency by managing account priorities and delivering proactive business solutions. Collaborate with teams to ensure high-quality service and maintain strong relationships with...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$94K - $151K *

Join a team that's shaping the future of insurance products by leading strategic initiatives, ensuring compliance, and driving market analysis. Collaborate with product managers to define vision and e...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Join a team that's driven to build a powerful growth engine through hands-on management of acquisition campaigns and lifecycle marketing, integrating data analysis, creative collaboration, and automat...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$110K - $130K *

Join a dynamic team providing empathetic pharmacy consulting and clinical services. Oversee pharmacy operations, enhance patient experiences, and manage staff performance while ensuring compliance wit...

6 days ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$175K - $210K *

Lead operational excellence in biopharmaceutical manufacturing, overseeing GMP processes, technology transfers, and clinical supply. Drive strategic initiatives, manage CDMO relationships, and build a...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$110K - $165K *

Drive impactful clinical and technical research initiatives across global teams, ensuring project success from planning to execution. Collaborate with cross-functional partners to meet quality, budget...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$217K - $294K *

Innovate the U.S. Cardiovascular & Metabolic Medical strategy, leading evidence generation and stakeholder engagement for chronic weight management. Collaborate cross-functionally to ensure launch rea...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Develop strategic leadership for a team managing complex client portfolios, driving retention, growth, and client experience objectives while fostering strong relationships with stakeholders and ensur...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $155K *

Take ownership of the health, safety, and environmental initiatives, ensuring compliance and risk management for large clients. Leverage comprehensive industry knowledge to influence stakeholders and...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$150K - $180K *

Unlock potential by driving partnerships within health systems, building strategic relationships, and creating impactful ecosystems that accelerate product adoption and streamline sales cycles, while...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Healthcare

$85K - $115K *

Elevate healthcare education by developing evidence-based content for clinicians. Collaborate with experts to create innovative learning materials that address practice gaps and enhance professional s...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$150K - $250K *

Transform financial services by leading complex banking operations and technology projects. Collaborate with clients to enhance performance, drive innovation, and shape a new practice within a dynamic...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Business Services

$183K - $270K *

Join us in shaping the future of cybersecurity law by providing strategic legal guidance on cybercrime investigations and enforcement. Your expertise will directly influence our approach to legal chal...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$160K - $192K *

Join a dynamic team to drive commercial performance and enhance patient access through strong relationships with healthcare providers, executing strategic business plans and supporting innovative prod...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$75K - $158K *

Join a team that's dedicated to optimizing operations in a fast-paced environment. Support technical and functional stakeholders while ensuring seamless processing and troubleshooting across systems...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$82K - $172K *

Transform complex data ecosystems by leveraging your Elasticsearch expertise to design, optimize, and lead advanced analytics initiatives. Collaborate with cross-functional teams to enhance mission-cr...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$244K - $279K *

Lead innovation as a key technical expert, driving cloud-based banking solutions while collaborating on scalable, high-volume payment systems in a dynamic engineering environment. Shape the future of...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$200K - $300K *

Shape the finance and accounting infrastructure, ensuring accurate financials and compliance. Collaborate with teams to manage bordereaux data, oversee reinsurance accounting, and establish robust fin...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$83K - $103K *

Drive success in regulatory affairs by preparing critical submissions for medical and diagnostic devices. Oversee compliance with U.S. and international regulations while collaborating with cross-func...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$220K - $255K *

Shape the future of healthcare by leading strategic payor relationships and driving reimbursement strategies. Collaborate cross-functionally to enhance patient access and optimize coverage for innovat...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.