Find vetted professional opportunities in South Dakota with salaries of $100,000 or more on Ladders. From established employers in Sioux Falls and Rapid City to roles across the state, explore openings for experienced professionals seeking their next career move.
South Dakota’s economy includes healthcare, financial services, manufacturing, technology, agriculture, energy, and professional services. High-paying positions may include leadership, specialized technical, clinical, sales, and operations roles. Availability and compensation vary by employer, location, and experience.
Sioux Falls is a major center for healthcare, finance, and business services, while Rapid City offers opportunities in healthcare, tourism, government, and regional services. Employers in smaller cities and rural areas may also hire for specialized and senior-level positions.
Browse South Dakota listings, review salary and experience requirements, and focus your search on positions that match your expertise and career goals. New opportunities may be added as employers hire, so check back regularly.
Sr Global Product Manager, Digital Solutions - Surgical & Procedural Care
$149K - $224K *
Lead the charge in shaping digital solutions for perioperative workflows, driving strategy and execution across cross-functional teams to enhance clinical outcomes and operational efficiency in surgic...
6 days ago
$110K - $130K *
Drive the evolution of a comprehensive design system, enhancing user experiences across web and mobile platforms. Collaborate with engineering and product teams to ensure quality, accessibility, and c...
2 days ago
Specialty Development Executive - North Central Territory
$130K - $140K *
Help us drive the adoption of innovative colorectal cancer screening solutions by effectively engaging healthcare providers through education, consultation, and strategic support in your assigned terr...
Reposted 2 weeks ago
1740 - Director, Strategic Sourcing Facilities- Healthcare
$125K - $185K *
Transform the future of healthcare sourcing by leading strategic initiatives, managing a dedicated team, and driving cost-saving projects across Facilities categories to ensure high-quality service de...
2 weeks ago
$100K - $120K *
Drive evidence-based healthcare improvements by leading evaluations and strategic analyses. Collaborate with multidisciplinary teams to enhance Military Health System outcomes through expert consultat...
3 weeks ago
$85K - $97K *
Shape the future of healthcare by conducting clinical case reviews and enhancing product quality for an AI-driven clinical platform. Collaborate with care teams to ensure accurate alert functionality...
4 weeks ago
Solution Architect, Legal Billing
$130K - $145K *
Help us design and implement billing solutions for law firms, leveraging your accounting expertise and software skills to streamline time entry, invoicing, and collections processes on the Litify plat...
6 days ago
Senior Enterprise Solution Architect
$102K - $164K *
Join a team that's shaping the future of enterprise solutions by leading innovative design and implementation of scalable architectures. Collaborate with stakeholders, define strategy, and ensure adhe...
Reposted 4 weeks ago
$180K - $235K *
Drive growth by leveraging your consultative sales expertise to engage higher education leaders, aligning their needs with innovative research solutions while managing client relationships and achievi...
2 weeks ago
Senior Director, Strategic Accounts
$140K - $190K *
Empower our sales team by driving strategic growth in key accounts. Leverage your expertise in Enterprise SaaS to navigate complex sales in the Life Sciences sector, fostering partnerships and deliver...
2 weeks ago
Clinical Development Medical Director, Obesity/Cardiovascular
$274K - $371K *
Elevate patient care through innovative clinical strategies in obesity and cardiometabolic development. Collaborate across teams to design and implement late-phase studies, ensuring alignment with glo...
Reposted 1 week ago
Client Onboarding & Operations Associate
$110K - $115K *
Manage the end-to-end onboarding of clients, ensuring exceptional outcomes through strong relationships, effective project management, and data analysis in a fast-paced, high-growth environment...
3 weeks ago
$110K - $130K *
Elevate market presence by driving adoption of innovative cardiac imaging solutions. Collaborate with healthcare professionals to enhance patient care, achieve sales targets, and optimize business str...
3 weeks ago
Stonehaven - Director of Compliance
$150K - $250K *
Shape the future of compliance at our dynamic organization while driving risk oversight, managing external relationships, and guiding teams to meet complex regulatory requirements across insurance ope...
1 month ago
$175K - $400K *
Elevate your career by managing the lifecycle of vendor agreements and contracts. Collaborate across departments to ensure compliance and streamline workflows, safeguarding business interests while mi...
3 weeks ago
$100K - $120K *
Champion financial excellence by optimizing NetSuite for seamless integrations, customizations, and robust forecasting. Drive efficiency and accuracy in financial processes while owning the technical...
Today
$70K - $100K *
Join a team that's committed to financial excellence, ensuring accuracy and compliance in accounting operations. Lead month-end closes, enhance reporting, and drive process improvements while mentorin...
3 days ago
21GRAMS- Senior Delivery Manager
$95K - $100K *
Join our dynamic team as a Technical Delivery Manager, overseeing AI-driven project delivery across diverse digital platforms. Ensure timely, high-quality outputs while leveraging innovative technolog...
6 days ago
Workday Healthcare Financial Implementation Consultant
$140K - $210K *
Partner with us to drive innovative financial solutions in the healthcare sector. Leverage your Workday expertise for impactful implementations, collaborating closely with teams to transform operation...
Reposted 1 week ago
Senior Scientist, Safety Assessment and Investigative Toxicology
$66K - $189K *
Innovate analytical strategies to enhance toxicology assessments, ensuring compliance and data integrity. Collaborate across teams to drive project success and influence decision-making through advanc...
3 days ago
Principal Client Advisor - FinServ (United States)
$150K - $180K *
Empower enterprise clients by managing complex relationships and driving growth. Leverage your expertise to deliver high-impact solutions, ensuring clients achieve measurable outcomes while expanding...
3 weeks ago
Clinical Psychologist (Remote)
$120K - $130K *
Shape the future of mental health care by providing virtual counseling and developing treatment plans for patients with acute conditions. Collaborate with medical professionals while ensuring adherenc...
6 days ago
Lead AI and Data Solution Engineer
$200K - $215K *
Drive the design and deployment of innovative data and AI solutions, leveraging expertise in LLMs, agentic AI, and cloud technologies to enhance business value and ensure compliance with industry stan...
3 weeks ago
Director of Consultant Relations
$110K - $130K *
Unlock potential by cultivating strategic relationships with benefits consultants and brokers. Drive revenue growth through effective partnerships, collaboration with cross-functional teams, and exper...
2 weeks ago
$66K - $169K *
Lead product quality initiatives to ensure compliance and continuous improvement throughout the product lifecycle, partnering with cross-functional teams to enhance manufacturing performance and suppo...
Reposted 6 days ago
What types of $100,000-plus jobs are available in South Dakota?
Depending on current openings, roles may span healthcare, finance, technology, manufacturing, sales, operations, and executive leadership. Requirements and salaries vary by position and employer.
Which South Dakota cities have professional job opportunities?
Sioux Falls and Rapid City are major employment centers, and opportunities may also be available in communities throughout the state.
How can I find high-paying jobs in South Dakota?
Use Ladders to browse vetted professional listings, compare role requirements, and identify openings with salaries of $100,000 or more.
Do South Dakota jobs listed on Ladders all pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Check each listing for its specific compensation details and requirements.