Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Clinical Psychologist (Remote)
$120K - $130K *
Shape the future of mental health care by providing virtual counseling and developing treatment plans for patients with acute conditions. Collaborate with medical professionals while ensuring adherenc...
1 week ago
Lead AI and Data Solution Engineer
$200K - $215K *
Drive the design and deployment of innovative data and AI solutions, leveraging expertise in LLMs, agentic AI, and cloud technologies to enhance business value and ensure compliance with industry stan...
3 weeks ago
Director of Consultant Relations
$110K - $130K *
Unlock potential by cultivating strategic relationships with benefits consultants and brokers. Drive revenue growth through effective partnerships, collaboration with cross-functional teams, and exper...
2 weeks ago
$66K - $169K *
Lead product quality initiatives to ensure compliance and continuous improvement throughout the product lifecycle, partnering with cross-functional teams to enhance manufacturing performance and suppo...
Reposted 6 days ago
Regional Sales Director - Midwest
$180K - $215K *
Develop and lead regional strategies to drive product launch success, ensuring alignment with corporate goals. Build a high-performing team, foster customer relationships, and execute data-driven deci...
1 week ago
Senior Market Research Consultant
$84K - $152K *
Unlock potential by driving strategic initiatives across marketing, product development, and operations. Collaborate with leadership and teams to identify performance gaps and translate data into acti...
1 week ago
Account Manager - Neurosurgery - (Orange County - California)
$100K - $120K *
Partner with us to drive sales in the Neurosurgery product line, achieving revenue targets through strategic planning, relationship building, and exceptional customer service in a dynamic operating ro...
1 week ago
Global Regulatory Affairs Director - Inflammation and Rare Disease
$189K - $256K *
Join a global team to shape regulatory strategies in biotechnology, supporting product development and lifecycle management in Inflammation and Rare Diseases. Lead regulatory efforts, ensure complianc...
1 month ago
Physical Therapist | Physical Therapist | Shift 5x8 Days
$82K *
Join a team that's dedicated to enhancing patient mobility and function. Provide expert physical therapy services, develop personalized treatment plans, and collaborate with care teams to ensure optim...
Today
$188K - $245K *
Empower innovation by leading a UX design team focused on clinical workflows. Collaborate across functions, drive strategic direction, and enhance AI integration while advancing design quality in heal...
4 weeks ago
EHR Applications Analyst II, Claims
$70K - $105K *
Collaborate with cross-functional teams to enhance EHR workflows, improve operations, and optimize patient care through effective configuration and analysis of Professional Billing Claims applications...
1 week ago
National Accounts Lead Director, Clinical Program Consultant (CPC)
$100K - $231K *
Transform healthcare outcomes by leading a team of Clinical Program Consultants to analyze data, optimize clinical programs, and drive strategic initiatives that enhance customer health and reduce cos...
Today
Payment Integrity Clinical Readmission Manager
$73K - $125K *
Transform clinical review processes by conducting thorough prepayment and post-payment assessments of inpatient admissions. Leverage your expertise to ensure compliance, support appeals, and enhance q...
3 weeks ago
Solution Engineer (Billing Specialist)
$105K - $130K *
Join a team that's redefining billing solutions in the legal sector. Leverage your expertise in law firm financial operations to support sales efforts, conduct client demos, and enhance our innovative...
3 weeks ago
Product Manager, Clinical Programs & Case Management
$86K - $138K *
Unlock innovative healthcare solutions by leading product strategy and lifecycle management for clinical programs. Collaborate across teams to enhance member experiences and drive business value while...
1 week ago
$120K - $145K *
Join a team that's dedicated to safeguarding sensitive health information while enhancing security across cloud and application environments. As a Senior Security Engineer, you'll design and implement...
Today
Vice President Sales, TeleNeph LLC
$100K *
Elevate sales strategies by owning the full sales cycle, building C-Suite relationships, and delivering impactful solutions to healthcare organizations across the Western US...
2 weeks ago
Manager of Clinical Engagement
$115K - $130K *
Join a team that's redefining clinical engagement by leading strategic initiatives to enhance clinician pipelines, improve hiring processes, and foster partnerships across multiple regions, driving or...
4 days ago
$80K - $110K *
Analyze and support value-based care initiatives, developing innovative forecasting solutions and methodologies. Collaborate across teams to translate complex data into actionable insights that guide...
Reposted 3 days ago
Associate Director, Regional Clinical Study Management
$143K - $193K *
Transform clinical operations by leading regional study delivery, ensuring quality and compliance while managing timelines and budgets. Collaborate with cross-functional teams to drive study success a...
3 weeks ago
Senior Manager - Dazodalibep HCP Launch Marketing
$149K - $202K *
Transform the HCP launch landscape by leading innovative marketing initiatives for a groundbreaking treatment in Sjögren's disease. Collaborate cross-functionally to engage healthcare professionals an...
Yesterday
$110K - $118K *
Join a team that's driving strategic financial decisions by managing complex Treasury activities, analyzing risks, and enhancing operational efficiencies. Influence liquidity and banking relationships...
1 week ago
$110K - $130K *
Join a team that's driving financial strategy and operations, leading forecasting, reporting, and analysis to support a fast-growing organization with impactful decision-making and collaboration acros...
Reposted 4 weeks ago
$110K - $130K *
Drive innovative solutions by leveraging data analytics and strategic counsel to enhance client performance. Collaborate with high-performing teams to deliver tailored insights for transformational ev...
1 week ago
Director, Health Systems Partnerships
$190K - $240K *
Elevate healthcare impact by building and scaling enterprise accounts in women's health. Own the sales cycle, engage stakeholders, and drive screening initiatives while collaborating across teams to e...
Reposted 4 weeks ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.