Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Regional Sales Director - San Francisco
$180K - $215K *
Drive regional sales success by leading a high-performing team, executing launch strategies, and fostering customer relationships to achieve business objectives in a dynamic environment...
1 week ago
$100K *
Drive data-driven decision-making by developing automated reporting solutions. Collaborate with cross-functional teams to enhance enterprise reporting, ensuring accuracy and efficiency while translati...
3 weeks ago
$120K - $145K *
Advance healthcare solutions by developing scalable ML systems, collaborating with cross-functional teams, and driving innovative AI methodologies to enhance patient outcomes and optimize operational...
Reposted today
Senior Director, Corporate Counsel
$175K - $210K *
Lead corporate legal strategy and M&A transactions, guiding complex deals and governance. Manage a growing legal team, develop processes, and partner with senior leadership to drive business initiativ...
1 week ago
$80K - $95K *
Join a team that's redefining healthcare recruiting by building and scaling a high-impact Direct Employer business through innovative sales strategies and cutting-edge technology, driving growth direc...
Reposted 4 weeks ago
$90K - $110K *
Innovate technical SEO strategies to enhance global web performance, ensuring optimal search visibility and user experience. Collaborate with cross-functional teams to identify and resolve technical i...
2 weeks ago
$73K - $100K *
Elevate workforce planning by transforming data into impactful insights. Partner with leaders to build strategic forecasting tools and measure performance metrics, contributing to operational efficien...
Reposted 3 days ago
$170K - $185K *
Join a dynamic team to define and lead product strategy for Family Building Navigation, enhancing member engagement through innovative digital experiences and personalized support while collaborating...
6 days ago
Senior Analyst, Decision Science (Client Marketing)
$105K - $129K *
Elevate client engagement through data-driven insights! As a Senior Analyst, you'll analyze performance metrics, enhance marketing strategies, and drive client retention, ensuring impactful decisions...
1 week ago
$92K - $120K *
Join a dynamic team as a Medical Claims Auditor, ensuring compliance and integrity in healthcare payments. Collaborate with cross-functional teams to identify fraud, waste, and abuse while leveraging...
Yesterday
Vice President, Growth (Pharma)
$150K - $200K *
Join a dynamic team to drive growth in the pharmaceutical sector, leveraging your expertise to build relationships, win new business, and deliver impactful solutions that enhance brand performance and...
Today
$150K - $180K *
Transform your career as a strategic finance leader, driving financial operations and strategic planning. Own the P&L, balance sheet, and cash flow while partnering with executives to shape growth and...
4 weeks ago
Contract and Billing Specialist
$84K - $128K *
Join a team that's dedicated to resolving complex billing and contract cases for Mid-Market and Commercial accounts. You'll collaborate cross-functionally to enhance customer satisfaction and streamli...
1 week ago
$112K - $195K *
Accelerate progress at digital modernization initiatives by leading human-centered product design. Collaborate with diverse teams to enhance workflows, automate processes, and create AI-enabled experi...
2 weeks ago
Senior Associate Sourcing Consultant
$80K - $95K *
Drive procurement excellence by supporting cross-functional teams in vendor governance and sourcing. Leverage analytical skills to improve processes and mitigate risks while crafting strategic solutio...
Reposted 3 weeks ago
SAP Principal Delivery Architect
$150K - $180K *
Transform customer engagements by owning solution direction across multiple accounts. Drive platform adoption, orchestrate delivery teams, and shape opportunities to ensure measurable value and long-t...
3 weeks ago
Nurse Practitioner | Avera at Home
$92K - $110K *
Provide comprehensive medical care by assessing and treating patients, collaborating with physicians, and ensuring quality health education. Contribute to patient safety and care standards while maint...
2 weeks ago
VP, Labor & Public Sector Sales
$215K - $250K *
Pioneer your career by leading a dynamic sales team focused on Labor and Public Sector markets. Drive growth, mentor talent, and execute strategic initiatives to exceed revenue goals while building im...
2 weeks ago
$88K - $140K *
Shape the future of public service by leading technology consulting projects that enhance operational efficiency and strategic goals for state and local agencies, ensuring compliance and delivering im...
2 weeks ago
Consultant Relations Senior Manager
$170K - $200K *
Elevate our Enterprise business by building impactful relationships with brokers and consultants. Drive engagement strategies, generate new business opportunities, and enhance BetterHelp's presence in...
2 weeks ago
VP OF SALES - EAST COAST - HEALTHCARE
$160K - $200K *
Empower your career by leading a high-performing sales team to drive profitable growth in the healthcare sector. Develop and execute strategic sales initiatives, foster client relationships, and ensur...
Reposted 3 days ago
$104K - $143K *
Shape the future of pharmacy software by leading product strategy, managing cross-functional teams, and driving improvements in patient outcomes and business results through innovative product managem...
3 days ago
Healthcare Tech Manager - Epic Patient Access
$130K - $150K *
Drive impactful solutions as a Healthcare Technology Manager, optimizing Epic Patient Access systems. Collaborate with clients and teams to enhance workflows and deliver sustainable results in a suppo...
2 weeks ago
Complex Pediatric Clinical Psychologist
$80K - $95K *
Transform pediatric care by integrating psychological services within a dynamic, interdisciplinary team. Collaborate with healthcare professionals to support children and families, addressing emotiona...
4 weeks ago
$90K - $110K *
Analyze and optimize workforce management strategies across multiple business lines, translating complex forecasts into actionable capacity plans and financial models while collaborating with executiv...
3 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.