Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Dentist Jobs in South Dakota

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$150K - $215K *

Lead the charge in developing a cutting-edge compliance program for consumer financial products. You'll oversee a team, drive strategy, and ensure adherence to regulations in a fast-paced, innovative...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$90K *

Shape the future of business analysis by connecting program needs with technical solutions. Leverage your Salesforce expertise to enhance workflows, gather requirements, and collaborate with stakehold...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$106K - $176K *

Join a team that's transforming healthcare finance by leading patient financial services operations. Drive revenue cycle improvements, manage billing processes, and enhance compliance while fostering...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Business Services

$220K - $250K *

Shape the future of neurology by building partnerships with Medical Experts, generating insights, and collaborating across teams to enhance patient care and drive innovation in a dynamic healthcare la...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$70K - $99K *

Empower your career by delivering personalized nursing care in a top-rated facility. Utilize your expertise to collaborate with a dedicated team, ensuring excellence in resident care and rehabilitatio...

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $210K *

Drive the execution of a comprehensive medical affairs plan for prostate cancer theranostics, collaborating across functions to enhance strategy, launch readiness, and lifecycle planning while advanci...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Pioneer customer success by nurturing strategic relationships, driving product adoption, and ensuring satisfaction. Leverage your expertise to mentor junior team members and shape customer success str...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$66K - $99K *

Play a key role in delivering exceptional outpatient nursing care by assessing, planning, and implementing individualized patient care in collaboration with a multidisciplinary team, ensuring adherenc...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$175K - $250K *

Unlock potential by leading pricing strategy and actuarial modeling for Commercial lines, ensuring regulatory compliance and operational excellence while collaborating across teams to drive profitable...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$102K - $174K *

Join a team that's redefining user experiences in Robotics and Autonomous Systems. As a UI/UX Designer, you'll create intuitive interfaces, conduct user research, and collaborate with developers to de...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$135K - $160K *

Innovate by leading the architectural transformation of a legacy platform into a scalable, AI-driven solution. Your expertise will guide modernization efforts while enhancing performance and security...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to precision and efficiency in accounting. Lead the monthly close process, manage reconciliations, and collaborate cross-functionally in a fast-paced environment, ensuring...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$138K - $201K *

Transform provider analytics by leading data-driven insights for contracting, performance, and network strategy. Collaborate with cross-functional teams to enhance network adequacy and drive strategic...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$105K - $129K *

Drive impactful market analysis and reporting as a Senior Analyst, leveraging data to guide strategic investments and growth opportunities. Collaborate with teams to enhance decision-making and optimi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$116K - $145K *

Unlock potential by leading payer negotiations and expanding access across commercial, Medicare, and Medicaid sectors. Drive strategic partnerships and ensure compliance while maximizing patient acces...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $150K *

Transform accounting operations by bridging customer workflows and AI-driven solutions. Engage in pre-sale discovery, design automated solutions, and ensure accurate implementation, all while collabor...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$134K - $145K *

Optimize commercial accounting processes by managing revenue, inventory, and accounts receivable. Collaborate with cross-functional teams to ensure accurate financial reporting and drive process impro...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$120K - $145K *

Pioneer the development of secure platform capabilities for enterprise clients, collaborating across teams to define product scope, manage complex requirements, and ensure successful delivery in highl...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$108K - $169K *

Champion pediatric development by delivering impactful therapy in children's natural environments. Collaborate with families and interdisciplinary teams to foster independence and confidence in every...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$85K - $128K *

Unlock potential by driving cloud security sales initiatives, collaborating with teams, establishing partnerships with key personas, and engaging customers to integrate innovative security solutions i...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Elevate your career by preparing and analyzing complex Medicaid cost reports, ensuring compliance with regulations, and leading a team of accountants in a remote setting. Drive process improvements an...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

$250K - $300K *

Shape the future of AI-powered implementations by leading a dynamic team, redefining best practices, and building a robust partner ecosystem to enhance client success and drive growth in a fast-paced...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Business Services

$128K - $165K *

Empower Fraud Operations by leading AI-driven automation initiatives, enhancing investigative workflows, and delivering actionable insights to optimize fraud detection and prevention efforts across th...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $180K *

Lead Corporate FP&A initiatives, driving budgeting, forecasting, and performance management. Oversee financial analysis and reporting while enhancing systems and dashboards for improved decision-makin...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$117K - $164K *

Transform your career by leading Identity and Access Management initiatives, enhancing security protocols, and driving automation in a dynamic IT environment. Collaborate with cross-functional teams t...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.