Explore $100K+ Jobs in South Dakota

Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.

South Dakota career opportunities

South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.

Where to find jobs

Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.

Find the right role on Ladders

Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down
400

Dentist Jobs in South Dakota

Sort By: Relevance

$100K - $120K *

Join a team that's dedicated to providing exceptional anesthetic care in a Level II Trauma Center. Engage in diverse procedures and enjoy a supportive work environment with opportunities for professio...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Unlock potential by joining a dynamic anesthesia team at a Level II Trauma Center, where you'll practice diverse techniques and collaborate closely with anesthesiologists to ensure safe, effective pat...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$210K *

Elevate patient care by delivering high-quality telehealth services across South Dakota. Join a compassionate team of board-certified physicians managing diverse clinical cases through innovative virt...

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$71K - $95K *

Empower the future of EDI and integration systems by designing, developing, and managing solutions that enhance business processes, ensuring reliability and efficiency while collaborating with cross-f...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$175K - $250K *

Join a team that's optimizing medical cost management and driving financial performance across Commercial lines. Leverage your expertise in healthcare economics to influence strategic contracting and...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$79K - $127K *

Unlock insights into medical cost trends by leveraging data analytics. Collaborate with cross-functional teams to develop strategic recommendations, track program outcomes, and present findings clearl...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$227K - $385K *

Elevate member care by overseeing utilization management and evaluating treatment appropriateness. Collaborate with multidisciplinary teams, ensuring compliance with clinical standards and regulations...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Champion effective publication strategies and lead scientific communication initiatives, acting as a strategic partner to clients and teams. Navigate complex medical affairs content to drive impactful...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Drive commercial performance by engaging healthcare providers and executing territory plans. Collaborate with cross-functional teams to support product launches and ensure patient access to innovative...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$250K - $275K *

Join us to lead clinical operations for a multi-state virtual care team, ensuring high-quality, timely care. This role combines direct patient care, administrative leadership, and strategic oversight...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Healthcare

$174K - $374K *

Strategize clinical oversight and drive innovative medical management programs. Collaborate with a multidisciplinary team to enhance member care outcomes while representing the organization to externa...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$75K - $90K *

Empower patients to achieve optimal physical health by evaluating needs, creating tailored care plans, and delivering effective treatments. Collaborate with a dedicated team to enhance patient outcome...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$100K - $120K *

Elevate your career by leading financial planning and analysis, managing budgets, and driving strategic insights. Collaborate with cross-functional teams to enhance operational performance and deliver...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$138K - $172K *

Empower revenue teams as a Senior Business Systems Analyst, driving efficiency through Salesforce architecture, process design, and actionable data across GTM, Marketing, Sales, and Customer Success o...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$125K - $150K *

Transform technology operations by leading IT and cybersecurity strategies, ensuring secure, scalable systems while enhancing employee support in a dynamic, remote-first environment. Collaborate acros...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Food & Beverages

$72K - $99K *

Join a team that's dedicated to enhancing employee experience and office operations. You'll manage daily office functions, foster a vibrant culture, and support executive initiatives, ensuring a welco...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Unlock potential by managing and optimizing project-level agreements, ensuring compliance and efficiency in contracting processes while supporting global operations and client needs in a dynamic legal...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$300K *

Drive excellence in wound management by providing bedside care in diverse facilities. Enjoy a flexible schedule with no nights or weekends, while earning competitive compensation and gaining expertise...

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$66K - $102K *

Join a dedicated team to operate mammography equipment, ensuring quality imaging and patient care. Contribute to women's health by performing examinations, educating clients, and maintaining safety st...

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$78K - $107K *

Drive financial integrity by managing complex accounting tasks, preparing reports, and influencing departmental strategy. Collaborate with teams to ensure compliance and accuracy while providing valua...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$100K - $125K *

Manage and analyze professional liability and medical malpractice claims, ensuring compliance and optimal outcomes through collaboration with counsel and specialty resources. Drive strategic claim res...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Staffing

$175K - $210K *

Lead the charge in driving enterprise growth within healthcare by building relationships with national and regional health plans. Own new logo acquisition and expansion, leveraging a robust support sy...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$110K - $182K *

Transform laboratory services by providing expert clinical consultation, enhancing service delivery, and fostering collaboration with healthcare professionals to meet strategic healthcare goals...

1 month ago

  •   Less than 5 years exp.  •   Healthcare

$88K - $149K *

Join a dynamic team in evaluating medication prior authorizations while developing clinical criteria and working closely with healthcare providers to ensure quality patient care through evidence-based...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$118K - $196K *

Lead the charge in developing and executing drug formulary strategies, ensuring compliance with regulations while collaborating with cross-functional teams to enhance pharmacy utilization management a...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000-plus jobs are available in South Dakota?question toggle

    Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.

  • Which South Dakota cities have professional job opportunities?question toggle

    Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.

  • How can I find high-paying jobs in South Dakota?question toggle

    Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.

  • Do South Dakota jobs listed on Ladders all pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.