Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

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1,000+

Dentist Jobs in South Dakota

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$120K - $180K *

Shape the future of regulatory intelligence by leading cross-functional teams, managing global surveillance workstreams, and translating complex regulations into actionable insights for stakeholders a...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Champion the development of AI-driven products, leading strategic initiatives and execution. Drive product roadmaps, manage budgets, and ensure alignment with business goals while delivering impactful...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Join a team that's redefining product management by leading AI and automation initiatives. Drive strategic roadmaps, enhance operational efficiency, and deliver impactful solutions while collaborating...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$102K - $120K *

Lead the charge in driving product strategy and execution for AI applications, ensuring high-quality delivery and alignment with business outcomes. Collaborate with cross-functional teams to optimize...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Elevate your career by leading the strategic growth of our Attorney Banking Division. Drive business development, mentor a remote team, and enhance client experiences while achieving personal producti...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Engage in project leadership by overseeing digital delivery aspects, support teams through the lifecycle of BIM projects, and ensure quality control while mentoring and guiding staff for optimal perfo...

Reposted today

  •   5 - 7 years exp.  •   Real Estate & Construction

$160K - $180K *

Unlock potential by leading application security initiatives, enhancing product security, and driving secure development practices. Collaborate with engineering teams to establish standards, manage vu...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$86K - $138K *

Champion financial analysis and reporting by conducting in-depth research, preparing forecasts, and collaborating across departments to enhance decision-making and drive business success...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $165K *

Lead the charge in developing strategic initiatives that enhance organizational performance, collaborating with executives to drive business growth and improve competitive positioning through data-dri...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $190K *

Join us in shaping the future of Fair Lending solutions. Drive product strategy, deliver expert analysis, and enhance client outcomes while navigating complex regulatory landscapes. Your expertise wil...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Finance & Insurance

$125K - $150K *

Accelerate your career by driving growth in healthcare sales. Leverage your expertise to build relationships with key accounts, navigate complex deals, and shape future services that impact the indust...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$160K - $280K *

Join us to architect and build a cutting-edge web platform, driving marketing innovation through AI agents. Own technical decisions, enhance user experiences, and ensure seamless integration with our...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $108K *

Unlock potential by providing essential data management and help desk support for public health initiatives, ensuring efficient operations and user assistance in a dynamic healthcare environment...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$100K - $120K *

Join a team that's dedicated to enhancing clinical operations through strategic site identification and management. Leverage your expertise to build relationships, track project timelines, and contrib...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $200K *

Join a team that's shaping the future of self-funded health plans by drafting and negotiating critical contracts. Collaborate with cross-functional teams to ensure compliance and drive business succes...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$165K - $264K *

Pioneer cross-functional collaboration to manage IS projects, ensuring successful implementation and support of applications, upgrades, and integrations while overseeing budgets and resources across S...

RemoteRemote

2 days ago

  •   8 - 10 years exp.  •   Healthcare

$100K - $140K *

Transform your career by providing clinical support and training in surgical procedures. Collaborate with surgical teams to ensure optimal patient outcomes while managing inventory and compliance in a...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $159K *

Join us to foster an innovative educational environment, providing leadership and mentorship while enhancing curriculum and teaching methodologies to ensure student success and engagement in learning...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$212K - $318K *

Shape the future of patient-centered outcomes in oncology by leading global strategies for clinical assessments and patient experience data, ensuring impactful evidence generation and regulatory succe...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$130K - $140K *

Accelerate growth and expand market presence by developing strategic sales initiatives, managing national accounts, and building key industry relationships in the commercial real estate sector. Drive...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$109K - $136K *

Drive accurate, evidence-based clinical claims while collaborating with Marketing, Legal, and Clinical teams. Build and manage the claims framework and evidence library to support bold, compliant mark...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Contribute to the success of multiple clinical research sites by leading operations, ensuring compliance with regulations, and fostering team development to enhance patient care and operational excell...

United StatesRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Shape the future of legal operations by leading a dynamic team focused on automation and technology. Drive efficiency in contract management and vendor relationships while defining metrics that enhanc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $100K *

Join a team that's focused on driving financial accuracy while managing month-end closes, reconciliations, and cost accounting. Contribute to board-level reporting in a dynamic PE-backed SaaS environm...

United StatesRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.